☆ 4.7 Article

Mechanistic Action of Cell Cycle Arrest and Intrinsic Apoptosis via Inhibiting Akt/mTOR and Activation of p38-MAPK Signaling Pathways in Hep3B Liver Cancer Cells by Prunetrin-A Flavonoid with Therapeutic Potential

NUTRIENTS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Radiology, Nuclear Medicine & Medical Imaging

Life expectancy of patients with hepatocellular carcinoma according to the upfront treatment: A nationwide analysis

Christophe Cassinotto et al.

Summary: The purpose of this study was to update the life expectancy of patients with hepatocellular carcinoma (HCC) based on the initial treatment performed. The findings showed that the five-year survival rates of patients who underwent surgical or interventional radiology procedures were above 50%.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2023)

添加到收藏夹

Article Integrative & Complementary Medicine

Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb. Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis

Ling Jia-yin et al.

Summary: Flavonoids derived from Oldenlandia diffusa can inhibit proliferation and induce apoptosis of human gastric cancer cells by activating the mitochondrial controlled signal transduction pathway.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2023)

添加到收藏夹

Article Medicine, Research & Experimental

Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice

Chunbin Sun et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common lipid metabolism disorder. Autophagy plays a crucial role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active components of Pueraria lobata, have antioxidant and anti-inflammatory effects. This study demonstrates that Pueraria flavonoids can reduce intracellular lipid accumulation and inflammation levels in NAFLD by stimulating autophagy through the PI3K/Akt/mTOR signaling pathway.

BIOMEDICINE & PHARMACOTHERAPY (2023)

添加到收藏夹

Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

添加到收藏夹

Article Food Science & Technology

Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells

Wen Xia et al.

Summary: Polyphenol-rich foods have been shown to be effective in preventing cancer due to their powerful antioxidant properties. This study examined the mechanisms by which wild pink bayberry free phenolic extract (WPBFE) inhibits the proliferation and induces apoptosis of MDA-MB-231 breast cancer cells. The results showed that WPBFE down-regulates expression of PCNA, CDK4, cyclin D1, and up-regulates the expression of p21, leading to cell cycle arrest in the G0/G1 phase. WPBFE also induces apoptosis through the mitochondrial death pathway by up-regulating cleaved caspase-3 and enhancing the ratio of Bax/Bcl-2. Furthermore, WPBFE regulates the p38 MAPK and PI3K/Akt pathways.

FOOD SCIENCE AND HUMAN WELLNESS (2023)

添加到收藏夹

Article Oncology

American Cancer Society's report on the status of cancer disparities in the United States, 2021

Farhad Islami et al.

Summary: This report provides comprehensive data on disparities in cancer occurrence, risk factors, and access to preventive measures and screening in the US. Policy recommendations are made to reduce these inequalities, emphasizing the need for broad implementation of evidence-based interventions to address social inequities and systemic racism.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Glycosidic flavonoids and their potential applications in cancer research: a review

Abuyaseer Abusaliya et al.

Summary: This review highlights the significance of plant-based molecules, particularly glycosidic derivative of flavonoid (GDF), in cancer research. Various flavonoids such as orientin, vitexin, prunetionoside, chrysin, and scutellarein are being investigated for their potential roles in different aspects of cancer research, showing promising results in inhibiting cancer proliferation and inducing apoptosis in cancer cells.

MOLECULAR & CELLULAR TOXICOLOGY (2022)

添加到收藏夹

Review Chemistry, Medicinal

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Asal Jalal Abadi et al.

Summary: Curcumin, isolated from Curcuma longa, has potent tumor-suppressor activity and can decrease the adverse impacts of cisplatin (CP) while enhancing its antitumor activity. Curcumin reduces ROS levels to prevent apoptosis in normal cells, inhibits inflammation, and reduces various toxicities caused by CP. Additionally, curcumin potentiates CP cytotoxicity and suppresses tumor-promoting pathways to prevent drug resistance.

PHYTOTHERAPY RESEARCH (2022)

添加到收藏夹

Review Cell Biology

A review of biologically active flavonoids as inducers of autophagy and apoptosis in neoplastic cells and as cytoprotective agents in non-neoplastic cells

Mark S. D'Arcy

Summary: Phytochemicals, including flavonoids, found in fruits, vegetables, nuts, and legumes have been observed to possess health benefits and can potentially reduce the risk of cancer, heart disease, and neurodegenerative diseases. This review compares the effects and mechanisms of action of several well-characterized and publicized flavonoids, highlighting their potential therapeutic effects. These flavonoids regulate the cell cycle, autophagy, apoptosis, inflammation, and free radicals levels, making them protective of healthy cells but toxic to cancer cells.

CELL BIOLOGY INTERNATIONAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NF-κB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells

Abuyaseer Abusaliya et al.

