Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran.

Automated summary

Rice bran, a by-product of rice milling, is rich in bioactive molecules and has health-promoting properties in improving metabolic conditions. This study aimed to optimize the extraction conditions of rice bran extract (RBE) and validate its impact on lipid metabolism. The optimized RBE showed significant benefits in reducing weight gain, hyperlipidemia, and hepatosteatosis in mouse models. The study also discovered that the administration of optimized RBE activated AMPK and inhibited STAT3, crucial players in liver lipid metabolism. Overall, optimized RBE holds promise as a dietary intervention against hyperlipidemia and hepatosteatosis.