4.8 Article

Axially Chiral 2-Hydroxybiaryls by Palladium-Catalyzed Enantioselective C-H Activation

期刊

ACS CATALYSIS
卷 13, 期 21, 页码 13994-13999

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.3c03867

关键词

C-H activation; catalysis; palladium; enantioselective; atroposelective; phenol; naphthol; atropoisomers

向作者/读者索取更多资源

This article describes the discovery and development of a palladium-catalyzed asymmetric C-H olefination of 2-hydroxybiaryls. The strategy allows a direct assembly of optically active, axially chiral 2-substituted-2'-hydroxybiaryls from readily available precursors and demonstrates the efficiency of the native hydroxy unit as a directing group for the C-H activation. Compared to other methods that require preinstallation of metal coordinating units, this approach offers simplicity and versatility, enabling the practical and efficient synthesis of a wide variety of optically active binaphthyl derivatives.
This article describes the discovery and development of a palladium-catalyzed asymmetric C-H olefination of 2-hydroxybiaryls. The strategy allows a direct assembly of optically active, axially chiral 2-substituted-2 '-hydroxybiaryls from readily available precursors and demonstrates that the native hydroxy unit of the substrates can work as an efficient directing group for the C-H activation. This represents a substantial advantage over other approaches that require the preinstallation of metal coordinating units. The simplicity of the approach and versatility of the products allow a practical and efficient synthesis of a broad variety of optically active binaphthyl derivatives.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据