FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation

Article Cell & Tissue Engineering

Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells

Alejandro J. Chibly et al.

Summary: The disruption of neurotrophin signaling post-radiation inhibits the regeneration of irradiated salivary glands, potentially due to the upregulation of neurotrophin receptors in myoepithelial cells.

NPJ REGENERATIVE MEDICINE (2023)

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Article Cell Biology

A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the developing mouse salivary gland

Lemonia Chatzeli et al.

Summary: The development of the mouse salivary gland involves a process of branching morphogenesis, in which progenitor cells transition from a multipotent state to unipotent states via two distinct bipotent states. Notch signaling and Kras activation play important roles in promoting specific lineages. These findings provide insights into the mechanisms underlying lineage segregation and ductal patterning.

DEVELOPMENTAL CELL (2023)

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Review Oncology

A meta-analysis of palifermin efficacy for the management of oral mucositis in patients with solid tumours and haematological malignancy

John Coutsouvelis et al.

Summary: This study synthesizes published literature on the use of Palifermin for the management of oral mucositis in patients receiving chemotherapy and/or radiotherapy. The meta-analysis suggests that Palifermin can significantly reduce the incidence of severe mucositis.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Article Multidisciplinary Sciences

Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease

Ana Caroline Costa-da-Silva et al.

Summary: Diagnosis and treatment of oral cGVHD have been challenging, but this study identified a potential biomarker ZG16B in saliva and salivary gland that could serve as an early diagnostic indicator for oral cGVHD, highlighting the importance of early intervention in oral diseases.

ISCIENCE (2022)

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Article Multidisciplinary Sciences

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Robert C. Jones et al.

Summary: The molecular characterization of cell types using single-cell transcriptome sequencing has led to a revolution in cell biology and provided new insights into the physiology of human organs. In this study, a human reference atlas was created, consisting of nearly 500,000 cells from 24 different tissues and organs, allowing for the molecular characterization of over 400 cell types, their tissue distribution, and tissue-specific variation in gene expression. By using multiple tissues from the same donor, the clonal distribution of T cells, tissue-specific mutation rate in B cells, and the analysis of cell cycle state and proliferative potential of shared cell types across tissues were identified. Additionally, cell type-specific RNA splicing was discovered and analyzed within an individual.

SCIENCE (2022)

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Article Cell Biology

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Olivier Mauduit et al.

Summary: FGF10 plays a critical role in fetal organ development, and our study reveals that both mesenchymal and epithelial cells express FGF10 in the salivary gland. Specifically, epithelial FGF10 cells are specialized ionocytes important for the ionic modification of saliva.

CELL REPORTS (2022)

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Article Multidisciplinary Sciences

Long-term functional regeneration of radiation- damaged salivary glands through delivery of a neurogenic hydrogel

Jianlong Li et al.

Summary: Researchers have found that radiation-damaged salivary glands can be functionally regenerated using the neurogenic muscarinic receptor agonist Cevimeline. By continuously delivering Cevimeline-alginate hydrogel, the innervated acini can be regenerated and physiological saliva secretion can be restored over the long term.

SCIENCE ADVANCES (2022)

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Review Physiology

SALIVARY GLAND FUNCTION, DEVELOPMENT, AND REGENERATION

Alejandro M. Chibly et al.

Summary: Understanding the structure and function of salivary glands and their response to disease and injury can guide the development of therapies to repair and regenerate them. Recent advances in the OMICS field provide insights for using cell and gene therapies as well as bioengineering approaches to restore salivary function.

PHYSIOLOGICAL REVIEWS (2022)

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Review Multidisciplinary Sciences

Phenotypic spectrum of FGF10 -related disorders: a systematic review

Katarzyna Bzdega et al.

Summary: FGF10 is an important regulator in cell proliferation, multi-organ development, and tissue injury repair. Abnormalities involving FGF10 are associated with various human congenital disorders. However, the exact mechanism of FGF10 and its phenotypic heterogeneity remain incompletely understood.

PEERJ (2022)

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Article Cell Biology

Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

Alison J. May et al.

Summary: Neuronal-epithelial cross-talk drives acinar specification through NRG1-ERBB3-mTORC2 signaling. NRG1-ERBB3 regulates the cellular programs of lineage progression, secretion, and polarization through the mTORC2 signaling pathway. This mechanism plays a crucial role in the formation of functional acini.

