4.6 Review

Potential effects of assisted reproductive technology on telomere length and telomerase activity in human oocytes and early embryos

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Peripheral mitochondrial DNA, telomere length and DNA methylation as predictors of live birth in in vitro fertilization cycles

Letizia Li Piani et al.

Summary: This study investigated the potential of telomere length, mitochondrial-DNA, and DNA methylation patterns as reliable predictors of in-vitro fertilization success. The results suggest that DNA methylation patterns are significantly associated with IVF success, but the clinical usefulness of these associations is limited.

PLOS ONE (2022)

Article Cell Biology

Leukocyte Telomere Length Correlates with Extended Female Fertility

Jennia Michaeli et al.

Summary: The current trend of delayed reproduction in society calls for a better understanding of reproductive aging. This study found that longer leukocyte telomere length may be associated with higher oocyte quality and can serve as a potential biomarker for assessing reproductive potential.
Article Biochemistry & Molecular Biology

Impact of superovulation and in vitro fertilization on LINE-1 copy number and telomere length in C57BL/6 J mice blastocysts

Thalita S. Berteli et al.

Summary: Superovulation and in vitro fertilization (IVF) may result in genomic changes, including altered telomere length and activation of retrotransposon LINE-1. This study found that embryos produced through superovulation and IVF had significantly longer telomeres compared to embryos produced naturally. The implications of this enriched telomere length for the health and lifespan of IVF offspring deserve further investigation.

MOLECULAR BIOLOGY REPORTS (2022)

Article Medicine, General & Internal

Assessment of Telomere Length and Mitochondrial DNA Copy Number in Granulosa Cells as Predictors of Aneuploidy Rate in Young Patients

Tzu-Ning Yu et al.

Summary: The present study aims to investigate the correlation among female age, cellular aging markers, and aneuploidy rate. The results demonstrate that telomere length (TL) in granulosa cells is negatively correlated with the aneuploidy rate in the young-age group.

JOURNAL OF CLINICAL MEDICINE (2022)

Review Biochemistry & Molecular Biology

Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment

Ashok Agarwal et al.

Summary: This review discusses the in vitro conditions and environmental factors responsible for the induction of oxidative stress (OS) in assisted reproductive techniques (ARTs). OS has detrimental effects on gametes and embryos, necessitating strategies to ameliorate its impact during the entire embryo culture process.

ANTIOXIDANTS (2022)

Article Biochemistry & Molecular Biology

Leukocyte telomere length in children born following blastocyst-stage embryo transfer

Cheng Wang et al.

Summary: This study investigates the association between assisted reproductive technology (ART) and initial leukocyte telomere length (LTL) using whole-genome sequencing (WGS) data. The study finds that one-year-old children conceived by ART have shorter LTLs, especially in those conceived through blastocyst-stage embryo transfer. Mouse experiments also confirm that blastocyst-stage embryo transfer results in shorter telomere lengths.

NATURE MEDICINE (2022)

Article Genetics & Heredity

Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening

Fatma Uysal et al.

Summary: Telomere signal intensities decrease significantly from fetal to postmenopausal groups, with TERT, TRF1, TRF2, and POT1 proteins showing reduced expression levels in oocytes and granulosa cells. These findings suggest that decreased TERT and telomere-binding protein expression may contribute to telomere shortening in aging ovaries, potentially impacting female fertility. Further research is needed to understand the molecular mechanisms involved in this process.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

Article Multidisciplinary Sciences

Changes in telomere length and senescence markers during human ovarian tissue cryopreservation

Boram Kim et al.

Summary: This study aimed to evaluate the changes in telomere length and senescence markers during human ovarian tissue cryopreservation. The results showed a significant decrease in telomere length and alterations of senescence markers in ovarian tissues after cryopreservation.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

High Dosages of Equine Chorionic Gonadotropin Exert Adverse Effects on the Developmental Competence of IVF-Derived Mouse Embryos and Cause Oxidative Stress-Induced Aneuploidy

En Lin et al.

Summary: The study found that a high dose of 15 IU eCG reduced fertilization rates, increased the risk of chromosome aneuploidy, and negatively affected the developmental competence of IVF-obtained mouse embryos.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction and Oxidative Stress Caused by Cryopreservation in Reproductive Cells

Roberto Gualtieri et al.

Summary: Mitochondria play a crucial role in cell metabolism and ATP synthesis, while also being responsible for generating ROS and maintaining calcium homeostasis. Dysfunction in mitochondria can lead to oxidative stress, affecting cell function. Assisted reproductive technologies and cryopreservation may compromise mitochondrial function, impacting reproductive outcomes by affecting sperm and oocyte quality and fertilization dynamics.

