6-Gingerol Ameliorates Adiposity and Inflammation in Adipose Tissue in High Fat Diet-Induced Obese Mice: Association with Regulating of Adipokines

We investigated the effects of 6-gingerol on adiposity and obesity-induced inflammation by focusing on the regulation of adipogenesis and adipokines in white adipose tissue (WAT) of diet-induced obese mice. C57BL/6 mice were fed a high-fat diet (HFD) containing 0.05% 6-gingerol for 8 weeks. 6-Gingerol supplementation significantly reduced body weight, WAT mass, serum triglyceride, leptin and insulin levels, and HOMA-IR in HFD-fed mice. Additionally, the size of adipocytes in epididymal fat pads was reduced in HFD-fed mice by 6-gingerol supplementation. 6-Gingerol reduced the mRNA and protein levels of adipogenesis-related transcription factors, such as SREBP-1, PPAR & gamma;, and C/EBP & alpha; in WAT. Furthermore, 6-gingerol suppressed the expression of lipogenesis-related genes, such as fatty acid synthase and CD36 in WAT. Adiponectin expression was significantly increased, whereas inflammatory adipokines (leptin, resistin, TNF-& alpha;, MCP-1, and PAI-1) and the macrophage marker F4/80 were significantly reduced in the WAT of HFD-fed mice by 6-gingerol supplementation. In conclusion, 6-gingerol effectively contributed to the alleviation of adiposity and inflammation in WAT, which is associated with the regulation of adipokines in diet-induced obese mice.

Automated summary

This study investigated the effects of 6-gingerol on adiposity and obesity-induced inflammation in white adipose tissue of diet-induced obese mice. The results showed that 6-gingerol supplementation significantly reduced body weight, WAT mass, triglyceride, leptin, and insulin levels in HFD-fed mice. It also reduced adipogenesis-related transcription factors and lipogenesis-related genes in WAT. In addition, 6-gingerol increased adiponectin expression and decreased inflammatory adipokines and macrophage marker expression in WAT. In conclusion, 6-gingerol effectively alleviated adiposity and inflammation by regulating adipokines in diet-induced obese mice.