☆ 4.7 Review

Clinical Studies on the Supplementation of Manufactured Human Milk Oligosaccharides: A Systematic Review

NUTRIENTS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Food Science & Technology

Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

Carolina de Weerth et al.

Summary: Human milk is a complex liquid food that is customized to meet the needs of infants. The non-nutrient bioactives in milk have an impact on child cognitive and behavioral development, a process known as 'Lactocrine Programming'. This review discusses the links between human milk composition and child cognitive and behavioral development, and provides recommendations for future studies.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Specific Human Milk Oligosaccharides Differentially Promote Th1 and Regulatory Responses in a CpG-Activated Epithelial/Immune Cell Coculture

Marit Zuurveld et al.

Summary: Proper early-life immune development is crucial for a healthy immune system. Human milk oligosaccharides (HMOS) have immunomodulatory properties that are essential for neonatal immune maturation. In this study, five HMOS present in human milk were studied for their effects on the immune system. The results showed that 2'FL and 3FL had the most pronounced immunomodulatory effects, enhancing the secretion of key immune mediators.

BIOMOLECULES (2023)

添加到收藏夹

Article Nutrition & Dietetics

Evidence for human milk as a biological system and recommendations for study design-a report from Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN) Working Group 4

Sharon M. Donovan et al.

Summary: Human milk is rich in essential nutrients and bioactive components that have important health benefits for infants. Understanding the complexity of the human milk matrix and its interactions is crucial for designing and interpreting studies. New tools and technologies are needed to explore the biological system of human milk and its functional implications.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2023)

添加到收藏夹

Article Microbiology

2022 Fleming Prize Lecture: diet-microbe-host interaction in early life

Christopher J. Stewart

Summary: The past decade has seen a significant increase in research on the human microbiome and its correlation with disease risk. The use of sequencing technology has replaced gel-based fingerprinting methods for studying microbial ecology, while traditional microbiological culture is experiencing a revival. This review focuses on the bacterial community in early life, particularly in term infants and prematurely born infants, and highlights the impact of human milk oligo-saccharides (HMOs) on the infant microbiome and the growth of Bifidobacterium spp. These findings have important implications for preterm infants at risk of necrotizing enterocolitis, a leading cause of mortality and long-term morbidity in this population.

JOURNAL OF MEDICAL MICROBIOLOGY (2023)

添加到收藏夹

Article Nutrition & Dietetics

Infants Fed Breastmilk or 2'-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids

David R. Hill et al.

Summary: Human milk is the best source of nutrition for infants, as it provides growth factors, commensal microbes, and prebiotic compounds to the developing gastrointestinal tract. This study investigated the effects of adding human milk oligosaccharides (HMOs) to infant formula on serum metabolite levels. The results showed that fortifying formula with the HMO 2'-fucosyllactose (2'-FL) significantly increased the production of secondary bile acids, indicating that HMO supplementation may have important implications for gut microbial metabolism.

NUTRIENTS (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Functional effects of human milk oligosaccharides (HMOs)

Meltem Dinleyici et al.

Summary: Human milk oligosaccharides (HMOs) are important components in human milk, varying greatly between mothers. HMOs improve gut health, protect against infection, and promote cognitive development. Supplementing formula with HMOs is safe and beneficial for microbiota composition and infection prevention, but the clinical benefits compared to non-human oligosaccharides are not known. More research is needed to understand the factors influencing HMO composition and their functions.

GUT MICROBES (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Translating neonatal microbiome science into commercial innovation: metabolism of human milk oligosaccharides as a basis for probiotic efficacy in breast-fed infants

David A. Mills et al.

Summary: For more than 100 years, doctors have observed the presence of bifidobacteria in the feces of breast-fed infants, which has been linked to their health. Recent advancements in genomics and glycomics have helped explain this enrichment and allowed for the targeted use of probiotics to restore bifidobacterial functions in at-risk infants. This review highlights two decades of research that has paved the way for the use of bifidobacteria in the intestines of at-risk newborns, and proposes a model for measuring probiotic efficacy in improving infant health based on metabolic outcomes.

