☆ 4.3 Review

The efficacy and safety of microneedling with topical tranexamic acid for melasma treatment: A systematic review and meta-analysis

JOURNAL OF COSMETIC DERMATOLOGY (2023)

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Article Dermatology

Tranexamic acid microinjections versus tranexamic acid mesoneedling in the treatment of facial melasma: A randomized assessor-blind split-face controlled trial

Nazila Poostiyan et al.

Summary: This study compared the efficacy and safety of tranexamic acid (TXA) microinjections with TXA mesoneedling for facial melasma. The results showed that TXA mesoneedling was comparable to TXA microinjection in the treatment of facial melasma, but patient satisfaction was significantly higher with TXA mesoneedling. However, the high frequency of complications occurring with this treatment should be taken into account.

JOURNAL OF COSMETIC DERMATOLOGY (2023)

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Review Dermatology

Tranexamic acid in melasma: A focused review on drug administration routes

Hailey Konisky et al.

Summary: Melasma, a condition characterized by excessive pigmentation and vascularization, primarily affects women aged 20 to 40. The etiology of melasma remains unknown, but it frequently occurs in sun-exposed areas and is associated with family history, hormonal factors, medications, and UV exposure. Despite the use of topical hydroquinone, melasma often proves resistant to treatment. Tranexamic acid (TXA), a plasmin inhibitor, has shown promise as an off-label treatment for melasma. This review examines the various methods of TXA administration and their efficacy compared to traditional treatments. Oral, intralesional, and topical TXA have all demonstrated safety and efficacy in randomized controlled trials, with overall improvement in Melasma Area and Severity Index (MASI) scores. Oral TXA appears to be the most effective treatment, particularly for refractory melasma, although it may cause gastrointestinal side effects and menstrual irregularities. Intralesional injections and microneedling with topical TXA are effective alternatives to oral treatment, while topical TXA, although the least effective method, can be combined with other cosmeceuticals for improved outcomes. Furthermore, topical TXA is better tolerated than hydroquinone, a traditional topical treatment for melasma.

JOURNAL OF COSMETIC DERMATOLOGY (2023)

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Review Pharmacology & Pharmacy

Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders

Piyush Verma et al.

Summary: Tranexamic acid is a drug used for the treatment of hyperpigmentation, and topical administration is the most favorable route. However, low penetration and availability at target cells limit tranexamic acid's topical administration.

EXPERT OPINION ON DRUG DELIVERY (2023)

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Article Dermatology

Dermoscopic evaluation of tranexamic acid versus Vitamin C, with microneedling in the treatment of melasma: a comparative, split-face, single-blinded study

Asmaa Ibrahim Tahoun et al.

Summary: The study demonstrates the significant efficacy of using MN combined with TXA or Vit C in the treatment of melasma, helping to reduce pigmentation and improve patients' quality of life. Dermoscopic evaluation is crucial in selecting the optimal treatment for each patient.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Article Dermatology

Efficacy and Safety of tranexamic acid versus vitamin c after microneedling in treatment of melasma: Clinical and Dermoscopic study

Yasmina El Attar et al.

Summary: The use of topical tranexamic acid or vitamin C after microneedling is an effective and safe technique for melasma treatment, with significant improvements in pigmented lesions and vascular components.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

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Article Dermatology

A prospective randomized controlled trial of Q-switched Nd:YAG laser with topical 3% tranexamic acid (TA) versus microneedling with topical 3% tranexamic acid (TA) in treatment of melasma

Behera Debasmita et al.

Summary: This study compared the efficacy and side effects of microneedling and QS Nd:YAG laser when combined with topical 3% TA gel to treat melasma. Both treatments were equally effective in reducing mMASI, with no significant difference in patient satisfaction scores. Side effects for both interventions included erythema, pain, and burning sensation.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

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Review Dermatology

Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis

Adrian Joseph Michel Bailey et al.

Summary: This study conducted a systematic review and meta-analysis on the efficacy of microneedling as an adjuvant to topical therapies for the treatment of melasma. The results showed that microneedling as an adjuvant therapy improved melasma severity significantly, with better results compared to topical therapy alone. Microneedling was well tolerated with no serious adverse events reported.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Histological changes in facial melasma after treatment with triple combination cream with or without oral tranexamic acid and/or microneedling: A randomised clinical trial

Daniel Pinho Cassiano et al.

Summary: This study evaluated the histological changes promoted by triple combination cream in the treatment of melasma and found that complementary treatment with microneedling and oral tranexamic acid is beneficial for melasma. It is important to avoid damaging the skin barrier and stimulating angiogenesis in the treatment of melasma.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2022)

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Review Dermatology

Microneedling with cutaneous delivery of topical agents for the treatment of melasma: A systematic review

Jenifer Brasil dos Santos et al.

