期刊
BIOMEDICAL OPTICS EXPRESS
卷 14, 期 11, 页码 5946-5964出版社
Optica Publishing Group
DOI: 10.1364/BOE.499354
关键词
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The combination of PS-OCT and BRM allows for the evaluation of myelinated axons at different spatial scales, making it promising for studying brain connectivity and organization.
The combination of polarization-sensitive optical coherence tomography (PS-OCT) and birefringence microscopy (BRM) enables multiscale assessment of myelinated axons in postmortem brain tissue, and these tools are promising for the study of brain connectivity and organization. We demonstrate label-free imaging of myelin structure across the mesoscopic and microscopic spatial scales by performing serial-sectioning PS-OCT of a block of human brain tissue and periodically sampling thin sections for high-resolution imaging with BRM. In co-registered birefringence parameter maps, we observe good correspondence and demonstrate that BRM enables detailed validation of myelin (hence, axonal) organization, thus complementing the volumetric information content of PS-OCT.
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