GUT MICROBES (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Henrik M. Roager et al.

Summary: The development of the infant gut microbiome is crucial for the microbiome ecology, function, and host health. Technological advancements now allow for better profiling of metabolites in the infant gut, providing insights into the roles of microbial-derived metabolites in shaping the microbiome community and influencing host-microbial interactions during early life. This review summarizes the current knowledge on the development of the infant gut microbiota and metabolism within the first year of life, emphasizing the importance of microbial metabolites in enhancing our understanding of early life interactions.

GUT MICROBES (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow's Milk Protein Allergy

Claire L. K. Boulange et al.

Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children. A study was conducted on non-breastfed infants with CMPA to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome. The supplementation of human milk oligosaccharides (HMO) enriched bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition towards an adult-like pattern. HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Immunology

Human milk oligosaccharides: potential therapeutic aids for allergic diseases

Isabel Tarrant et al.

Summary: Childhood allergy, especially asthma, eczema, and food allergies, is a significant global health concern, and there is a need for new interventions. Recent research suggests that human milk oligosaccharides (HMOs) found in breastmilk have allergy-protective properties, offering potential therapeutic benefits. This review evaluates the role of HMOs in allergy prevention, discusses underlying immunological mechanisms, and highlights the importance of breastfeeding encouragement and HMO-supplemented formula milk for high allergy-risk infants.

TRENDS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Nutrition & Dietetics

Infant Formula Supplemented with Five Human Milk Oligosaccharides Shifts the Fecal Microbiome of Formula-Fed Infants Closer to That of Breastfed Infants

Andrea Q. Holst et al.

Summary: Breastmilk is the optimal source of infant nutrition, and human milk oligosaccharides (HMOs) play a significant role in the health benefits of breastmilk. This study investigated the effects of supplementing infant formula with a mix of five different HMOs, and found that the formula influenced the fecal microbiome composition and function, leading to an increase in bifidobacteria and shared features with breastfed infants.

NUTRIENTS (2023)

添加到收藏夹

Review Nutrition & Dietetics

Biology of human milk oligosaccharides: From basic science to clinical evidence

Norbert Sprenger et al.

Summary: Human milk oligosaccharides (HMOs) are important components of breast milk that have significant impact on the health and nutrition of infants. The research on HMOs has flourished in the past decade, thanks to advancements in biotechnology that allow for large-scale production of genuine HMOs. The clinical relevance of specific HMOs has been supported by clinical intervention trials in formula-fed infants, as well as clinical observations and animal models.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Safety and efficacy of a probiotic-containing infant formula supplemented with 2'-fucosyllactose: a double-blind randomized controlled trial

Philippe Alliet et al.

Summary: This study demonstrates that an infant formula containing 2'FL and L. reuteri supports age-appropriate growth, is well-tolerated, and may help regulate gut microbiota composition.

NUTRITION JOURNAL (2022)

添加到收藏夹

Article Nutrition & Dietetics

Effects of an Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety and Infection Risk in Infants with Cow's Milk Protein Allergy: A Randomized, Multi-Center Trial

Yvan Vandenplas et al.

Summary: This clinical trial demonstrates that an extensively hydrolyzed formula supplemented with HMO supports normal growth in infants with CMPA and provides a protective effect against respiratory and ear infections.

NUTRIENTS (2022)

添加到收藏夹

Article Microbiology

Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics

Julie E. Button et al.

Summary: By pairing infant gut microbe B. infantis with human milk oligosaccharides (HMO) in a synbiotic approach, we found that B. infantis can engraft into the healthy adult gut and significantly influence the metabolites. This synbiotic method also shows promising results in complex microbial environments.

CELL HOST & MICROBE (2022)

添加到收藏夹

Article Medicine, Legal

Randomized, triple-blind, placebo-controlled study to evaluate the safety of 6'-Sialyllactose in healthy adults

Ji Hyun Kim et al.

