☆ 4.7 Review

Ketogenic Diet and Breast Cancer: Recent Findings and Therapeutic Approaches

NUTRIENTS (2023)

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Editorial Material Biochemistry & Molecular Biology

Cancer chemotherapy

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CELL (2023)

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Article Oncology

Obesity and Breast Cancer: Interaction or Interference with the Response to Therapy?

Silvia Riondino et al.

Summary: This study aimed to identify a cut-off point of body mass index (BMI) that would have a significant prognostic impact on stage I-II BC patients receiving AI treatment. The results showed that a BMI cut-off >29 was associated with a deteriorating disease-free survival (DFS) in AI-treated BC patients, indicating that obesity is a risk factor for recurrence in breast cancer.

CURRENT ONCOLOGY (2023)

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Article Nutrition & Dietetics

Synergistic Effect of Squalene and Hydroxytyrosol on Highly Invasive MDA-MB-231 Breast Cancer Cells

Cristina Sanchez-Quesada et al.

Summary: A study found that the combination of hydroxytyrosol and squalene, two minor compounds in virgin olive oil, has antitumor effects on breast cancer cells. This suggests that the health-promoting properties of virgin olive oil may be a result of the combined action of various compounds.

NUTRIENTS (2022)

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Article Oncology

Identification of the most common BRCA alterations through analysis of germline mutation databases: Is droplet digital PCR an additional strategy for the assessment of such alterations in breast and ovarian cancer families?

Alessandro Lavoro et al.

Summary: Breast and ovarian cancer are the two most common tumor types in females worldwide. Various factors such as age, reproductive factors, and genetic factors are associated with the onset and progression of these cancers. Mutations in the tumor suppressor genes BRCA1 and BRCA2 can lead to increased cancer risk. Next-generation sequencing and droplet digital PCR are effective methods for assessing and detecting BRCA1/2 mutations.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Review Oncology

Associations of adiposity and weight change with recurrence and survival in breast cancer patients: a systematic review and meta-analysis

Yuanjie Pang et al.

Summary: Adiposity and weight change among breast cancer patients are associated with mortality, but there is limited evidence on the associations with distant recurrence or other causes of death or on central adiposity. Weight gain is also associated with recurrence and survival among breast cancer patients.

BREAST CANCER (2022)

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Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures

Dharambir Kashyap et al.

Biomed Research International (2022)

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Review Oncology

Analysis of risk factors associated with breast cancer in women: a systematic review and meta-analysis

Hulin Liu et al.

Summary: This study systematically reviewed the risk factors associated with breast cancer onset in Chinese women. It found that a history of benign breast disease, family history of breast cancer, menopause onset >50 years of age, and use of oral contraceptives were risk factors for breast cancer. On the other hand, the number of term pregnancies and breastfeeding were identified as protective factors for breast cancer.

TRANSLATIONAL CANCER RESEARCH (2022)

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Review Nutrition & Dietetics

Applications of Medium-Chain Triglycerides in Foods

Shinji Watanabe et al.

Summary: Research has shown that medium-chain triglycerides (MCTs) not only serve as an energy source, but also have various physiological effects on fat and protein metabolism. Ingesting MCTs can enhance fat oxidation, leading to reduced body fat and improved endurance during exercise. Additionally, MCTs promote protein synthesis, inhibit catabolism, and have potential applications in improving frailty in the elderly and dietary treatments.

FRONTIERS IN NUTRITION (2022)

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Review Oncology

Plant-Based and Ketogenic Diets As Diverging Paths to Address Cancer A Review

Urvi A. Shah et al.

Summary: This review suggests that plant-enriched diets are more effective than ketogenic diets in reducing cancer risk and improving metabolic disorders in cancer survivors. Additional clinical trials are needed to further investigate the effects of dietary modifications in the cancer population. The prioritization of plant-based diets is supported by current data, and future research may personalize dietary recommendations for individuals with cancer.

JAMA ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Potential Neurotoxic Effects of Glioblastoma-Derived Exosomes in Primary Cultures of Cerebellar Neurons via Oxidant Stress and Glutathione Depletion

Sidika Genc et al.

Summary: High-grade gliomas, specifically glioblastoma multiforme (GBM), are the deadliest brain tumors with poor survival rates and associated cognitive decline. This study reveals the toxic potential of GBM-derived exosomes to primary neurons, providing insights into peritumoral edema and cognitive decline in GBM patients.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis

Katie Lin et al.

Summary: This article reviews the molecular regulation of protooncogene and iNOS expression in breast cancer, explores the interrelationships between iNOS, HER2, BRCA1/2, and NO metabolism in the pathophysiology of cancer stem cells, and proposes further research into the regulatory mechanisms underlying iNOS and various breast cancer oncogenes.

ANTIOXIDANTS (2022)

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Review Nutrition & Dietetics

Supplementation of Regular Diet With Medium-Chain Triglycerides for Procognitive Effects: A Narrative Review

Ksenia Shcherbakova et al.