DEVELOPMENTAL CELL (2022)

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Review Developmental Biology

Exocrine gland structure-function relationships

Sameed Khan et al.

Summary: Fluid secretion is crucial for the survival of mammals, and each glandular unit has its own unique structure and function. This article reviews the structural characteristics of glandular organs, discusses the impact of developmental defects on secretory function, and explores how knowledge of structure-function relationships can be applied to diagnostics, regenerative approaches, and tissue regeneration.

DEVELOPMENT (2022)

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Review Medicine, Research & Experimental

New developments in the biology of fibroblast growth factors

David M. Ornitz et al.

Summary: This review provides an overview of the fibroblast growth factor (FGF) family and focuses on new developments in the field since 2015. Highlights of the past 6 years include advancements in experimental modulation of FGF signaling, clinical use of small molecule FGFR inhibitors, expanded understanding of endocrine FGF signaling, and the roles of FGF signaling in stem cells, tissue homeostasis, regeneration, and neuropsychiatric diseases.

WIRES MECHANISMS OF DISEASE (2022)

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Article Dentistry, Oral Surgery & Medicine

A Ser252Trp substitution in mouse FGFR2 results in hyperplasia of embryonic salivary gland parenchyma

Tsukasa Watanabe et al.

Summary: Mutations in the FGFR2 gene lead to severe craniosynostotic disorders, with patients presenting symptoms such as hypersalivation. In a mouse model of Apert syndrome, increased FGFR1 signaling and apoptosis at E15.5 resulted in hyperplasia of the submandibular gland parenchyma.

JOURNAL OF ORAL BIOSCIENCES (2021)

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Review Cell & Tissue Engineering

The evolving definition of salivary gland stem cells

Cecilia Rocchi et al.

Summary: Dysfunction of salivary gland and irreversible hyposalivation are common side effects of head and neck cancer radiotherapy, impacting patient's quality of life significantly. Research suggests that various cell types within the salivary gland epithelium can act as stem/progenitor-like cells, potentially contributing to tissue regeneration after damage. Recent advances in adult stem cell research are reshaping our understanding of salivary gland stem cells and their plasticity in response to damage, offering new insights for the development of therapeutic strategies to address radiation-induced hyposalivation.

NPJ REGENERATIVE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 infection of the oral cavity and saliva

Ni Huang et al.

Summary: The study highlights the potential role of the oral cavity in COVID-19 pathogenesis, with evidence of SARS-CoV-2 infection and transmission via saliva. Viral shedding dynamics in saliva correlated with symptoms, and asymptomatic individuals were found to harbor sustained salivary antibodies against SARS-CoV-2 post-recovery.

NATURE MEDICINE (2021)

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Review Physiology

THE FGF/FGFR SYSTEM IN THE PHYSIOPATHOLOGY OF THE PROSTATE GLAND

Arianna Giacomini et al.

Summary: Fibroblast growth factors (FGFs) are a family of proteins that play a role in various biological processes, from embryonic development to cancer. They are important in the physiopathology of the prostate gland, ranging from embryonic development to modulation of neoplastic transformation.

PHYSIOLOGICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration

Cecilia Rocchi et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Article Environmental Sciences

Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice

Jeong Mi Kim et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Article Multidisciplinary Sciences

Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development

Belinda R. Hauser et al.

ISCIENCE (2020)

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Article Cell Biology

Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Marie Saitou et al.

CELL REPORTS (2020)

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Review Biochemistry & Molecular Biology

FGF/FGFR signaling in health and disease

Yangli Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Cell & Tissue Engineering

Sox10 Regulates Plasticity of Epithelial Progenitors toward Secretory Units of Exocrine Glands

Harleen K. Athwal et al.

STEM CELL REPORTS (2019)

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Review Genetics & Heredity

Structural Biology of the FGF7 Subfamily

Allen Zinkle et al.

FRONTIERS IN GENETICS (2019)

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Article Cell & Tissue Engineering

FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

Tingting Yuan et al.

STEM CELL REPORTS (2019)

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Article Cell Biology

Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse

Xin Gao et al.

