4.7 Review

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

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Genetically engineered nano-melittin vesicles for multimodal synergetic cancer therapy

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Summary: A novel genetically engineered vesicular antibody-melittin (VAM) drug delivery platform was developed for targeted cancer combination therapy. The VAM could release nanomelittin at tumor sites in a controlled manner, reducing off-target toxicity and allowing co-delivery of small-molecule drugs or nanoparticles. This strategy achieved enhanced therapeutic effects through the synergistic action of nanomelittin and anticancer agents.

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Yan Luo et al.

Summary: The primary goal of this study was to investigate the effect of melittin on colorectal cancer (CRC). The viability of cancer cells was inhibited and apoptosis was induced in CRC cell lines by melittin treatment, which was accompanied by endoplasmic reticulum stress and calcium imbalance. In vivo experiments using a xenograft mouse model confirmed the inhibitory effect of melittin on tumour growth.

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Summary: Melittin, a major peptide constituent of bee venom, has potential anticancer effects against breast cancer cells and can enhance the efficacy of radiation therapy by inducing apoptosis.

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Therapeutic Effect of Melittin-dKLA Targeting Tumor-Associated Macrophages in Melanoma

Ik-Hwan Han et al.

Summary: This study found that melittin-dKLA inhibits the growth of melanoma by inducing apoptosis of M2-like macrophages. In in vitro and in vivo studies, melittin-dKLA effectively reduced the proliferation and migration of M2 macrophages, resulting in a decrease in melanoma tumor growth.

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Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer

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The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer

Pelin Erkoc et al.

Summary: The venom of honeybees, specifically melittin peptides, has shown potential therapeutic effects on inflammation and cancer. This study explores the pharmacological activities of known and newly discovered melittin variants from honeybees and older solitary bees in the context of cancer and inflammation. The findings suggest that some ancestral variants from solitary bees have promising therapeutic potential in modulating inflammatory processes and inhibiting cancer cell viability/proliferation, including aggressive breast cancers.

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Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

Yonghui Lv et al.

Summary: This study proposes a therapeutic solution based on substituting Trp19 with a noncanonical fluorescent amino acid, which improves the selectivity and reduces the hemolytic toxicity of melittin.

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Bee venom induces anti-tumor effects in HT-29 colon cancer cells through regulation of cell proliferation and apoptosis

Hossein Saghi et al.

Summary: This study evaluates the anti-tumor effects of bee venom (BV) on colorectal cancer-derived HT-29 cells. The results demonstrate that BV reduces cell viability, induces apoptosis and necrosis, and has anti-inflammatory properties. This study suggests that BV has the potential to be developed as a natural anti-cancer agent.

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Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines

Danijela D. Nikodijevic et al.

Summary: This study suggests that bee venom and its dominant compound melittin have anticancer properties against colorectal carcinoma cells by inducing proapoptotic activity and suppressing genes involved in biotransformation process. They also show selectivity against cancer cells compared to normal cells, indicating potential for developing resistance in colorectal cancer cells.

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In vivo and invitro experimentation for scientific validation of the traditional use of Chromolaena odorata (L.) against envenomation of honey bee sting

Tania S. Das et al.

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Stable Loading and Delivery of Melittin with Lipid-Coated Polymeric Nanoparticles for Effective Tumor Therapy with Negligible Systemic Toxicity

Ran Ye et al.

Summary: A biocompatible and stable melittin-loaded lipid-coated polymeric nanoparticle formulation was designed to address the obstacles of melittin in clinical applications, showing high stability and antitumor activity.

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Development of D-melittin polymeric nanoparticles for anti-cancer treatment

Shixian Lv et al.

Summary: Melittin, the primary peptide component in bee venom, has anti-tumor activity but its practical application is hindered by hemolytic activity and instability. Use of D-amino acids in place of L-amino acids reduces immunogenicity of melittin, allowing for safer delivery and maintaining cytolytic potential. D-melittin micelles show cytotoxicity in a pH-dependent manner, inducing immunogenic cell death and demonstrating potential for cancer immunotherapy. The study presents a new strategy for systemic delivery of cytotoxic peptides in cancer treatment.

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Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells

Ghada H. Mansour et al.

Summary: The study found that Bee Venom and its active component, Melittin, when combined with Sorafenib, have a synergistic anticancer effect on HepG2 cells, potentially representing a new enhancing strategy for HCC treatment.

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Melittin sensitizes skin squamous carcinoma cells to 5-fluorouracil by affecting cell proliferation and survival

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Summary: The combination of 5-fluorouracil and melittin was found to have a stronger cytotoxic effect on skin squamous cell carcinoma cells, potentially inducing apoptosis by affecting cell membrane, DNA, mitochondria, and other structures. This combination therapy may optimize cytotoxic effects at lower concentrations, representing an innovative strategy for SCC treatment.

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Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates

Shaimaa M. Badr-Eldin et al.

Summary: Fluvastatin and melittin have shown potential anticancer activity, but also come with adverse effects. This study found an optimized formulation that significantly improved the cytotoxic potential of the drugs, potentially representing a novel approach for developing more effective anticancer drugs against ovarian cancer.

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Melittin, a honeybee venom derived peptide for the treatment of chemotherapy-induced peripheral neuropathy

Tenzin Tender et al.

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The Cytotoxic Effect of Apis mellifera Venom with a Synergistic Potential of Its Two Main Components-Melittin and PLA2-On Colon Cancer HCT116 Cell Lines

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Melittin inhibits the expression of key genes involved in tumor microenvironment formation by suppressing HIF-1α signaling in breast cancer cells

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Hyaluronic Acid Coating Reduces the Leakage of Melittin Encapsulated in Liposomes and Increases Targeted Delivery to Melanoma Cells

Yanyan Li et al.

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Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

Farnaz Dabbagh Moghaddam et al.

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Melittin suppresses epithelial-mesenchymal transition and metastasis in human gastric cancer AGS cells via regulating Wnt/BMP associated pathway

Jye-Yu Huang et al.

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TERT promoter regulating melittin expression induces apoptosis and G0/G1 cell cycle arrest in esophageal carcinoma cells

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