期刊
NUTRIENTS
卷 15, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/nu15204466
关键词
short-chain fatty acid; inflammatory bowel disease; microbiome; gut
The gut microbiome and its product, short-chain fatty acids, play crucial roles in human health and are closely associated with metabolic disorders and inflammation-related diseases. Studying the impact of gut microbiota and its metabolites on inflammatory bowel disease is of great importance.
The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles in a variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation of dietary fiber. Certain microbes in the gut are responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance in gut microbiome diversity can lead to metabolic disorders and inflammation-related diseases. Changes in SCFA levels and associated microbiota were observed in IBD, suggesting an association between SCFAs and disease. The gut microbiota and SCFAs affect reactive oxygen species (ROS) associated with IBD. Gut microbes and SCFAs are closely related to IBD, and it is important to study them further.
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