Summary: Sialyllactoses (SL) are abundant components in human milk and have been extensively studied for their biological effects in humans. SL can be synthesized economically using enzyme synthesis. The safety and appropriate intake dose of 6'-SL sodium salt as a novel food has been published by the European Food Safety Authority, but the appropriate dose for specific medical purposes still needs to be determined on a case-by-case basis. Furthermore, there is a lack of data on the toxicity of 6'-SL in human intervention. This study aims to determine the safety of 6'-SL use in humans through a 12-week clinical trial, and the results support the safety of 6'-SL for human use.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2022)

添加到收藏夹

Article Nutrition & Dietetics

Human Milk Oligosaccharides Are Present in Amniotic Fluid and Show Specific Patterns Dependent on Gestational Age

Evelyn Jantscher-Krenn et al.

Summary: This study found that human milk oligosaccharides (HMOs) are present in amniotic fluid throughout pregnancy, and their composition varies with gestational age. The early presence of HMOs in amniotic fluid suggests their potential role in fetal tissue development.

NUTRIENTS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow's Milk Protein Allergy

Michael S. Gold et al.

Summary: This study aimed to evaluate whether an amino acid-based formula supplemented with two human milk oligosaccharides can support normal growth and tolerance in infants with cow's milk protein allergy. The results showed that the formula improved the weight and growth of the infants and was well tolerated. Additionally, the formula partially corrected the gut microbial dysbiosis in these infants.

NUTRIENTS (2022)

添加到收藏夹

Article Pediatrics

Use of a Liquid Supplement Containing 2 Human Milk Oligosaccharides: The First Double-Blind, Randomized, Controlled Trial in Pre-term Infants

Jean-Michel Hascoet et al.

Summary: There is increasing evidence supporting the benefits of human milk oligosaccharides (HMOs) in reducing the risk of illnesses and improving immune function in newborn infants. This study aimed to evaluate the effects of HMO supplementation on feeding tolerance, growth, and safety in pre-term infants. The results showed that HMO supplementation is safe and well-tolerated in pre-term infants and supports early postnatal growth.

FRONTIERS IN PEDIATRICS (2022)

添加到收藏夹

Article Pediatrics

Summary of the joint National Institutes of Health and the Food and Drug Administration workshop titled “exploring the science surrounding the safe use of bioactive ingredients in infant formula: Considerations for an assessment framework”

Sharon M. Donovan et al.

JOURNAL OF PEDIATRICS (2022)

添加到收藏夹

Review Microbiology

The Potential Role of Human Milk Oligosaccharides in Irritable Bowel Syndrome

Patricia Sanz Morales et al.

Summary: Irritable Bowel Syndrome is a common gastrointestinal disorder, and human milk oligosaccharides show promise as a potential therapeutic option for improving symptoms by altering the gut microbiota.

MICROORGANISMS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Growth and Gastrointestinal Tolerance in Healthy Term Infants Fed Milk-Based Infant Formula Supplemented with Five Human Milk Oligosaccharides (HMOs): A Randomized Multicenter Trial

John Lasekan et al.

Summary: In healthy term infants, a formula containing five HMOs supports normal growth, gastrointestinal tolerance, and safe use, similar to human milk.

NUTRIENTS (2022)

添加到收藏夹

Article Nutrition & Dietetics

Infant Formula With a Specific Blend of Five Human Milk Oligosaccharides Drives the Gut Microbiota Development and Improves Gut Maturation Markers: A Randomized Controlled Trial

Miroslava Bosheva et al.

Summary: This study investigated the effects of an infant formula containing five HMOs on gut maturation. The results showed that this formula can support the development of the intestinal immune system and gut barrier function, and shift the gut microbiome closer to that of breastfed infants.

FRONTIERS IN NUTRITION (2022)

添加到收藏夹

Article Nutrition & Dietetics

Host-microbial co-metabolites modulated by human milk oligosaccharides relate to reduced risk of respiratory tract infections

Francois-Pierre Martin et al.

