☆ 4.8 Article

Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

NATURE COMMUNICATIONS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+T cell responses post SARS-CoV-2 infection

Fei Gao et al.

Summary: T cells play a crucial role in the immune response to SARS-CoV-2, but their behavior after infection and vaccination is not well understood. This study examined the T cell responses of subjects receiving the Pfizer/BioNTech BNT162b2 vaccine. Vaccination induced strong spike-specific T cell responses for both CD4+ and CD8+ T cells, with CD4+ responses peaking 1 week after the second dose and CD8+ responses peaking 2 weeks later. These T cell responses were higher than those observed in COVID-19 patients. Additionally, prior SARS-CoV-2 infection was found to decrease CD8+ T cell activation and expansion, suggesting an influence of previous infection on the T cell response to vaccination.

IMMUNITY (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

Daan K. J. Pieren et al.

Summary: Resident memory T cells at the respiratory tract are important for early SARS-CoV-2 viral clearance. mRNA vaccination induces specific T cell responses in the lung, but the frequency and functionality of these cells are lower compared to convalescent patients.

NATURE COMMUNICATIONS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

Sam Afkhami et al.

Summary: The study found that using adenoviral vectors with a multivalent vaccine through intranasal immunization can generate better mucosal immune responses, including local and systemic antibody responses, mucosal tissue-resident memory T cells, and mucosal trained innate immunity, and provide protection against multiple viral variants.

CELL (2022)

添加到收藏夹

Review Immunology

Tissue resident memory T cells in the respiratory tract

Ming Z. M. Zheng et al.

Summary: Tissue-resident memory (Trm) cells in the respiratory tract play a crucial role in local immune responses against infections. Factors influencing the development, longevity, and immune surveillance of Trm cells were discussed, along with vaccination regimes harnessing these cells as new strategies to combat future global pandemics.

MUCOSAL IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Leo Swadling et al.

Summary: Research suggests that some individuals can clear potential SARS-CoV-2 infection after exposure, with T cells playing a role in the process. Studying healthcare workers who tested negative for antibodies revealed that they had stronger and more diverse memory T cells, with a focus on RTC.

NATURE (2022)

添加到收藏夹

Review Immunology

The T cell immune response against SARS-CoV-2

Paul Moss

Summary: T cell immunity plays a central role in controlling SARS-CoV-2 infection, with early responses correlating with protection. T cell memory provides broad recognition of viral proteins, limiting the impact of viral variants and offering protection against severe disease. Current COVID-19 vaccines elicit robust T cell responses, contributing to the prevention of hospitalization or death. Therefore, the importance of T cell immunity may have been underestimated.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

Anna H. E. Roukens et al.

Summary: Systemic immune cell dynamics during COVID-19 have been well-documented, but less is known about immune cells in the respiratory tract. This study characterized nasal and systemic immune cells in COVID-19 patients, showing increased inflammatory cells in the nasal mucosa during acute infection. After recovery, nasal immune cells mostly normalized, but SARS-CoV-2-specific CD8(+) T cells could persist for at least 2 months.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants

Timothy A. Bates et al.

Summary: This study found that individuals who previously recovered from COVID-19 and received vaccination (hybrid immunity) have enhanced immune responses. The effects of post-vaccination breakthrough infections on humoral immune response needs further investigation. However, regardless of whether it occurs before or after vaccination, natural infection substantially boosts the quantity, quality, and breadth of humoral immune response.

SCIENCE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Thirteen-Valent Pneumococcal Conjugate Vaccine-Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung

Elena Mitsi et al.

Summary: This study found that immunization with 13-valent pneumococcal conjugate vaccine elicits serotype-specific immunoglobulin G (IgG) responses, with serum IgG levels to correlate with those measured in bronchoalveolar lavage samples, but shows poor immunogenicity against serotype 3 in both sites.

