相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)
Frances Karla Kusuma et al.
Nature Communications (2023)
DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
Sara Sepe et al.
EMBO REPORTS (2022)
ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats
Lukas Frank et al.
NUCLEIC ACIDS RESEARCH (2022)
Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers
Robert Lu et al.
OPEN BIOLOGY (2022)
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
Nicole Kaminski et al.
MOLECULAR CELL (2022)
TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch
Tribhuwan Yadav et al.
MOLECULAR CELL (2022)
G4 Matters-The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides
Carolina Roxo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Antisense technology: an overview and prospectus
Stanley T. Crooke et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
ALT Positivity in Human Cancers: Prevalence and Clinical Insights
Danny MacKenzie et al.
CANCERS (2021)
TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
Bruno Silva et al.
NATURE COMMUNICATIONS (2021)
G-quadruplexes mark alternative lengthening of telomeres
Sunny Y. Yang et al.
NAR CANCER (2021)
Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies
Thomas Kent et al.
FRONTIERS IN ONCOLOGY (2020)
Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres
Taylor K. Loe et al.
GENES & DEVELOPMENT (2020)
ATR Inhibition Broadly Sensitizes Soft-Tissue Sarcoma Cells to Chemotherapy Independent of Alternative Lengthening Telomere (ALT) Status
Audrey Laroche-Clary et al.
SCIENTIFIC REPORTS (2020)
Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
Jia-Min Zhang et al.
CELL AND BIOSCIENCE (2020)
The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications
Marta Recagni et al.
CANCERS (2020)
Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy
Catia Rebelo de Almeida et al.
COMMUNICATIONS BIOLOGY (2020)
m5C modification of mRNA serves a DNA damage code to promote homologous recombination
Hao Chen et al.
NATURE COMMUNICATIONS (2020)
Selective Elimination of Osteosarcoma Cell Lines with Short Telomeres by Ataxia Telangiectasia and Rad3-Related Inhibitors
Tomas Goncalves et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)
Two replication fork remodeling pathways generate nuclease substrates for distinct fork protection factors
W. Liu et al.
SCIENCE ADVANCES (2020)
Zebrafish patient avatars in cancer biology and precision cancer therapy
Maurizio Fazio et al.
NATURE REVIEWS CANCER (2020)
Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends
Song My Hoang et al.
TRENDS IN CANCER (2020)
The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
Jeongkyu Kim et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways
Jia-Min Zhang et al.
CELL REPORTS (2019)
Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52
Jaewon Min et al.
GENES & DEVELOPMENT (2019)
TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1
Harikleia Episkopou et al.
MOLECULAR CELL (2019)
The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
Robert Lu et al.
NATURE COMMUNICATIONS (2019)
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
Bruno Silva et al.
NATURE COMMUNICATIONS (2019)
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Fabio Pessina et al.
NATURE CELL BIOLOGY (2019)
SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
Stephanie Panier et al.
MOLECULAR CELL (2019)
Non-enzymatic roles of human RAD51 at stalled replication forks
Jennifer M. Mason et al.
NATURE COMMUNICATIONS (2019)
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome
Julio Aguado et al.
NATURE COMMUNICATIONS (2019)
ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition
Dalal Bakhos-Douaihy et al.
Oncotarget (2019)
FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops
Xiaolei Pan et al.
SCIENTIFIC REPORTS (2019)
Telomere Length Maintenance in Cancer: At the Crossroad between Telomerase and Alternative Lengthening of Telomeres (ALT)
Marco De Vitis et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Shelterin-Mediated Telomere Protection
Titia de Lange
ANNUAL REVIEW OF GENETICS, VOL 52 (2018)
BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
Giuseppina D'Alessandro et al.
NATURE COMMUNICATIONS (2018)
Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms
Alaina R. Martinez et al.
GENES CHROMOSOMES & CANCER (2017)
A Cisplatin Derivative Tetra-Pt(bpy) as an Oncotherapeutic Agent for Targeting ALT Cancer
Xiao-hui Zheng et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
The C-Circle Assay for alternative-lengthening-of-telomeres activity
Jeremy D. Henson et al.
METHODS (2017)
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
Flavia Michelini et al.
NATURE CELL BIOLOGY (2017)
FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres
Xiaolei Pan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
A damaged genome's transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
Fabio Iannelli et al.
NATURE COMMUNICATIONS (2017)
A method for measuring the distribution of the shortest telomeres in cells and tissues
Tsung-Po Lai et al.
NATURE COMMUNICATIONS (2017)
DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
Francesca Rossiello et al.