ANTIOXIDANTS (2021)

Article Obstetrics & Gynecology

Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization

Brent M. Hanson et al.

Summary: The study revealed a significant relationship between WBC relative telomere length and increasing patient age as well as rates of embryonic aneuploidy, while no significant associations were found between CC relative telomere length and other outcomes assessed in this study. Further investigation into the relationship between WBC telomere length and aneuploidy is warranted.

FERTILITY AND STERILITY (2021)

Article Obstetrics & Gynecology

Does the additional use of clomiphene citrate or letrozole for in vitro fertilization deserve more attention?

Ying Liang et al.

Summary: Adding CC/LE to IVF ovulation induction has certain efficacy in terms of low cost and low OHSS incidence. CC/LE deserves more recommendations as a responsible strategy in high responders for advantageous pregnancy outcomes, while the strategy needs to be considered with more comprehensive factors in normal responders.

BMC PREGNANCY AND CHILDBIRTH (2021)

Article Obstetrics & Gynecology

Preconception leukocyte telomere length and pregnancy outcomes among women with demonstrated fecundity

Alexandra C. Purdue-Smithe et al.

Summary: This study examined whether preconception leukocyte telomere length was associated with fecundability, pregnancy loss, and live birth among women with a history of 1-2 prior pregnancy losses trying to conceive naturally. The results indicated that there was no significant association between preconception telomere length and these pregnancy outcomes.

HUMAN REPRODUCTION (2021)

Article Obstetrics & Gynecology

Telomere Shortening and Fusions: A Link to Aneuploidy in Early Human Embryo Development

Fabiana B. Kohlrausch et al.

Summary: This study focuses on the possible relationship between telomere dysfunction and aneuploidy in human early embryo development, discussing the mechanisms of aneuploidy caused by telomere shortening and fusion in human embryos. Research suggests that telomere length plays an important role in the development of the embryo and fetus, and abnormal shortening of telomeres may lead to embryo loss during early human development. Complications of assisted reproductive technology pregnancies may also be linked to telomere shortening.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2021)

Article Multidisciplinary Sciences

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

Peili Gu et al.

Summary: The human shelterin proteins POT1 and TPP1 form a stable heterodimer that protects telomere ends. Two functionally distinct POT1 proteins in mice have been identified, with POT1b enhancing telomerase recruitment to telomeres and coordinating the synthesis of telomeric G- and C-strands, while POT1a negatively regulates telomere length by inhibiting telomerase recruitment. The discovery of unique amino acids between POT1a and POT1b sheds light on the mechanistic basis for their different functions in regulating telomeres.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

Jekaterina Vohhodina et al.

Summary: The research demonstrates that BRCA1 binds TERRA RNA in an R-loop- and cell cycle-dependent manner, represses its transcription, prevents R-loop-associated damage, and promotes repair to maintain telomere stability.

NATURE COMMUNICATIONS (2021)

Review Oncology

Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma

Srishti Kotiyal et al.

Summary: Mutations in TERT promoter and CTNNB1 gene are common in hepatocellular carcinoma (HCC), and their interaction plays a role in promoting hepatocarcinogenesis.

CANCERS (2021)

Article Developmental Biology

Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF

George Anifandis et al.

Summary: Telomeres play a critical role in maintaining genome integrity by protecting chromosome ends, but their length decreases with age, leading to cellular senescence. Telomeres are closely related to male/female infertility and have been identified as a new biomarker for male infertility prediction. The interaction between telomeres and assisted reproduction is influenced more by the underlying cause of infertility rather than the actual procedure itself.

JOURNAL OF DEVELOPMENTAL BIOLOGY (2021)

Article Medicine, Research & Experimental

Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling

Yin Cai et al.

Summary: The study revealed that Rap1(-/-) mice exhibited signs of cardiac aging associated with telomere shortening and DNA damage, influencing cardiac fatty acid metabolism and aging-related phenotypes through modulation of the p53/PPAR alpha signaling pathway.

THERANOSTICS (2021)

Article Obstetrics & Gynecology

Cumulus cells have longer telomeres than leukocytes in reproductive-age women

Evelin E. Lara-Molina et al.

FERTILITY AND STERILITY (2020)

Article Public, Environmental & Occupational Health

Human fertility in relation to education, economy, religion, contraception, and family planning programs

Frank Gotmark et al.

BMC PUBLIC HEALTH (2020)

Review Chemistry, Medicinal

Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance

Connor A. H. Thompson et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Human RAP1 specifically protects telomeres of senescent cells from DNA damage

Liudmyla Lototska et al.