Summary: It is widely accepted that ketosis possesses neuroprotective effects and MCT supplementation has been proven to benefit individuals with normal cognition and cognitive disorders. MCFAs may directly impact the brain and participate in intertwined metabolic pathways with long-chain fatty acids and glucose.

FRONTIERS IN NUTRITION (2022)

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Review Biochemistry & Molecular Biology

Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

Huiyuan Zhu et al.

Summary: The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet that has shown therapeutic potential for various diseases. This review summarizes the evidence of its efficacy and safety, discusses the possible mechanisms of action, and suggests the need for randomized controlled trials to support its clinical use.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Nutrition & Dietetics

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks

Lee Crosby et al.

Summary: Very-low-carbohydrate ketogenic diets have been utilized to reduce seizure frequency and for various health conditions, but their impact on diet quality and potential risks should be considered, given the lack of long-term safety data and potentially temporary benefits.

FRONTIERS IN NUTRITION (2021)

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Article Nutrition & Dietetics

Quality of Life in Women Diagnosed with Breast Cancer after a 12-Month Treatment of Lifestyle Modifications

Concetta Montagnese et al.

Summary: The study showed that a healthy lifestyle program involving traditional Mediterranean diet and exercise for breast cancer survivors resulted in improved HRQoL, possibly by reducing body weight, while maintaining adequate vitamin D levels to alleviate breast cancer-related symptoms.

NUTRIENTS (2021)

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Article Environmental Sciences

Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up)

Trinidad Dierssen-Sotos et al.

Summary: This study found that a high intake of carbohydrates was associated with worse prognosis in normal-weight women with breast cancer, while a high intake of polyunsaturated fats may improve overall survival. Additionally, substituting carbohydrate intake with fat intake may have a protective effect in normal-weight women.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Fruit and vegetable consumption and incident breast cancer: a systematic review and meta-analysis of prospective studies

Maryam S. Farvid et al.

Summary: High total fruit and vegetable consumption are associated with reduced risk of overall, postmenopausal, ER+/PR+ and ER-/PR- breast cancer. Total fruit consumption and total vegetable intake are also linked to lower risk of specific types of breast cancer.

BRITISH JOURNAL OF CANCER (2021)

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Review Oncology

Ketogenic Diets and their Therapeutic Potential on Breast Cancer: A Systemic Review

Mohammed Jemal et al.

Summary: The ketogenic diet is a novel therapeutic approach that can increase the sensitivity of most cancers to standard therapies, potentially improving the antitumor effects of chemotherapy, overall safety, and quality of life. Studies have shown that the ketogenic diet can lower glucose and insulin levels necessary for tumor growth, making it a promising treatment option for various cancers.

CANCER MANAGEMENT AND RESEARCH (2021)

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Review Oncology

Endocrine Treatment for Breast Cancer Patients Revisited-History, Standard of Care, and Possibilities of Improvement

Naiba Nabieva et al.

Summary: Tamoxifen, aromatase inhibitors, and fulvestrant have been traditionally used for endocrine therapy in hormone-receptor-positive breast cancer patients, but with the approval of novel substances and the discovery of resistance mechanisms, the standards of endocrine treatment are evolving. Investigation into targeting signaling pathways and overcoming resistance is pushing endocrine treatment towards a new era.

CANCERS (2021)

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Article Nutrition & Dietetics

Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer

Ulrike Kaemmerer et al.

Summary: Both ketogenic diets and low carb diets are safe and beneficial for breast cancer patients during the rehabilitation phase, improving quality of life, body composition, and physical performance. Low carb diet participants showed the most significant improvement in quality of life aspects.

NUTRIENTS (2021)

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Review Nutrition & Dietetics

Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives

Natalia E. Cortez et al.

Summary: Ketogenic diets show potential impact on the treatment and mitigation of cachexia in PDAC, mimicking the metabolic changes of fasting with its low carbohydrate, moderate protein, and high fat composition. Studies indicate that ketogenic diets can reduce tumor growth and act as adjuvant therapy in cancer treatment.

NUTRIENTS (2021)

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Article Environmental Sciences

Genetic and Epigenetic Alterations Induced by Pesticide Exposure: Integrated Analysis of Gene Expression, microRNA Expression, and DNA Methylation Datasets

Federica Giambo et al.

Summary: Exposure to pesticides can result in alterations in gene and miRNA expression levels, as well as modulation of DNA methylation status, which may contribute to the development of various diseases.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Oncology

Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review

Sergiusz Lukasiewicz et al.

Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with molecular subtypes providing new insights into treatment strategies and patient stratifications that impact the management of breast cancer patients.

CANCERS (2021)

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Article Food Science & Technology

Evaluation of the Effects of Different Dietary Patterns on Breast Cancer: Monitoring Circulating Tumor Cells

Xiuxiu Wang et al.

Summary: The study found that high-salt, high-sugar, and high-fat diets significantly promoted the increase in CTC numbers, while ketogenic, low-fat, low-protein, diet restriction, and Mediterranean diets delayed the increase. Through in-depth study of the effects of different dietary patterns on tumor growth and metastasis, a new horizon in future cancer treatments may be expanded.