NATURE COMMUNICATIONS (2017)
53BP1 and BRCA1 control pathway choice for stalled replication restart
Yixi Xu et al.
ELIFE (2017)
A Cisplatin Derivative Tetra-Pt(bpy) as an Oncotherapeutic Agent for Targeting ALT Cancer
Xiao-hui Zheng et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres
Alexander P. Sobinoff et al.
EMBO JOURNAL (2017)
Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin
Jigar N. Bandaria et al.
CELL (2016)
Break-induced telomere synthesis underlies alternative telomere maintenance
Robert L. Dilley et al.
NATURE (2016)
Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
Marc Hafner et al.
NATURE METHODS (2016)
Telomeric RNAs are essential to maintain telomeres
Juan Jose Montero et al.
NATURE COMMUNICATIONS (2016)
SMARCAL1 Resolves Replication Stress at ALT Telomeres
Kelli E. Cox et al.
CELL REPORTS (2016)
Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition
Katharina I. Deeg et al.
FRONTIERS IN ONCOLOGY (2016)
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells
Mahesh Ramamoorthy et al.
CANCER CELL (2015)
Preventing replication fork collapse to maintain genome integrity
David Cortez
DNA REPAIR (2015)
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Ralph Zellweger et al.
JOURNAL OF CELL BIOLOGY (2015)
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
Rachel Litman Flynn et al.
SCIENCE (2015)
Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX
David Clynes et al.
NATURE COMMUNICATIONS (2015)
ATRX represses alternative lengthening of telomeres
Christine E. Napier et al.
ONCOTARGET (2015)
A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT)
Maya Jeitany et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
ALTernative Telomere Maintenance and Cancer
Robert L. Dilley et al.
TRENDS IN CANCER (2015)
Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
Nam Woo Cho et al.
CELL (2014)
Causes and consequences of replication stress
Michelle K. Zeman et al.
NATURE CELL BIOLOGY (2014)
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1
Roderick J. O'Sullivan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination
Dimitri Conomos et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways
Da-Ping Xu et al.
NEUROCHEMISTRY INTERNATIONAL (2014)
Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes
Michael Lee et al.
NUCLEIC ACIDS RESEARCH (2014)
Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin
Harikleia Episkopou et al.
NUCLEIC ACIDS RESEARCH (2014)
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Lorenzo Costantino et al.
SCIENCE (2014)
RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
Rajika Arora et al.
NATURE COMMUNICATIONS (2014)
Site-specific DICER and DROSHA RNA products control the DNA-damage response
Sofia Francia et al.
NATURE (2012)
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
Courtney A. Lovejoy et al.
PLOS GENETICS (2012)
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution
Yuwen Ke et al.
EMBO JOURNAL (2011)
Mammalian 5′ C-Rich Telomeric Overhangs Are a Mark of Recombination-Dependent Telomere Maintenance
Liana Oganesian et al.
MOLECULAR CELL (2011)
Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids
Erik B. Pedersen et al.
NUCLEIC ACIDS RESEARCH (2011)
Altered Telomeres in Tumors with ATRX and DAXX Mutations
Christopher M. Heaphy et al.
SCIENCE (2011)
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D. Goldberg et al.
CELL (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
Agnel Sfeir et al.
CELL (2009)
Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells
Akira Nabetani et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
The DNA-damage response in human biology and disease
Stephen P. Jackson et al.
NATURE (2009)
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity
Jeremy D. Henson et al.
NATURE BIOTECHNOLOGY (2009)
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions
Anthony J. Cesare et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
CpG-island promoters drive transcription of human telomeres
Solomon G. Nergadze et al.
RNA (2009)
An oncogene-induced DNA damage model for cancer development
Thanos D. Halazonetis et al.
SCIENCE (2008)
Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
Claus M. Azzalin et al.
SCIENCE (2007)
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference
W-Q Jiang et al.
ONCOGENE (2007)
Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response
JN Sarkaria et al.
CLINICAL CANCER RESEARCH (2006)
Alternative lengthening of telomeres is characterized by high rates of telomeric exchange
JA Londoño-Vallejo et al.
CANCER RESEARCH (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
U Herbig et al.
MOLECULAR CELL (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
Systematic discovery of multicomponent therapeutics
AA Borisy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Alternative lengthening of telomeres in mammalian cells
JD Henson et al.
ONCOGENE (2002)
Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells
H Varley et al.
NATURE GENETICS (2002)
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
C Schaffitzel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Abnormal nuclear shape in solid tumors reflects mitotic instability
D Gisselsson et al.
AMERICAN JOURNAL OF PATHOLOGY (2001)