Summary: Human milk oligosaccharides (HMOs) in breast milk, specifically 2-HMO (2'fucosyllactose, lacto-N-neotetraose), have been found to reduce the risk of lower respiratory tract infections (LRTIs) in infants. This study aimed to further investigate the molecular pathways linking 2-HMO formula feeding and LRTI mitigation. The researchers found that 2-HMO formula feeding increased gamma-glutamylation and N-acetylation of amino acids, while decreasing inflammatory signaling lipids. Additionally, specific Bifidobacterium and Bacteroides species were implicated in these metabolic changes. These findings contribute to our understanding of infant gut and microbiome metabolism and how it may impact immune competence.

FRONTIERS IN NUTRITION (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Utilization of industrial citrus pectin side streams for enzymatic production of human milk oligosaccharides

Tessa L. Biel-Nielsen et al.

Summary: This study demonstrates the utility of depectinized citrus residues as a valuable source of fucosylated xyloglucan for the production of 2' fucosyllactose. Enzymatic extraction of xyloglucan resulted in a narrower molecular weight distribution compared to alkaline extraction. The enzymatic extracts showed higher yields in transfucosylation reactions, making them preferable for this application.

CARBOHYDRATE RESEARCH (2022)

添加到收藏夹

Review Nutrition & Dietetics

Gastrointestinal Effects and Tolerance of Nondigestible Carbohydrate Consumption

Annemarie R. Mysonhimer et al.

Summary: Nondigestible carbohydrates (NDCs), classified as dietary fibers by the US FDA, are widely used in the food supply due to their beneficial effects on human health and product development. However, there are no specific recommendations for the intake of individual NDCs. This review provides tolerable intake dose recommendations for various NDCs based on their gastrointestinal effects, and suggests the need for further studies to test a wider range of doses and consumption forms.

ADVANCES IN NUTRITION (2022)

添加到收藏夹

Article Nutrition & Dietetics

Effects of addition of 2-fucosyllactose to infant formula on growth and specific pathways of utilization by Bifidobacterium in healthy term infants

John C. C. Wallingford et al.

Summary: A study found that adding 2'FL to infant formula did not affect infant growth or adverse events. However, the formula-fed group showed higher microbial richness and diversity after 16 weeks compared to the breastfed group. Additionally, the addition of 2'FL resulted in changes in certain microbial metabolic modules, similar to breastfed infants.

FRONTIERS IN NUTRITION (2022)

添加到收藏夹

Article Pediatrics

Infant formulas with synthetic oligosaccharides and respective marketing practices: Position Statement of the German Society for Child and Adolescent Medicine e.V. (DGKJ), Commission for Nutrition

Christoph Buehrer et al.

Summary: Human milk contains a variety of oligosaccharides, which vary in content and composition among individuals. These oligosaccharides are utilized by infants' intestinal bacteria, affecting bacterial composition and metabolism. Maternal secretor status and oligosaccharide content are associated with infection risk in breastfed infants. The safety of adding oligosaccharides to infant formula has been established, but the clinical benefits are still uncertain. Therefore, the use of synthetic oligosaccharides in infant formula is currently not recommended over formulas without additives.

MOLECULAR AND CELLULAR PEDIATRICS (2022)

添加到收藏夹

Article Pediatrics

The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Chhinder P. Sodhi et al.

Summary: The study showed that human milk oligosaccharides 2'-FL and 6'-SL can prevent NEC through inhibition of TLR4 signaling, while lactose cannot. The results indicate that these HMOs reduced NEC occurrence in mouse and piglet models.

PEDIATRIC RESEARCH (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

The Healthy Microbiome-What Is the Definition of a Healthy Gut Microbiome?

Fergus Shanahan et al.

Summary: Defining a healthy microbiome in different populations is crucial, but requires improved profiling technologies and understanding the variations and influences on the microbiome among apparently healthy individuals.

GASTROENTEROLOGY (2021)

添加到收藏夹

Article Nutrition & Dietetics

Growth, Tolerance, and Compliance of Infants Fed an Extensively Hydrolyzed Infant Formula with Added 2′-FL Fucosyllactose (2′-FL) Human Milk Oligosaccharide

Carlett Ramirez-Farias et al.

Summary: This study evaluated the effects of an extensively hydrolyzed formula with added 2'-FL on growth, tolerance, and compliance in infants. The results showed that the formula was well tolerated, safe, and supported growth in the intended population.