Summary: In this study, it was found that prunetinoside (PUG), a plant-based compound, possesses anti-inflammatory effects on mouse macrophage cells. PUG decreased the expression of inflammatory mediators and reduced the activation of phosphorylated signaling pathways. By blocking the NF-κB pathway and activating JNK, PUG could be a potential therapeutic compound for inflammatory-related conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Cell Biology

Cell cycle control in cancer

Helen K. Matthews et al.

Summary: This review highlights the importance of cell cycle regulation in preventing genetic errors and cell proliferation, and how disruption of these mechanisms is associated with cancer development. Cancer arises from continuous cell division and evasion of cell cycle control mechanisms.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy

Alakananda Basu

Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.

PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Review Cell Biology

Cell cycle on the crossroad of tumorigenesis and cancer therapy

Jing Liu et al.

Summary: Cell cycle aberrancy is a fundamental mechanism underlying tumorigenesis, and therapies targeting cell cycle machinery components can not only suppress cancer cell division but also reverse cancer metabolism and restore cancer immune surveillance. Recently, proteolysis targeting chimeras (PROTACs) have been used to target oncogenic proteins related to cell cycle progression for more effective tumor suppression.

TRENDS IN CELL BIOLOGY (2022)

添加到收藏夹

Article Food Science & Technology

Natural flavonoid luteolin promotes the differentiation of porcine myoblasts through activation of PI3K/Akt/mTOR signaling

Xin Guan et al.

Summary: This study investigated the effects of four representative flavonoids on porcine myoblasts and found that these flavonoids had relatively low cytotoxicity but showed a weak ability to promote cell proliferation. Luteolin, one of the flavonoids, was found to have a positive effect on migration and differentiation of porcine myoblasts. The activation of the PI3K/Akt/mTOR signaling pathway was identified as the mechanism behind luteolin's effects. This study provided biological evidence for the application of luteolin in cultured meat production.

FOOD BIOSCIENCE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Latifolin, a Natural Flavonoid, Isolated from the Heartwood of Dalbergia odorifera Induces Bioactivities through Apoptosis, Autophagy, and Necroptosis in Human Oral Squamous Cell Carcinoma

Hyung-Mun Yun et al.

Summary: Latif demonstrates significant anticancer effects in oral squamous cell carcinoma by inhibiting cell proliferation, migration, and invasion, inducing apoptotic cell death, targeting multiple signaling pathways, and may serve as a new therapeutic approach for patients with OSCC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Editorial Material Oncology

GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists

S. V. S. Deo et al.

Summary: Cancer is becoming a major global public health challenge, with the burden of cancer increasing globally according to the GLOBOCAN 2020 report which estimates the occurrence of 36 cancers in 185 countries. There are global disparities in cancer incidence and mortality in different geographic regions, and the human development index (HDI) also affects cancer incidence and projected global burden. Surgical oncologists play a crucial role in future global cancer control strategies.

ANNALS OF SURGICAL ONCOLOGY (2022)

添加到收藏夹

Review Oncology

Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?

Cristina Pereira-Wilson

Summary: Activating mutations in KRAS, BRAF, and PI3K play key roles in colorectal cancer development and determine the efficacy of chemotherapeutic agents. Combining natural flavonoids or other phytochemicals with demonstrated effects on these pathways may be a valuable treatment strategy. Clinical trial data is needed to further explore their potential.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multi-Omics Analysis Revealed a Significant Alteration of Critical Metabolic Pathways Due to Sorafenib-Resistance in Hep3B Cell Lines

Kholoud Y. Abushawish et al.

Summary: This study investigated the proteomic and metabolomics alterations associated with sorafenib resistance in hepatocellular carcinoma cells. The findings identified potential biomarkers for sorafenib-resistant HCC and provided insights into their role in chemotherapeutic drug resistance, cancer progression, and aggressiveness.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

Juhaer Anjum et al.

Summary: Abnormalities in the MAPK signaling pathway contribute to carcinogenesis, while polyphenols can modulate this pathway to inhibit cancer cell growth and metastasis.

PHARMACOLOGICAL RESEARCH (2022)

添加到收藏夹

Article Cell Biology

Apigetrin Promotes TNFα-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NF-κB Pathway in Hep3B Liver Cancer Cells

Pritam Bhagwan Bhosale et al.

Summary: The study showed that apigetrin inhibited the growth and proliferation of Hep3B liver cancer cells and induced apoptosis and necroptosis. The underlying mechanisms involved cell cycle arrest, increased reactive oxygen species levels, and regulation of related proteins. These findings suggest the potential therapeutic effect of apigetrin in liver cancer treatment.

CELLS (2022)

添加到收藏夹

Review Pathology

LncRNAs and miRNAs participate in determination of sensitivity of cancer cells to cisplatin

Mohammad Taheri et al.