JOURNAL OF INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Clinical Neurology

Serological response to SARS-CoV-2 vaccination in multiple sclerosis patients treated with fingolimod or ocrelizumab: an initial real-life experience

S. Guerrieri et al.

Summary: This study found variable antibody production in multiple sclerosis patients receiving fingolimod or ocrelizumab treatments after receiving a complete SARS-CoV-2 vaccination course. Clinical features did not show a clear correlation with serological response. There is currently insufficient data to recommend against COVID-19 vaccination in these patients.

JOURNAL OF NEUROLOGY (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

Joey Ming Er Lim et al.

Summary: Nasal-resident T cells specific for SARS-CoV-2 were detected in vaccinated individuals only after infection, highlighting the significance of nasal challenge in the formation of antiviral immunity at the site of infection.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination

Aloysious Ssemaganda et al.

Summary: This study investigates T cells in the nasal mucosa and blood after vaccination with the Pfizer-BioNTech COVID-19 vaccine. The results show an increase in tissue-resident memory CD8(+) T cells expressing CD69(+)CD103(+) in the nasal mucosa after the first and second doses, while CD69(+)CD103(+)CD8(+) T cells in the blood decrease post-vaccination. There is also an increase in nasal CD8(+)CD69(+)CD103(-) T cells, particularly following the second dose. Additionally, CD4(+) cells co-expressing CCR6 and CD161 are increased in abundance following both doses. Stimulation of nasal CD8(+) T cells with SARS-CoV-2 spike peptides elevates expression of CD107a and cytokines.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Review Immunology

Resident Memory B Cells in Barrier Tissues

Choong Man Lee et al.

Summary: Epithelial barriers constitute the body's front line of defense, and recent evidence highlights the important role of tissue-resident memory B cells in the lungs in rapid and strong defensive responses.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination

Jinyi Tang et al.

Summary: SARS-CoV-2 mRNA vaccination induces strong immune responses in the circulation, but its effectiveness in the respiratory tract, especially against variants of concern like Omicron, is still uncertain. This study found lower neutralizing antibody responses in the respiratory tract of vaccinated individuals compared to COVID-19 convalescents, despite robust antibody responses in the blood. Vaccination also induced circulating B and T cell immunity, but these responses were absent in the respiratory tract. Mouse immunization experiments showed that systemic mRNA vaccination alone resulted in weak respiratory mucosal neutralizing antibody responses, but combining it with mucosal adenovirus-S immunization produced strong neutralizing antibody responses against both the ancestral virus and the Omicron variant. Overall, this study suggests that current COVID-19 vaccines are highly effective against severe disease, but provide limited protection against breakthrough infections, particularly by the Omicron sublineage.

SCIENCE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

Mariana O. Diniz et al.

Summary: T cells can contribute to clearance of respiratory viruses and provide long-lasting protection. Pre-existing cross-reactive T cell responses play a crucial role in resisting infection. Airway-resident T cells with cross-reactivity to SARS-CoV-2 have been found in healthy individuals, suggesting their potential use in mucosal vaccines.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses

Tianyang Mao et al.

Summary: This study developed a vaccine strategy called prime and spike, which activates mucosal immune memory within the respiratory tract and induces strong immune responses. It enhances both systemic and local immunity against SARS-CoV-2, and provides full protection against lethal infection in partially immune mice.

SCIENCE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Kaori Sano et al.

Summary: This study reveals that prior SARS-CoV-2 infection enhances the induction of mucosal SARS-CoV-2 secretory IgA antibody following mRNA vaccination, while individuals without prior exposure to the virus have a minimal mucosal antibody response.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Medicine, General & Internal

Tolerability and immunogenicity of an intranasally- administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial

Meera Madhavan et al.

Summary: The study conducted a Phase I clinical trial on intranasal vaccination with ChAdOx1 nCoV-19. The results showed that intranasal administration of ChAdOx1 nCoV-19 was well-tolerated but did not induce consistent mucosal antibody responses or strong systemic immune responses. Some participants developed symptomatic SARS-CoV-2 infection after vaccination.

EBIOMEDICINE (2022)

添加到收藏夹

Article Immunology

Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination

Yacine Maringer et al.