NUTRIENTS (2021)

添加到收藏夹

Review Immunology

Role of Human Milk Bioactives on Infants' Gut and Immune Health

Laura E. Carr et al.

Summary: Exclusive human milk feeding for the first 6 months is vital for optimal health outcomes in newborns, while adding HMOs to infant formula could enhance defense mechanisms. Current research has shown important knowledge about HMOs, milk microbiota, immunoglobulins, lactoferrin, and milk miRNAs, but there are still gaps in understanding the roles and interactions of different milk components.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Nutrition & Dietetics

The Effects of Human Milk Oligosaccharides on Gut Microbiota, Metabolite Profiles and Host Mucosal Response in Patients with Irritable Bowel Syndrome

Cristina Iribarren et al.

Summary: This study showed that supplementation with 2’FL/LNnT can alter the gut microbiota, fecal and plasma metabolite profiles in IBS patients. The increase in bifidobacteria abundance was associated with these changes, while there was no effect on the host mucosal response.

NUTRIENTS (2021)

添加到收藏夹

Article Nutrition & Dietetics

The need to study human milk as a biological system

Parul Christian et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

添加到收藏夹

Article Microbiology

Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

Martin F. Laursen et al.

Summary: Breastfeeding-associated Bifidobacterium species can convert aromatic amino acids into aromatic lactic acids via an unrecognized enzyme, potentially impacting infant immune function. Longitudinal study of Danish infants showed that faecal concentrations of aromatic lactic acids are positively correlated with specific Bifidobacterium species abundance containing the enzyme. These microbial metabolites may have implications for early life immune function.

NATURE MICROBIOLOGY (2021)

添加到收藏夹

Article Nutrition & Dietetics

Impact of 2′-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings

Jennifer Joan Ryan et al.

Summary: 2'-Fucosyllactose (2'-FL) has bifidogenic and butyrogenic effects, which can improve intestinal dysbiosis in patients with IBS and ulcerative colitis, leading to improvements in their quality of life.

NUTRIENTS (2021)

添加到收藏夹

Review Biochemical Research Methods

Engineered Microbial Routes for Human Milk Oligosaccharides Synthesis

Mengyao Lu et al.

Summary: Human milk oligosaccharides (HMOs) are important components in human milk, and the engineered microbial routes have been researched for large-scale production. The selection of host strains and expression of appropriate glycosyltransferase are key factors in HMOs production using engineered microbial pathways.

ACS SYNTHETIC BIOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Human Milk Oligosaccharides Modulate Fecal Microbiota and Are Safe for Use in Children With Overweight: A Randomized Controlled Trial

Cilius Esmann Fonvig et al.

Summary: This study found that both 2'FL and Mix are beneficial in increasing bifidobacteria in children's intestinal microbiota. Furthermore, supplementation with these substances is safe and well tolerated in children.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2021)

添加到收藏夹

Article Biochemical Research Methods

Novel Class of Human Milk Oligosaccharides Based on 6′-Galactosyllactose Containing N-Acetylglucosamine Branches Extended by Oligogalactoses

Franz-Georg Hanisch et al.

Summary: Human milk oligosaccharides (HMOs) have attracted much attention recently for their role as a prebiotic factor and essential component in infant nutrition related to innate immunity. A new class of HMOs with high-galactose (HG) content and novel structural features has been discovered, contributing to the understanding of human milk composition. Additionally, glycomic data from mass spectrometry analysis have been made available for further research and exploration in the GlycoPOST archive.

JOURNAL OF PROTEOME RESEARCH (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Gold standard for nutrition: a review of human milk oligosaccharide and its effects on infant gut microbiota

Shunhao Zhang et al.

Summary: Human milk oligosaccharides (HMOs) in human milk play a crucial role in infant growth and health by interacting with the gut microbiota to support beneficial bacteria growth, exhibit anti-pathogenic effects, and modulate intestinal epithelial cell response. Recent studies have shown the potential of HMOs in improving infant health and reducing disease risk, emphasizing the molecular basis of their beneficial effects.