FOODS (2021)

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Review Biochemistry & Molecular Biology

Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities

Wamidh H. Talib et al.

Summary: The ketogenic diet has emerged as a metabolic therapy in cancer treatment targeting cancer cell metabolism. By reducing cell energy supplies, it inhibits tumor growth, showing potential antitumor effects. This diet could be used as a promising adjuvant in cancer therapy by creating an unfavorable metabolic environment for cancer cells.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2021)

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Review Endocrinology & Metabolism

Ketogenic diet in the treatment of cancer - Where do we stand?

Daniela D. Weber et al.

MOLECULAR METABOLISM (2020)

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Article Oncology

Association between meat consumption and risk of breast cancer: Findings from the Sister Study

Jamie J. Lo et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Alcohol Consumption by Beverage Type and Risk of Breast Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

Qiuyu Sun et al.

ALCOHOL AND ALCOHOLISM (2020)

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Carla Loreto et al.

CURRENT MOLECULAR MEDICINE (2020)

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Article Medicine, Research & Experimental

Effects of a ketogenic diet in overweight women with polycystic ovary syndrome

Antonio Paoli et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Cell Biology

Defense and protection mechanisms in lung exposed to asbestiform fiber: The role of macrophage migration inhibitory factor and heme oxygenase-1

Carla Loreto et al.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2020)

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Article Pediatrics

Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial

Vishal Sondhi et al.

JAMA PEDIATRICS (2020)

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Review Environmental Sciences

Breast Cancer Primary Prevention and Diet: An Umbrella Review

Alessandra Buja et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Article Multidisciplinary Sciences

Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial

Giuseppe Porciello et al.

PLOS ONE (2020)

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Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

Taxiarchis Konstantinos Nikolouzakis et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Luca Falzone et al.

CANCERS (2020)

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Review Oncology

Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment

Francesco Plotti et al.

CHEMOTHERAPY (2020)

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Article Oncology

Impact of a ketogenic diet intervention during radiotherapy on body composition: III-final results of the KETOCOMP study for breast cancer patients

Rainer J. Klement et al.

BREAST CANCER RESEARCH (2020)

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Article Clinical Neurology

Modified Atkins Diet with slow reduction of carbohydrate

Amanda Gauthier et al.

EPILEPSY & BEHAVIOR REPORTS (2020)

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Review Oncology

Triple-negative breast cancer molecular subtyping and treatment progress

Li Yin et al.

BREAST CANCER RESEARCH (2020)

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Ketogenic Diet and Microbiota: Friends or Enemies?

Antonio Paoli et al.

GENES (2019)

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Article Neurosciences

The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation

Chao Huang et al.

GLIA (2018)

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Article Nutrition & Dietetics

Ketogenic Ratio Determines Metabolic Effects of Macronutrients and Prevents Interpretive Bias

Tanya Zilberter et al.

FRONTIERS IN NUTRITION (2018)

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Review Biochemistry & Molecular Biology

Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease

Alessandro Pinto et al.

ANTIOXIDANTS (2018)

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Article Oncology

The potential contribution of dietary factors to breast cancer prevention

Niva Shapira

EUROPEAN JOURNAL OF CANCER PREVENTION (2017)

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Review Neurosciences

Ketogenic diet for epilepsy treatment

Leticia Pereira de Brito Sampaio

ARQUIVOS DE NEURO-PSIQUIATRIA (2016)

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Article Oncology

Female breast cancer in Central and South America

Alejandro Di Sibio et al.

CANCER EPIDEMIOLOGY (2016)

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Review Oncology

Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer

R. J. Klement et al.

ONCOGENESIS (2016)

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Article Biochemistry & Molecular Biology

Mitochondria: The ketogenic diet-A metabolism-based therapy

Silvia Vidali et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)

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Article Medicine, General & Internal

Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial A Randomized Clinical Trial

Estefania Toledo et al.

JAMA INTERNAL MEDICINE (2015)

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Review Reproductive Biology

Molecular Classification of Breast Carcinoma: From Traditional, Old-Fashioned Way to A New Age, and A New Way

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JOURNAL OF BREAST HEALTH (2015)

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Review Pathology

HER2 in Breast Cancer: A Review and Update

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ADVANCES IN ANATOMIC PATHOLOGY (2014)

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Review Oncology

Chemotherapy in Early Breast Cancer: When, How and Which One?

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Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies

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LIPIDS IN HEALTH AND DISEASE (2014)

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Article Multidisciplinary Sciences

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Tadahiro Shimazu et al.

SCIENCE (2013)

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Review Biochemistry & Molecular Biology

The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress

Peter Andrew C. McPherson et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2012)

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Article Oncology

Dramatic dietary fat reduction is feasible for breast cancer patients: Results of the randomised study, WINS (UK) - Stage 1

B. M. Parry et al.

EJSO (2011)

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Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet

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NEUROBIOLOGY OF DISEASE (2010)

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