期刊
ACS CATALYSIS
卷 13, 期 16, 页码 10751-10755出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.3c02461
关键词
gold catalysis; acetylene; aryloxycyclization; chromanes; enantioselectivecatalysis
In this study, a new method was developed for the reaction of acetylene gas with o-allylphenols, resulting in the formation of chromanes through nucleophilic regioselective opening of cyclopropyl gold(I)-carbene intermediates. The synthetic application of this method was demonstrated in the late-stage functionalization of the natural product lapachol.
Acetylene gas isan important feedstock for chemical production,although it is underutilized in organic synthesis. We have developedan intermolecular gold(I)-catalyzed alkyne/alkene reaction of o-allylphenols with acetylene gas that gives rise to chromanesby a stereospecific aryloxycyclization through the nucleophilic regioselectiveopening of cyclopropyl gold(I)-carbene intermediates. The syntheticapplication of this method was demonstrated in the late-stage functionalizationof the natural product lapachol.
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