Summary: Microneedling can be used safely and effectively to reduce the severity of melasma and improve patients' quality of life.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

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Article Dermatology

Micro-needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split-face study

Khaled M. M. Mekawy et al.

Summary: The study found that micro-needling and fractional CO(2) laser are equally safe and effective for delivering tranexamic acid in the treatment of facial melasma. Both techniques significantly reduced the severity of melasma, with no statistically significant differences between them.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Pharmacology & Pharmacy

Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract

Mengzhen Xing et al.

Summary: The study showed the feasibility and significant effectiveness of tranexamic acid dissolving microneedles for treating melasma. Compared to solid microneedles, dissolving microneedles had higher release efficiency and better bioavailability. The combination of tranexamic acid and licorice extract demonstrated synergistic therapy benefits.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Efficacy and safety of tranexamic acid in the treatment of adult melasma: An updated meta-analysis of randomized controlled trials

Xiaowei Feng et al.

Summary: The study found that oral TXA is an effective and safe alternative treatment for melasma, with significant improvement in melasma regardless of the delivery route.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2021)

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Article Dermatology

Microneedling-assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: A split-face randomized study

Mohamed S. Zaky et al.

Summary: The study evaluated the effectiveness of topically applied tranexamic acid after microneedling versus topically applied hydroquinone 4% in treating melasma. Both methods demonstrated safety and efficacy with minimal side effects, with slightly better results seen with the application of hydroquinone according to raters and subjects.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Dermatology

Randomized, double-blind, placebo-controlled split-face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma

Damia Kuster Kaminski Arida et al.

Summary: Tranexamic acid delivered through microneedling did not provide additional benefit in the treatment of melasma.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Dermatology

Melasma: A critical analysis of clinical trials investigating treatment modalities published in the past 10 years

Natalia M. K. Spierings

JOURNAL OF COSMETIC DERMATOLOGY (2020)

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Article Dermatology

Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial

Susan Farshi et al.

JOURNAL OF COSMETIC DERMATOLOGY (2020)

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Article Dermatology

Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: A single-blind randomized clinical trial

Simin Shamsi Meymandi et al.

JOURNAL OF COSMETIC DERMATOLOGY (2020)

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Article Dermatology

Tranexamic Acid for Melasma Treatment: A Split-Face Study

Howyda M. Ebrahim et al.

DERMATOLOGIC SURGERY (2020)

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Article Dermatology

Clinical Efficacy of Topical Tranexamic Acid With Microneedling in Melasma

Amrit Kaur et al.

DERMATOLOGIC SURGERY (2020)

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Article Dermatology

The efficacy and safety of topical tranexamic acid (liposomal or lotion with microneedling) versus conventional hydroquinone in the treatment of melasma

Xiaoxue Xing et al.

JOURNAL OF COSMETIC DERMATOLOGY (2020)

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Review Dermatology

Future therapies in melasma: What lies ahead?

Rashmi Sarkar et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2020)

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Article Medicine, General & Internal

RoB 2: a revised tool for assessing risk of bias in randomised trials

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Dermatology

Topical tranexamic acid with microneedling versus microneedling alone in treatment of melasma: clinical, histopathologic, and immunohistochemical study

Fatma Saleh et al.

JOURNAL OF EGYPTIAN WOMENS DERMATOLOGICAL SOCIETY (2019)

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Letter Dermatology

Early clinical and histological changes induced by microneedling in facial melasma: A pilot study

Daniel Pinho Cassiano et al.

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY (2019)

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Article Medicine, General & Internal

Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma A randomized, self-controlled, split-face study

Yang Xu et al.

MEDICINE (2017)

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Review Dermatology

Microneedling: A Comprehensive Review

Angela Hou et al.

DERMATOLOGIC SURGERY (2017)

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Article Medicine, General & Internal

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Article Medicine, General & Internal

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

Jonathan A. C. Sterne et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Article Dermatology

Clinico-epidemiological Study and Quality of Life Assessment in Melasma

Ravali Yalamanchili et al.

INDIAN JOURNAL OF DERMATOLOGY (2015)

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Article Dermatology

Inflammatory features of melasma lesions in Asian skin

Tai Kyung Noh et al.

JOURNAL OF DERMATOLOGY (2014)

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Article Dermatology

Effect of tranexamic acid on melasma: a clinical trial with histological evaluation

J. I. Na et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2013)

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Article Dermatology

Reliability assessment and validation of the Melasma Area and Severity Index (MASI) and a new modified MASI scoring method

Amit G. Pandya et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2011)

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Article Dermatology

A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma

J. P. Ortonne et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2009)

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Review Medicine, General & Internal

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration

Alessandro Liberati et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

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Article Dermatology

The vascular characteristics of melasma

En Hyung Kim et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2007)

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Article Dermatology

Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation

D. Hexsel et al.

BRITISH JOURNAL OF DERMATOLOGY (2006)

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