4.4 Editorial Material

Commentary on: BIA-ALCL Epidemiology in an Aesthetic Breast Surgery Cohort of 1501 Patients

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Article Surgery

Enhancing Patient Outcomes in Aesthetic Breast Implant Procedures Using Proven Antimicrobial Breast Pocket Irrigations: A 20-Year Follow-up

Aniketh Venkataram et al.

Summary: This study is the largest and longest review of capsular contracture (CC) in a controlled, single-surgeon setting. The study found that antimicrobial breast pocket irrigation is effective and practical in reducing the incidence of CC, with the Betadine regimen preferred. Universal adoption of Betadine-containing antimicrobial breast pocket irrigation is recommended to reduce CC and other device-associated infections.

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AESTHETIC SURGERY JOURNAL (2023)

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BIA-ALCL Epidemiology in an Aesthetic Breast Surgery Cohort of 1501 Patients

Jerzy Kolasinski et al.

Summary: This study investigated the occurrence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 1501 patients who received cosmetic breast augmentation between 2006 and 2016. The study found a higher prevalence of BIA-ALCL compared to previous reports, especially among patients with macrotextured devices. The importance of accurate follow-up for patients was confirmed.

AESTHETIC SURGERY JOURNAL (2023)

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From embodiment to evidence: The harmful intersection of poor regulation of medical implants and obstructed narratives in embodied experiences of failed metal-on-metal hips

Pauline McCormack

Summary: This research presents the findings of a study on patients with failed metal-on-metal hip implants, exploring the intersection of poor regulation with patients' narratives of pain and the denial of their experiences and restoration. By obstructing patient narratives, the regulatory system undermines the evidence needed for effective operation. Patient narratives serve as the basis for scientific evidence of widespread implant failure.

HEALTH (2023)

Article Oncology

Gram-Negative Bacterial Lipopolysaccharide Promotes Tumor Cell Proliferation in Breast Implant-Associated Anaplastic Large-Cell Lymphoma

Maria Mempin et al.

Summary: This study demonstrates that bacteria, rather than the implants themselves, can trigger the activation and multiplication of BIA-ALCL cancer cells in vitro. The unique response of BIA-ALCL cells to bacterial lipopolysaccharide (LPS) stimulation suggests a novel pathway for LPS to promote cancer cell proliferation via a Toll-like receptor 4 (TLR4) receptor-mediated bacterial transformation of T-cells into malignancy.

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JAMA INTERNAL MEDICINE (2020)

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Analysis of Allergan's Biocell Implant Recall in a Major University Breast Center

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Breast Implant-Associated Anaplastic Large Cell Lymphoma

P. Rastogi et al.

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