4.7 Article

Shear-Viscosity-Dependent Effect of a Gum-Based Thickening Product on the Safety of Swallowing in Older Patients with Severe Oropharyngeal Dysphagia

期刊

NUTRIENTS
卷 15, 期 14, 页码 -

出版社

MDPI
DOI: 10.3390/nu15143279

关键词

thickening agent; thickening product; shear viscosity; shear rate; salivary amylase; dysphagia

向作者/读者索取更多资源

The study aimed to determine the therapeutic effect of the xanthan-gum-based thickener Tsururinko Quickly (TQ) in older patients with severe oropharyngeal dysphagia (OD). The results showed that TQ greatly improved the safety of swallowing and reduced the occurrences of penetration and aspiration in a shear-viscosity-dependent manner. The therapeutic range for TQ was found to be 100-800 mPa·s, with 200 and 800 mPa·s being the optimal doses for older patients with OD.
Fluid thickening is a valid therapeutic strategy for patients with oropharyngeal dysphagia (OD). The main aim of this study was to determine the therapeutic effect of the xanthan-gum-based thickener Tsururinko Quickly (TQ, Morinaga Milk Co., Tokyo, Japan) in older patients with severe OD. A total of 85 patients (83.32 & PLUSMN; 6.75 y) with OD and a penetration-aspiration score (PAS) of n & GE; 3 were studied by videofluoroscopy while swallowing duplicate 10 mL boluses at <50 mPa & BULL;s, 100, 200, 400, 800, and 1600 mPa & BULL;s, to assess the safety and efficacy of swallowing and the biomechanics of a swallowing response at each viscosity level. At <50 mPa & BULL;s, only 16.25% patients swallowed safely, 45% had penetrations (PAS 3-5), and 38.75% had aspirations (PAS 6-8). Fluid thickening with TQ greatly increased the prevalence of patients with safe swallowing from 62.90% at 100 mPa & BULL;s to 95.24% at 1600 mPa & BULL;s in a shear-viscosity-dependent manner. The penetrations and aspirations were significantly reduced to 3.60% and 1.19%, respectively, at 1600 mPa & BULL;s. The threshold viscosity was 100 mPa & BULL;s and the increasing viscosity above 800 mPa & BULL;s did not further improve the therapeutic effect significantly. Increasing the shear viscosity significantly reduced the time to laryngeal vestibule closure (-16.70%), increased the time to upper oesophageal sphincter opening (+26.88%), and reduced the pharyngeal bolus velocity (-31.62%) without affecting the pharyngeal residue. TQ has a strong shear-viscosity-dependent effect on the safety of swallowing in older patients with severe OD without increasing the pharyngeal residue. The therapeutic range for TQ is 100-800 mPa & BULL;s, with 200 and 800 mPa & BULL;s being the optimal doses to cover the needs of older patients with OD.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据