MICROBIAL CELL FACTORIES (2021)

添加到收藏夹

Article Nutrition & Dietetics

Clinical Evaluation of 16-Week Supplementation with 5HMO-Mix in Healthy-Term Human Infants to Determine Tolerability, Safety, and Effect on Growth

Katja Parschat et al.

Summary: The study shows that adding 5HMO-Mix to infant formula has no negative impact on the growth of healthy term infants, and the subjects tolerate it well, producing effects similar to breastfeeding.

NUTRIENTS (2021)

添加到收藏夹

Review Immunology

Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents

Anais Rousseaux et al.

Summary: Human milk oligosaccharides (HMOs) in breastmilk play a crucial role in promoting beneficial effects on the microbiota, immune system, and epithelial barriers in infants, highlighting their potential as new therapeutic agents, especially in allergy prevention.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Microbiology

Human Milk Oligosaccharide-Stimulated Bifidobacterium Species Contribute to Prevent Later Respiratory Tract Infections

Shaillay Kumar Dogra et al.

Summary: The use of 2'-FL and LNnT formula feeding was associated with reduced risk of bronchitis and LRTI, as well as changes in gut microbiota composition in infants, indicating a potential link between HMOs and immune protection.

MICROORGANISMS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Human milk oligosaccharide 2'-fucosyllactose links feedings at 1 month to cognitive development at 24 months in infants of normal and overweight mothers

Paige K. Berger et al.

PLOS ONE (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Mo1320 IMPACT OF HUMAN MILK OLIGOSACCHARIDES ON THE GUT MICROBIOTA COMPOSITION FROM IRRITABLE BOWEL SYNDROME PATIENTS; A PARALLEL DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL

Louise K. Vigsnæs et al.

GASTROENTEROLOGY (2020)

添加到收藏夹

Article Microbiology

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics

Bernard Berger et al.

mBio (2020)

添加到收藏夹

Article Allergy

A randomized controlled trial of different young child formulas on upper respiratory and gastrointestinal tract infections in Chinese toddlers

Ting F. Leung et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double-blind, placebo-controlled study

Cristina Iribarren et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

添加到收藏夹

Review Nutrition & Dietetics

Infant Formula Supplemented with Biotics: Current Knowledge and Future Perspectives

Seppo Salminen et al.

NUTRIENTS (2020)

添加到收藏夹

Article Food Science & Technology

From lab bench to formulated ingredient: Characterization, production, and commercialization of human milk oligosaccharides

Clodagh Walsh et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

添加到收藏夹

Article Nutrition & Dietetics

A Partly Fermented Infant Formula with Postbiotics Including 3′-GL, Specific Oligosaccharides, 2′-FL, and Milk Fat Supports Adequate Growth, Is Safe and Well-Tolerated in Healthy Term Infants: A Double-Blind, Randomised, Controlled, Multi-Country Trial

Yvan Vandenplas et al.

NUTRIENTS (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Human Milk Oligosaccharides Support Normal Bowel Function and Improve Symptoms of Irritable Bowel Syndrome: A Multicenter, Open-Label Trial

Olafur S. Palsson et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2020)

添加到收藏夹

Proceedings Paper Nutrition & Dietetics

Human Milk Oligosaccharides: Structure and Functions

Lars Bode

MILK, MUCOSAL IMMUNITY AND THE MICROBIOME: IMPACT ON THE NEONATE (2020)

添加到收藏夹

Article Nutrition & Dietetics

Real-world study in infants fed with an infant formula with two human milk oligosaccharides

Enriqueta Roman Riechmann et al.

NUTRICION HOSPITALARIA (2020)

添加到收藏夹

Article Nutrition & Dietetics

Confirmed Hypoallergenicity of a Novel Whey-Based Extensively Hydrolyzed Infant Formula Containing Two Human Milk Oligosaccharides

Anna Nowak-Wegrzyn et al.

NUTRIENTS (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants

Chloe A. Autran et al.