EMBO REPORTS (2020)

Article Biochemistry & Molecular Biology

Increasing telomerase enhanced steroidogenic genes expression and steroid hormones production in rat and human granulosa cells and in mouse ovary

Amitai Mordechai et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

Article Geriatrics & Gerontology

The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse

Esra Gozde Kosebent et al.

EXPERIMENTAL GERONTOLOGY (2020)

Article Genetics & Heredity

Impaired reproductive function and fertility preservation in a woman with a dyskeratosis congenita

LeRoy G. Robinson et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2020)

Review Biochemistry & Molecular Biology

Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks

Jia-Min Zhang et al.

CELL AND BIOSCIENCE (2020)

Review Biochemistry & Molecular Biology

The DNA secondary structures at telomeres and genome instability

Jun Tan et al.

CELL AND BIOSCIENCE (2020)

Review Biochemistry & Molecular Biology

G-Quadruplexes at Telomeres: Friend or Foe?

Tracy M. Bryan

MOLECULES (2020)

Review Biochemistry & Molecular Biology

Selection of competent oocytes by morphological criteria for assisted reproductive technologies

Saffet Ozturk

MOLECULAR REPRODUCTION AND DEVELOPMENT (2020)

Article Biochemistry & Molecular Biology

Superovulation alters global DNA methylation in early mouse embryo development

Bo Yu et al.

EPIGENETICS (2019)

Review Endocrinology & Metabolism

Individualization of FSH Doses in Assisted Reproduction: Facts and Fiction

Frank J. Broekmans

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Reproductive Biology

Shedding light into the relevance of telomeres in human reproduction and male factor infertility

Ana Catarina Lopes et al.

BIOLOGY OF REPRODUCTION (2019)

Review Cell Biology

Mitochondria, Telomeres and Telomerase Subunits

Qian Zheng et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Obstetrics & Gynecology

Effect of body mass index on the outcome of IVF cycles among patients with poor ovarian response

Ahmed M. Maged et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2019)

Review Cell Biology

Telomere Biology and Human Phenotype

Kara J. Turner et al.

Review Biochemistry & Molecular Biology

The effects of superovulation and reproductive aging on the epigenome of the oocyte and embryo

Kira L. Marshall et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2018)

Review Endocrinology & Metabolism

Impact of Maternal Age on Oocyte and Embryo Competence

Danilo Cimadomo et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Genetics & Heredity

Shelterin-Mediated Telomere Protection

Titia de Lange

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

Review Agriculture, Dairy & Animal Science

Telomere length and telomerase activity during folliculogenesis in mammals

Esra Gozde Kosebent et al.

JOURNAL OF REPRODUCTION AND DEVELOPMENT (2018)

Review Integrative & Complementary Medicine

Cryopreservation and its clinical applications

Tae Hoon Jang et al.

INTEGRATIVE MEDICINE RESEARCH (2017)

Review Biochemistry & Molecular Biology

Ovarian Stimulation Protocol in IVF: An Up-to-Date Review of the Literature

Alessandro Pacchiarotti et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Delphine Benarroch-Popivker et al.

MOLECULAR CELL (2016)

Article Obstetrics & Gynecology

Telomeres, Reproductive Aging, and Genomic Instability During Early Development

David L. Keefe

REPRODUCTIVE SCIENCES (2016)

Review Reproductive Biology

Telomerase Activity and Telomere Length in Male Germ Cells

Saffet Ozturk

BIOLOGY OF REPRODUCTION (2015)

Article Biochemistry & Molecular Biology

Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development

G. Anifandis et al.

CURRENT GENOMICS (2015)

Review Biochemistry & Molecular Biology

Role of TERRA in the Regulation of Telomere Length

Caiqin Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2015)

Article Genetics & Heredity

Cell-free DNA and telomere length among women undergoing in vitro fertilization treatment

J. Czamanski-Cohen et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

Article Biochemistry & Molecular Biology

Superovulation Induces Alterations in the Epigenome of Zygotes, and Results in Differences in Gene Expression at the Blastocyst Stage in Mice

Sarah Rose Huffman et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2015)

Article Obstetrics & Gynecology

Telomeres and Female Reproductive Aging

Keri Horan Kalmbach et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2015)

Article Cell Biology

Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births

Mary Herbert et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Multiple facets of TPP1 in telomere maintenance

Malligarjunan Rajavel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2014)

Article Public, Environmental & Occupational Health

Leukocyte Telomere Length and Age at Menopause

Kristen E. Gray et al.

EPIDEMIOLOGY (2014)

Review Obstetrics & Gynecology

Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice

Antonio La Marca et al.

HUMAN REPRODUCTION UPDATE (2014)

Review Biochemistry & Molecular Biology

Assisted Reproductive Technology Results: Why Are Live-Birth Percentages So Low?