Summary: This study compares the induction and functionality of T cell immunity after COVID-19 vaccination, finding that different vaccination regimens can induce broad and long-lasting spike-specific CD4(+) and CD8(+) T cell immunity to SARS-CoV-2. Booster vaccination has a particular relevance in improving antibody response.

SCIENCE IMMUNOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2

Elena Mitsi et al.

Summary: This study investigated the relationship between SARS-CoV-2 and Streptococcus pneumoniae in different populations, and found that pneumococcal infection reduces host immune responses to the virus.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

Review Immunology

Regulatory B cells in respiratory health and diseases

Madhvi Menon et al.

Summary: B cells play crucial roles in airway immune responses through antibody production, antigen presentation, and cytokine secretion, while regulatory B cells exert immunosuppressive functions via diverse mechanisms. The balance between effector and regulatory B cell functions is essential for maintaining immune homeostasis. Abnormalities in Breg numbers and function are associated with different respiratory disorders, highlighting the importance of Bregs in respiratory health maintenance.

IMMUNOLOGICAL REVIEWS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer et al.

Summary: A single dose of the ChAdOx1 nCoV-19 vaccine can induce favorable immune responses that may help control or prevent SARS-CoV-2 infection.

NATURE MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

添加到收藏夹

Article Cell Biology

IgA dominates the early neutralizing antibody response to SARS-CoV-2

Delphine Sterlin et al.

Summary: The study found that humoral immune responses to SARS-CoV-2 infection are dominated by IgA antibodies, with specific IgA plasmablasts rapidly expanding shortly after symptom onset and peaking in the third week of the disease. Virus-specific antibody responses include IgG, IgM, and IgA, with IgA playing a greater role in virus neutralization compared to IgG.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Immunology

Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

Young Min Son et al.

Summary: The study reveals a population of tissue-resident helper T cells in the lung, termed as T-RH cells, which play a critical role in promoting the development of protective B cell and CD8(+) T cell responses. These T-RH cells are dependent on transcription factors BCL6 and Bhlhe40 and deliver local help to CD8(+) T cells through IL-21-dependent mechanisms.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

Peter A. Szabo et al.

Summary: This study investigated the immune responses in the respiratory tract and blood of severe COVID-19 patients, revealing that T cells in the airways showed protective profiles while myeloid cells exhibited hyperinflammatory signatures. These findings provide important insights for understanding and treating COVID-19 lung pathology.

IMMUNITY (2021)

添加到收藏夹

Letter Medicine, General & Internal

Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

Florian Krammer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

Dennis Lapuente et al.

Summary: The study demonstrates that priming with systemic mRNA and boosting with intranasal adenoviral vector vaccine in mice induces comprehensive T cell and mucosal immunity. The strategy provides complete protection against SARS-CoV-2 infection in mice after boosting.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Maya M. L. Poon et al.

Summary: Research has shown that SARS-CoV-2-specific immune memory persists in organs for up to 6 months post-infection, with lungs and lymph nodes being the most prevalent sites, indicating coordinated local tissue immunity for protection against future infections.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA

Ji Eun Oh et al.

Summary: Research shows that intranasal immunization induces local IgA secretion in the bronchoalveolar space, providing effective protection against respiratory virus infections; single-cell RNA sequencing reveals a heterogeneous population of IgA-expressing cells within the respiratory mucosa, including tissue-resident memory B cells, plasmablasts, and plasma cells.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

Catherine J. Reynolds et al.

Summary: Vaccination with a single dose of BNT162b2 after prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants. In contrast, individuals without prior infection showed reduced immunity against variants after receiving a single vaccine dose.

SCIENCE (2021)

添加到收藏夹

Review Immunology

Local memory CD4 T cell niches in respiratory viral infection

Kurt B. Pruner et al.

Summary: Respiratory viral infections pose a major threat to global health and prosperity, with local immunity in the lung generated through resident memory immune subsets providing rapid responses to secondary infections and protection from heterologous infections.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Ugur Sahin et al.

