Solvent-dependent hypsochromic shift and ameliorative effects on breast cancer-induced bone metastases associated oxidative injury in rats

A sulfate-bridged complex [Cu(m2-SO4)(Im)4] (1) was prepared and structurally charac-terized, where Im: imidazole. The X-ray structure analysis reveals that 1 crystallizes in the mono-clinic system with space group C2/c. The octahedral coordination around the metal center is made up of four distinct imine nitrogen atoms in the equatorial plane, and two sulfate oxygen atoms occupying the axial sites. The covalent linkage between metals via the sulfate group, forming infinite 1D zigzag chains, ensures the entanglement of the structure. These chains, in turn, are further assembled into a 2D network through NAH center dot center dot center dot O hydrogen bonding. Thermal analyses underline the high thermal stability of our complex, which starts to decompose at 200 degrees C. The infrared spec-trum confirms the results obtained from the crystallographic analysis. Optical studies reveal the presence of a hypsochromic effect noticed in the absorption and photoluminescence spectra. The synthesized compound was found to reduce both oxidative injury and histopathological features, which are associated with skeletal metastases as a result of malignant Walker 256/B breast cancer cells.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Automated summary

A sulfate-bridged copper complex with high thermal stability and therapeutic properties against skeletal metastases in breast cancer cells was synthesized. The structure analysis revealed a 1D chain-like structure interconnected by covalent sulfate linkages and a 2D network formed through hydrogen bonding. Optical studies demonstrated a hypsochromic effect in the absorption and photoluminescence spectra of the compound.