PHYSIOLOGICAL GENOMICS (2018)

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Article Anatomy & Morphology

Maldevelopment of the submandibular gland in a mouse model of apert syndrome

Kojiro Yamaji et al.

DEVELOPMENTAL DYNAMICS (2018)

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Article Multidisciplinary Sciences

Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance

Eun-Ah Christine Song et al.

SCIENTIFIC REPORTS (2018)

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Article Cell Biology

Limited Regeneration of Adult Salivary Glands after Severe Injury Involves Cellular Plasticity

Pei-Lun Weng et al.

CELL REPORTS (2018)

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Article Oncology

Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction

Jeong-Seok Choi et al.

ONCOTARGET (2017)

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Article Biology

SOX2 regulates acinar cell development in the salivary gland

Elaine Emmerson et al.

ELIFE (2017)

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Review Anatomy & Morphology

Overview of Human Salivary Glands: Highlights of Morphology and Developing Processes

Fernanda de Paula et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2017)

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Article Dentistry, Oral Surgery & Medicine

Identification of Stem Cells in the Secretory Complex of Salivary Glands

M. Kwak et al.

JOURNAL OF DENTAL RESEARCH (2016)

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Article Medicine, Research & Experimental

Salivary Gland Dysplasia in Fgf10 Heterozygous Mice: A New Mouse Model of Xerostomia

A. J. May et al.

CURRENT MOLECULAR MEDICINE (2015)

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Review Dentistry, Oral Surgery & Medicine

Salivary Glands: Stem Cells, Self-duplication, or Both?

M. H. Aure et al.

JOURNAL OF DENTAL RESEARCH (2015)

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Review Developmental Biology

The Fibroblast Growth Factor signaling pathway

David M. Ornitz et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2015)

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Article Developmental Biology

FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis

Xiaohong Zhang et al.

DEVELOPMENT (2014)

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Review Cell Biology

Salivary gland development: A template for regeneration

Vaishali N. Patel et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

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Article Biology

Dynamic relationship of the epithelium and mesenchyme during salivary gland initiation: the role of Fgf10

Kirsty L. Wells et al.

BIOLOGY OPEN (2013)

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Article Cell & Tissue Engineering

Combined KIT and FGFR2b Signaling Regulates Epithelial Progenitor Expansion during Organogenesis

Isabelle M. A. Lombaert et al.

STEM CELL REPORTS (2013)

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Article Oncology

Prevention of Radiation-Induced Salivary Hypofunction Following hKGF Gene Delivery to Murine Submandibular Glands

Changyu Zheng et al.

CLINICAL CANCER RESEARCH (2011)

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Article Cell Biology

Localization of AQP5 during development of the mouse submandibular salivary gland

Helga S. Larsen et al.

JOURNAL OF MOLECULAR HISTOLOGY (2011)

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Article Biochemistry & Molecular Biology

Directed Expression of Cre in Alveolar Epithelial Type 1 Cells

Per Flodby et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

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Article Cell Biology

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

Jingxuan Yang et al.

JOURNAL OF CELL BIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation

Vaishali N. Patel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Cell & Tissue Engineering

Keratinocyte Growth Factor Prevents Radiation Damage to Salivary Glands by Expansion of the Stem/Progenitor Pool

Isabelle M. A. Lombaert et al.

STEM CELLS (2008)

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Review Cell Biology

Salivary gland development

A. S. Tucker

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2007)

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Review Biochemistry & Molecular Biology

Receptor specificity of the fibroblast growth factor family - The complete mammalian FGF family

Xiuqin Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Review Cell Biology

Salivary gland branching morphogenesis

Vaishali N. Patel et al.

DIFFERENTIATION (2006)

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Article Developmental Biology

FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis

T Jaskoll et al.

BMC DEVELOPMENTAL BIOLOGY (2005)

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Article Developmental Biology

FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis

Z Steinberg et al.

DEVELOPMENT (2005)

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Article Anatomy & Morphology

Embryonic submandibular gland morphogenesis: Stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice

T Jaskoll et al.

CELLS TISSUES ORGANS (2002)

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Article Developmental Biology

Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice

S Yoshida et al.

DEVELOPMENTAL BIOLOGY (2001)

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FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation

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