Summary: The BNT162b2 vaccine shows 95% efficacy in preventing COVID-19 by boosting neutralizing antibody titres and activating specific T cell responses. The vaccine-induced immune response is broad and stable, lasting for a prolonged period, providing good coverage against various SARS-CoV-2 variants.

NATURE (2021)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

Hybrid immunity

Shane Crotty

SCIENCE (2021)

添加到收藏夹

Article Cell Biology

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

Neeltje van Doremalen et al.

Summary: Intranasal vaccination with ChAdOx1 nCoV-19/AZD1222 reduced viral loads in nasal swabs in vaccinated macaques and hamsters challenged with SARS-CoV-2, indicating potential for further investigation as a vaccination route for COVID-19 vaccines.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Cell Biology

Co-Ordination of Mucosal B Cell and CD8 T Cell Memory by Tissue-Resident CD4 Helper T Cells

Young Min Son et al.

Summary: This article discusses the importance of memory CD8 T and B cells in protecting respiratory mucosa from secondary microbial invasion, with a focus on the role of tissue-resident helper T cell populations in this process.

CELLS (2021)

添加到收藏夹

Article Immunology

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

Julia Niessl et al.

Summary: The study found that in individuals who had not been exposed to SARS-CoV-2, the frequencies of SARS-CoV-2-specific memory CD4(+) T cells were similar in tonsils and peripheral blood, but functional SARS-CoV-2-specific memory CD8(+) T cells were mostly found in tonsils. This suggests that preexisting tissue-resident memory CD8(+) T cells in unexposed individuals could potentially mount rapid immune responses against SARS-CoV-2.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

Ahmed O. Hassan et al.

Summary: The study demonstrates the immunogenicity and protective efficacy of an intranasally administered vaccine in non-human primates, showing that it induces neutralizing antibodies and T cell responses, effectively limiting or preventing infection of SARS-CoV-2 in the respiratory tract.

CELL REPORTS MEDICINE (2021)

添加到收藏夹

Article Critical Care Medicine

Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

Elena Mitsi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Alba Grifoni et al.

CELL (2020)

添加到收藏夹

Editorial Material Immunology

Serum IgA, IgM, and IgG responses in COVID-19

Huan Ma et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Letter Respiratory System

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Hai-qiong Yu et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

Ahmed O. Hassan et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Nina Le Bert et al.

NATURE (2020)

添加到收藏夹

Article Immunology

The establishment of resident memory B cells in the lung requires local antigen encounter

S. Rameeza Allie et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Airway T cells protect against RSV infection in the absence of antibody

E. Kinnear et al.

MUCOSAL IMMUNOLOGY (2018)

添加到收藏夹

Article Respiratory System

Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591)

Seher Raza Zaidi et al.

BMC PULMONARY MEDICINE (2017)

添加到收藏夹

Article Virology

Tissue resident memory T cells and viral immunity

Pamela C. Rosato et al.

CURRENT OPINION IN VIROLOGY (2017)

添加到收藏夹

Article Immunology

Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection

Angela Pizzolla et al.

SCIENCE IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

Jincun Zhao et al.

IMMUNITY (2016)

添加到收藏夹

Article Immunology

Modeling pneumococcal nasopharyngeal acquisition as a function of anticapsular serum antibody concentrations after pneumococcal conjugate vaccine administration

Ron Dagan et al.

VACCINE (2016)

添加到收藏夹

Article Immunology

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

Yu Adachi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

RSV-specific airway resident memory CD8+T cells and differential disease severity after experimental human infection

Agnieszka Jozwik et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Cell Biology

Lung-resident memory CD8 T cells ( TRM) are indispensable for optimal crossprotection against pulmonary virus infection

Tao Wu et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2014)

添加到收藏夹

Article Immunology

Lung niches for the generation and maintenance of tissue-resident memory T cells

D. L. Turner et al.

MUCOSAL IMMUNOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

Tom M. Wilkinson et al.

NATURE MEDICINE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

Taishi Onodera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Immunology

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

John R. Teijaro et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.