期刊
NUTRIENTS
卷 15, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/nu15194117
关键词
L-glutamine; head and neck cancer; chemoradiotherapy; overall survival; progression-free survival; glutathione; overall response rate; oral glutamine supplementation; mucositis; reactive oxygen species
L-glutamine does not influence the survival of patients with locally advanced head and neck cancer receiving chemoradiotherapy.
We previously reported that L-glutamine reduces the severity of mucositis caused by chemoradiotherapy in patients with head and neck cancer. However, the impact of glutamine on the anti-tumor effect of chemoradiotherapy remains controversial. This study, which included 40 patients, investigated whether L-glutamine influences survival. Radiation therapy (total: 66 or 70 Gy), cisplatin, and docetaxel were co-administered for a period of 6 weeks. Patients were randomly assigned to receive either glutamine (glutamine group, n = 20) or placebo (placebo group, n = 20) during the entire course of chemoradiotherapy. We compared the overall survival and progression-free survival rates between the two groups. At 5-year follow-up, 16 (80%) and 13 (72%) patients in the glutamine and placebo groups, respectively, survived (with no significant difference in overall survival [glutamine group: 55.2 +/- 12.7 months vs. placebo group: 48.3 +/- 21.3 months]). A total of 14 (70%) and 12 (67%) patients in the glutamine and placebo groups, respectively, did not experience disease progression (with no significant difference in progression-free survival [glutamine group: 46.7 +/- 19.5 months vs. placebo group: 43.6 +/- 25.2 months]). These findings indicate that L-glutamine does not influence the survival of patients with locally advanced head and neck cancer receiving chemoradiotherapy.
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