Summary: Cisplatin is widely used in chemotherapy for various cancers, but chemoresistance can impede its effectiveness. Recent research has highlighted the role of lncRNAs and miRNAs in the development of resistance to cisplatin, affecting overall survival of cancer patients.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

A new flavonoid derivative exerts antitumor effects against androgen-sensitive to cabazitaxel-resistant prostate cancer cells

Renato Naito et al.

Summary: The derivative 16MS7F1924 showed significant antitumor effects on prostate cancer cells by inhibiting AR activity, reducing PSA expression, inducing mitotic catastrophe and apoptosis, mediated through the Akt pathway. In vivo studies demonstrated that 16MS7F1924 effectively inhibited tumor growth in both androgen-sensitive and cabazitaxel-resistant PCa cells, suggesting its potential as a novel therapeutic agent for hormone- and chemoresistant PCas.

PROSTATE (2021)

添加到收藏夹

Article Oncology

A Network Pharmacological Approach to Reveal the Pharmacological Targets and Its Associated Biological Mechanisms of Prunetin-5-O-Glucoside against Gastric Cancer

Preethi Vetrivel et al.

Summary: This study utilized a network pharmacology approach to identify that the core targets of PG against gastric cancer are HSP90AA1, CDK2, and MMP1. Functional enrichment and pathway analysis revealed significant biological mechanisms associated with these targets.

CANCERS (2021)

添加到收藏夹

Article Chemistry, Applied

Cuminum cyminum fruits as source of luteolin-7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines

Saied Goodarzi et al.

NATURAL PRODUCT RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

Alessandra Scagliarini et al.

CELLS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Compound Prunetin Induces Cell Death in Gastric Cancer Cell with Potent Anti-Proliferative Properties: In Vitro Assay, Molecular Docking, Dynamics, and ADMET Studies

Preethi Vetrivel et al.

BIOMOLECULES (2020)

添加到收藏夹

Review Oncology

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

Cornelia Braicu et al.

CANCERS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs

Robert Roskoski

PHARMACOLOGICAL RESEARCH (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics

Rehmat Jan et al.

ADVANCED PHARMACEUTICAL BULLETIN (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

JOURNAL OF HEPATOLOGY (2018)

添加到收藏夹

Article Chemistry, Applied

A phenylacetaldehyde-flavonoid adduct, 8-C-(E-phenylethenyl)-norartocarpetin, exhibits intrinsic apoptosis and MAPK pathways-related anticancer potential on HepG2, SMMC-7721 and QGY-7703

Zong-Ping Zheng et al.

FOOD CHEMISTRY (2016)

添加到收藏夹

Article Oncology

Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA)

J. L. Petrick et al.

BRITISH JOURNAL OF CANCER (2015)

添加到收藏夹

Article Pharmacology & Pharmacy

LW-214, a newly synthesized flavonoid, induces intrinsic apoptosis pathway by down-regulating Trx-1 in MCF-7 human breast cells

Di Pan et al.

BIOCHEMICAL PHARMACOLOGY (2014)

添加到收藏夹

Article Food Science & Technology

Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells

Ning Kang et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

添加到收藏夹

Review Oncology

Targeting PI3K/Akt/mTOR signaling in cancer

Camillo Porta et al.

FRONTIERS IN ONCOLOGY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

Chu-Chiao Wu et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Libero Santarpia et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

添加到收藏夹

Article Oncology

Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

Terence M. Williams et al.

MOLECULAR CANCER THERAPEUTICS (2012)

添加到收藏夹

Article Toxicology

The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells

Jung-Hee Kim et al.

TOXICOLOGY IN VITRO (2012)

添加到收藏夹

Review Cell Biology

MAPK signaling in inflammation-associated cancer development

Pengyu Huang et al.

PROTEIN & CELL (2010)

添加到收藏夹

Review Oncology

Cell cycle, CDKs and cancer: a changing paradigm

Marcos Malumbres et al.

NATURE REVIEWS CANCER (2009)

添加到收藏夹

Review Cell Biology

Cytochrome c:: functions beyond respiration

Yong-Ling P. Ow et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

添加到收藏夹

Review Oncology

Targeting apoptosis pathways in cancer therapy

IM Ghobrial et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2005)

添加到收藏夹

Review Oncology

PI3K/Akt/mTOR pathway as a target for cancer therapy

D Morgensztern et al.

ANTI-CANCER DRUGS (2005)

添加到收藏夹

Review Oncology

PI3K/Akt signalling pathway and cancer

JAF Vara et al.

CANCER TREATMENT REVIEWS (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cisplatin: mode of cytotoxic action and molecular basis of resistance

ZH Siddik

ONCOGENE (2003)

添加到收藏夹

Review Oncology

Cell cycle and apoptosis

B Pucci et al.

NEOPLASIA (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.