4.7 Review

The Role of Endocrine Disrupting Chemicals in Gestation and Pregnancy Outcomes

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Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case-control study in Guangxi, China

Peng Tang et al.

Summary: This study investigated the associations between endocrine-disrupting chemicals and gestational diabetes mellitus (GDM). The results showed that maternal serum levels of BPA, BPB, BPF, BPS, and TBBPA were associated with the risk of GDM. Specifically, BPS showed a positive association with GDM risk, while BPA and TBBPA showed a negative association. Furthermore, exposure to a mixture of the five bisphenols was negatively associated with the risk of GDM.

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Exposure to endocrine-disrupting chemicals and risk of gestational hypertension and preeclampsia: A systematic review and meta-analysis*

Amol Hirke et al.

Summary: Prenatal exposure to certain endocrine-disrupting chemicals, such as perfluorooctanoic acid (PFOA), perfluoro octane sulfonic acid (PFOS), perfluononanoic acid (PFNA), and mono-ethyl phthalate (MEP), is associated with an increased risk of gestational hypertension (GH) and preeclampsia (PE). However, exposure to bisphenol A during pregnancy does not show a significant association with the risk of PE. More research is needed to confirm these findings, as the evidence for most of these associations is limited.

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Association Between Phthalate Exposure in Pregnancy and Gestational Diabetes: A Chinese Cross-Sectional Study

Qiu-Xia Liang et al.

Summary: The present study investigates the association between phthalate exposure and the risk of gestational diabetes mellitus (GDM). The results show that patients in the GDM group have higher concentrations of mono(2-ethylhexyl) phthalate (MEHP) and methylerythritol cyclophosphane. Significant MEHP-GDM associations were observed and the dose-response relationships differ among different age and gestational week groups.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Review Endocrinology & Metabolism

Weight gain during pregnancy: A narrative review on the recent evidences

Maria Grazia Dalfra' et al.

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Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis

Dandan Yan et al.

Summary: This study conducted a comprehensive systematic review and meta-analysis to investigate the relationship between exposure to certain endocrine-disrupting chemicals (EDCs) and the risk of gestational diabetes mellitus (GDM). The results showed that exposure to PCBs, PBDEs, PAEs, and PFAS increased the risk of GDM. Further research is needed to confirm this relationship and explore the underlying mechanisms.

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Exposure to phthalates in early pregnancy and the risk of fetal growth restriction: a nested case-control study in a Zhuang Chinese population

Xiaojing Guo et al.

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F. O. Awobajo et al.

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Maternal diet quality moderates associations between parabens and birth outcomes

Diana C. Pacyga et al.

Summary: The study found that maternal exposure to parabens may impact birth size, with this impact being influenced by maternal diet quality and infant gender. In cases of poorer maternal diets, the association between parabens and birth size in female infants was more prominent.

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Sex-specific associations between maternal exposure to parabens, phenols and phthalates during pregnancy and birth size outcomes in offspring

Cecilie S. Uldbjerg et al.

Summary: This study found that prenatal exposure to bisphenol A (BPA) and methyl paraben (MeP) may have negative effects on birth size, with a possible sex difference. These findings need to be replicated in larger studies due to the small sample size.

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Does Older Age Modify Associations between Endocrine Disrupting Chemicals and Fecundability?

Anna Z. Pollack et al.

Summary: This study investigated the relationship between endocrine disrupting chemicals (EDCs) concentrations and time-to-pregnancy (TTP), finding that females aged >=35 years could lead to longer TTP. However, there was no evidence of effect modification by couples' age on associations between TTP and urinary phthalate or BPA metabolite concentrations.

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Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth A Pooled Study of 16 US Cohorts

Barrett M. Welch et al.

Summary: A large study conducted in the US found that phthalate exposure during pregnancy may increase the odds of preterm birth. Reducing the concentration of phthalate metabolites could potentially prevent preterm births.

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Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice

XueXia Liu et al.

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Association of phthalate exposure with thyroid function during pregnancy

Arash Derakhshan et al.

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Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts

Elvis Ticiani et al.

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Prenatal exposure to phthalates and maternal metabolic outcomes in a high-risk pregnant Latina population

Helen Zukin et al.

Summary: In a study of 415 pregnant Latina women, prenatal phthalate levels were not associated with hyperglycemia, impaired glucose tolerance, or gestational diabetes. However, there was an increased risk of excessive gestational weight gain.

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First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hypertensive Diseases of Pregnancy

Sabrina M. Bedell et al.

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Urinary Concentrations of Bisphenol Mixtures during Pregnancy and Birth Outcomes: The MAKE Study

Seyoung Kim et al.

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Prenatal exposure to bisphenols affects pregnancy outcomes and offspring development in rats

Amrita Kaimal et al.

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Wei-Hsiang Chang et al.

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David Lopez-Rodriguez et al.

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Exploring associations between prenatal exposure to multiple endocrine disruptors and birth weight with exposure continuum mapping

John L. Pearce et al.

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Association of maternal exposure to bisphenol A with her β-hCG level and neonatal anthropometric measures

Mohammad Mehdi Amin et al.

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Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

Kristen G. Harnett et al.

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