期刊
NUTRIENTS
卷 15, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/nu15163622
关键词
infant formula; human milk oligosaccharide; clinical trial; growth; tolerance; safety; microbiome; immunity
This systematic review evaluates the health outcomes of clinical trials involving the supplementation of manufactured HMOs. The trials found that HMO supplementation is safe and well tolerated, with beneficial effects on gut health and immune system in infants and other populations. Further research is needed to substantiate these effects and understand their structure and dose dependency.
Human milk oligosaccharides (HMOs) are a major component of human milk. They are associated with multiple health benefits and are manufactured on a large scale for their addition to different food products. In this systematic review, we evaluate the health outcomes of published clinical trials involving the supplementation of manufactured HMOs. We screened the PubMed database and Cochrane Library, identifying 26 relevant clinical trials and five publications describing follow-up studies. The clinical trials varied in study populations, including healthy term infants, infants with medical indications, children, and adults. They tested eight different HMO structures individually or as blends in varying doses. All trials included safety and tolerance assessments, and some also assessed growth, stool characteristics, infections, gut microbiome composition, microbial metabolites, and biomarkers. The studies consistently found that HMO supplementation was safe and well tolerated. Infant studies reported a shift in outcomes towards those observed in breastfed infants, including stool characteristics, gut microbiome composition, and intestinal immune markers. Beneficial gut health and immune system effects have also been observed in other populations following HMO supplementation. Further clinical trials are needed to substantiate the effects of HMO supplementation on human health and to understand their structure and dose dependency.
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