Juan J. Tarin et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2014)

Article Multidisciplinary Sciences

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

Sujay Ray et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Telomere and Telomerase Biology

Miriam Aparecida Giardini et al.

TELOMERES IN HEALTH AND DISEASE (2014)

Article Obstetrics & Gynecology

Telomeres and human reproduction

Keri Horan Kalmbach et al.

FERTILITY AND STERILITY (2013)

Article Genetics & Heredity

Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss

J. Thilagavathi et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2013)

Article Developmental Biology

Telomere lengths in human pronuclei, oocytes and spermatozoa

S. Turner et al.

MOLECULAR HUMAN REPRODUCTION (2013)

Review Genetics & Heredity

The G4 Genome

Nancy Maizels et al.

PLOS GENETICS (2013)

Review Oncology

Alternative lengthening of telomeres: remodeling the telomere architecture

Dimitri Conomos et al.

FRONTIERS IN ONCOLOGY (2013)

Review Biotechnology & Applied Microbiology

It all comes together at the ends: Telomerase structure, function, and biogenesis

Joshua D. Podlevsky et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2012)

Article Genetics & Heredity

Biological pH buffers in IVF: help or hindrance to success

Matthew A. Will et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2011)

Article Biochemistry & Molecular Biology

Phenotypes in mTERT+/- and mTERT-/- Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

Margaret A. Strong et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Architecture of human telomerase RNA

Qi Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Genetics & Heredity

Telomere DNA Deficiency Is Associated with Development of Human Embryonic Aneuploidy

Nathan R. Treff et al.

PLoS Genetics (2011)

Review Cell Biology

Shelterin complex and associated factors at human telomeres

Raffaella Diotti et al.

NUCLEUS (2011)

Review Obstetrics & Gynecology

Embryo culture media for human IVF: which possibilities exist?

Irmhild Gruber et al.

JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION (2011)

Article Biochemistry & Molecular Biology

Dual effects of superovulation: loss of maternal and paternal imprinted methylation in a dose-dependent manner

Brenna A. Market-Velker et al.

HUMAN MOLECULAR GENETICS (2010)

Article Developmental Biology

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts

S. Turner et al.

MOLECULAR HUMAN REPRODUCTION (2010)

Review Cell Biology

Telomeres: protecting chromosomes against genome instability

Roderick J. O'Sullivan et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

InTERTpreting telomerase structure and function

Haley D. M. Wyatt et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemistry & Molecular Biology

POT1 Association with TRF2 Regulates Telomere Length

Megan F. Kendellen et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

How Telomeres Solve the End-Protection Problem

Titia de Lange

SCIENCE (2009)

Review Cell Biology

DNA damage response at functional and dysfunctional telomeres

Maria Pia Longhese

GENES & DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

Superovulation alters the expression of imprinted genes in the midgestation mouse placenta

Amanda L. Fortier et al.

HUMAN MOLECULAR GENETICS (2008)

Article Biochemistry & Molecular Biology

Distinct roles of TRF1 in the regulation of telomere structure and lengthening

Keiji Okamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Eros Lazzerini Denchi et al.

NATURE (2007)

Review Biochemistry & Molecular Biology

Telomeres and meiosis in health and disease

D. L. Keefe et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Article Biochemistry & Molecular Biology

Rap1 prevents telomere fusions by nonhomologous end joining

B Pardo et al.

EMBO JOURNAL (2005)

Review Endocrinology & Metabolism

Role of oxidative stress in female reproduction

A Agarwal et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2005)

Article Biochemistry & Molecular Biology

POT1 and TRF2 cooperate to maintain telomeric integrity

Q Yang et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

YJ Chiang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Microbiology

Human telomerase and its regulation

YS Cong et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2002)

Article Developmental Biology

Characterization of telomerase activity in the human oocyte and preimplantation embryo

DL Wright et al.

MOLECULAR HUMAN REPRODUCTION (2001)

Article Obstetrics & Gynecology

Superovulation of female mice delays embryonic and fetal development

I Van der Auwera et al.

HUMAN REPRODUCTION (2001)

Article Biochemistry & Molecular Biology

Induction of telomere shortening and replicative senescence by cryopreservation

S Honda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Obstetrics & Gynecology

The impact of ovarian stimulation on implantation and fetal development in mice

G Ertzeid et al.

HUMAN REPRODUCTION (2001)

Article Multidisciplinary Sciences

Telomere states and cell fates

EH Blackburn

NATURE (2000)

Article Biochemistry & Molecular Biology

Control of human telomere length by TRF1 and TRF2

A Smogorzewska et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)