GUT (2018)

添加到收藏夹

Review Nutrition & Dietetics

Infant formulae supplemented with prebiotics: Are they better than unsupplemented formulae? An updated systematic review!

Agata Skorka et al.

BRITISH JOURNAL OF NUTRITION (2018)

添加到收藏夹

Review Food Science & Technology

Human Milk Oligosaccharides as Promising Antivirals

Vasily Morozov et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Human Milk Oligosaccharides as Essential Tools for Basic and Application Studies on Galectins

Tadasu Urashima et al.

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY (2018)

添加到收藏夹

Review Pediatrics

Immunological Effects of Human Milk Oligosaccharides

Vassilis Triantis et al.

FRONTIERS IN PEDIATRICS (2018)

添加到收藏夹

Review Nutrition & Dietetics

Review of the Clinical Experiences of Feeding Infants Formula Containing the Human Milk Oligosaccharide 2 '-Fucosyllactose

Elizabeth J. Reverri et al.

NUTRIENTS (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity: A Randomized Multicenter Trial

Giuseppe Puccio et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Human Milk Oligosaccharides Influence Neonatal Mucosal and Systemic Immunity

Sharon M. Donovan et al.

ANNALS OF NUTRITION AND METABOLISM (2016)

添加到收藏夹

Article Nutrition & Dietetics

Oral supplementation of healthy adults with 2-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota

Emma Elison et al.

BRITISH JOURNAL OF NUTRITION (2016)

添加到收藏夹

Article Nutrition & Dietetics

Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2′-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial

Karen C. Goehring et al.

JOURNAL OF NUTRITION (2016)

添加到收藏夹

Article Medicine, General & Internal

Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

Cesar G. Victora et al.

LANCET (2016)

添加到收藏夹

Review Nutrition & Dietetics

Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application

Lars Bode et al.

NUTRITION REVIEWS (2016)

添加到收藏夹

Review Pediatrics

Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis

Bernardo L. Horta et al.

ACTA PAEDIATRICA (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Infants Fed a Lower Calorie Formula With 2′FL Show Growth and 2′FL Uptake Like Breast-Fed Infants

Barbara J. Marriage et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2015)

添加到收藏夹

Article Nutrition & Dietetics

Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas

Bo Loennerdal

AMERICAN JOURNAL OF CLINICAL NUTRITION (2014)

添加到收藏夹

Article Biochemical Research Methods

Detection of milk oligosaccharides in plasma of infants

L. Renee Ruhaak et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Direct Evidence for the Presence of Human Milk Oligosaccharides in the Circulation of Breastfed Infants

Karen C. Goehring et al.

PLOS ONE (2014)

添加到收藏夹

Review Gastroenterology & Hepatology

Stool characteristics of infants receiving short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides: A review

Petra A. M. J. Scholtens et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

添加到收藏夹

Article Nutrition & Dietetics

Urinary excretion of in vivo 13C-labelled milk oligosaccharides in breastfed infants

Silvia Rudloff et al.

BRITISH JOURNAL OF NUTRITION (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Human milk oligosaccharides: Every baby needs a sugar mama

Lars Bode

GLYCOBIOLOGY (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Diagnostic Approach and Management of Cow's-Milk Protein Allergy in Infants and Children: ESPGHAN GI Committee Practical Guidelines

S. Koletzko et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2012)

添加到收藏夹

Article Agriculture, Multidisciplinary

Consumption of Human Milk Oligosaccharides by Gut-Related Microbes

Angela Marcobal et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

David A. Sela et al.

TRENDS IN MICROBIOLOGY (2010)

添加到收藏夹

Article Gastroenterology & Hepatology

Treatment of helicobacter pylori infection using a novel antiadhesion compound (3′sialyllactose sodium salt).: A double blind, placebo-controlled clinical

F Parente et al.

HELICOBACTER (2003)

添加到收藏夹

Article Nutrition & Dietetics

Human milk oligosaccharides are minimally digested in vitro

MJ Gnoth et al.

JOURNAL OF NUTRITION (2000)

添加到收藏夹

Article Medicine, General & Internal

Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial

P Ukkonen et al.

LANCET (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.