4.7 Article

PEMT rs7946 Polymorphism and Sex Modify the Effect of Adequate Dietary Choline Intake on the Risk of Hepatic Steatosis in Older Patients with Metabolic Disorders

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Gastroenterology & Hepatology

NAFLD-related hepatocellular carcinoma: The growing challenge

Pir Ahmad Shah et al.

Summary: Hepatocellular carcinoma (HCC) related to non-alcoholic fatty liver disease (NAFLD) is a common cause of cancer-related mortality and morbidity worldwide. The burden of NAFLD-related HCC is exponentially increasing due to the obesity pandemic. Cirrhosis is a major risk factor for NAFLD-related HCC, but it is increasingly recognized that patients without cirrhosis can also develop NAFLD-related HCC, posing a significant challenge for cancer surveillance. Therefore, developing optimal risk stratification scores and models to identify high-risk populations for surveillance is of paramount importance.

HEPATOLOGY (2023)

Review Biochemistry & Molecular Biology

Nutritional Genomics in Nonalcoholic Fatty Liver Disease

Carolina Vasconcellos et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic condition in which fat accumulates abnormally in the liver due to genetic and environmental factors. It is associated with obesity, type 2 diabetes, and dyslipidemia. Both genetic factors (such as epigenetic mechanisms and polymorphisms in genes like PNPLA3, TM6SF2, PEMT, and CHDH) and environmental factors (such as physical inactivity and imbalanced diet) contribute to the development of NAFLD.

BIOMEDICINES (2023)

Review Biochemistry & Molecular Biology

Genetic Polymorphisms and Diversity in Nonalcoholic Fatty Liver Disease (NAFLD): A Mini Review

Siti Aishah Sulaiman et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with a wide spectrum of liver conditions. Genetic polymorphisms play a role in NAFLD's development and progression, but there are differences in findings between populations. Understanding the genetic contribution of NAFLD is important for tailored diagnosis and management.

BIOMEDICINES (2023)

Review Geriatrics & Gerontology

Phosphatidylethanolamine N-methyltransferase: from Functions to Diseases

Jiayu Li et al.

Summary: Phosphatidyl Ethanolamine Methyltransferase (PEMT), located on the endoplasmic reticulum and mitochondria associated membrane, regulates phospholipid metabolism. Dysregulation of PEMT is associated with the development of diseases such as fatty liver and cardiovascular diseases.

AGING AND DISEASE (2023)

Article Nutrition & Dietetics

Optimal Dietary Intake Composition of Choline and Betaine Is Associated with Minimized Visceral Obesity-Related Hepatic Steatosis in a Case-Control Study

Ting-Yu Chang et al.

Summary: This case-control study found that intake of choline and betaine is associated with the development of hepatic steatosis, with low intake being linked to increased odds and high intake associated with a significant reduction in risk.

NUTRIENTS (2022)

Article Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

Kylynda C. Bauer et al.

Summary: Nonalcoholic fatty liver disease is a common chronic condition associated with obesity and metabolic syndrome, but it is also influenced by undernutrition and dysbiotic gut microbiome. The relationship between undernutrition and NAFLD is not well studied. This review discusses the features of fatty liver in undernutrition conditions and the gut microbiota-liver axis, highlighting key pathways in NAFLD progression under both overnutrition and undernutrition. The challenges and collaborative possibilities in emerging multiomic research for the pathology and treatment of undernourished NAFLD are also identified.

GASTROENTEROLOGY (2022)

Review Gastroenterology & Hepatology

Changing clinical management of NAFLD in Asia

Takuma Nakatsuka et al.

Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is rapidly increasing and varies widely across regions due to lifestyle and environmental factors. The dual etiology of fatty liver, along with underrepresentation in clinical trials, makes managing NAFLD complex and challenging for Asian patients.

LIVER INTERNATIONAL (2022)

Review Gastroenterology & Hepatology

Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world

Linda Henry et al.

Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally, especially in Asia, MENA, and Latin America. High prevalence rates are observed among obese and metabolic syndrome patients, while awareness of the disease remains low among patients and healthcare providers.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

Review Biochemistry & Molecular Biology

Trimethylamine N-Oxide Levels in Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Panagiotis Theofilis et al.

Summary: Patients with Non-alcoholic fatty liver disease have increased levels of circulating trimethylamine N-oxide (TMAO), suggesting its important role in gut-liver interaction.

METABOLITES (2022)

Article Biochemistry & Molecular Biology

Hepatic PEMT Expression Decreases with Increasing NAFLD Severity

Ignazio S. Piras et al.

Summary: Choline deficiency is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD) and more advanced NAFLD-related hepatic fibrosis. Reduced expression of the hepatic phosphatidylethanolamine N-methyltransferase (PEMT) enzyme causes steatosis, inflammation, and fibrosis in mice, and common PEMT variants in humans impair phosphatidylcholine synthesis and increase NAFLD risk. This study investigated the expression of hepatic PEMT and its genetic variants in a large cohort of NAFLD patients and found that reduced PEMT expression is linked to inflammation and fibrosis in NAFLD patients, with severity of fibrosis being a factor. Additionally, reduced PEMT expression was observed in postmenopausal women with NAFLD, and certain genetic variants were suggestive of an association with hepatic fibrosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Pharmacology & Pharmacy

Genetic risk scores and personalization of care in fatty liver disease

Cristiana Bianco et al.

Summary: Nonalcoholic fatty liver disease is the leading cause of chronic liver disease, with genetic predisposition, lifestyle, and metabolic comorbidities contributing to its development and progression. Polygenic risk scores (PRS) calculated from an individual's trait-associated alleles can help assess genetic risk and potentially aid in early disease detection, risk stratification, targeted prevention programs, hepatocellular carcinoma surveillance, and precision medicine approaches.

CURRENT OPINION IN PHARMACOLOGY (2021)

Editorial Material Biophysics

Cubic splines to model relationships between continuous variables and outcomes: a guide for clinicians

J. Gauthier et al.

BONE MARROW TRANSPLANTATION (2020)

Article Biochemistry & Molecular Biology

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance

Sereana Wan et al.

FASEB JOURNAL (2019)

Article Medicine, General & Internal

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

P. Dongiovanni et al.

JOURNAL OF INTERNAL MEDICINE (2018)

Review Nutrition & Dietetics

Dietary Choline Intake: Current State of Knowledge Across the Life Cycle

Alejandra M. Wiedeman et al.

NUTRIENTS (2018)

Article Endocrinology & Metabolism

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Elena Buzzetti et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Article Nutrition & Dietetics

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease

Anthony L. Guerrerio et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2012)

Review Biochemistry & Molecular Biology

Phosphatidylcholine biosynthesis and lipoprotein metabolism

Laura K. Cole et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Review Gastroenterology & Hepatology

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

Karen D. Corbin et al.

CURRENT OPINION IN GASTROENTEROLOGY (2012)

Review Biochemistry & Molecular Biology

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation

Olivia S. Anderson et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2012)

Article Medical Laboratory Technology

The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism

Michael Lever et al.

CLINICAL BIOCHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Phosphatidylcholine and choline homeostasis

Zhaoyu Li et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Common genetic polymorphisms affect the human requirement for the nutrient choline

Kerry-Ann da Costa et al.

FASEB JOURNAL (2006)

Article Biochemistry & Molecular Biology

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)

JN Song et al.

FASEB JOURNAL (2005)

Review Gastroenterology & Hepatology

Non-alcoholic steatohepatitis in the Asia-Pacific region: Future shock?

S Chitturi et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2004)

Article Gastroenterology & Hepatology

Non-alcoholic steatohepatitis: What is it, and why is it important in the Asia-Pacific region?

GC Farrell

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2003)

Article Nutrition & Dietetics

Choline deficiency-induced liver damage is reversible in Pemt(-/-) mice

KA Waite et al.

JOURNAL OF NUTRITION (2002)

Article Radiology, Nuclear Medicine & Medical Imaging

Quantitative estimation of attenuation in ultrasound video images - Correlation with histology in diffuse liver disease

M Graif et al.

INVESTIGATIVE RADIOLOGY (2000)