Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application

The topology type and the functionalization of pores play an important role in regulating the performance of covalent organic frameworks. Herein, we designed and synthesized the covalent organic framework with hetero-environmental pores using predesigned asymmetrical dialdehyde monomer. According to the results of structural characterization, crystallinity investigation, and theoretical calculation, the hetero-environmental pores of the obtained framework are regarded as the alternant arrangement. The distinctive hetero pore structure leads the designed material to show more advantages as compared with control materials in loading both hydrophobic and hydrophilic antibiotics for wound healing. This dual-antibiotic strategy can expand the antibacterial range as compared with the single antibiotic one, and reduce the generation of drug resistance. In summary, this strategy for designing covalent organic frameworks with hetero-environmental pores can extend the structural variety and provide a pathway for improving the practical application performance of these materials. The characteristics of the pores are vital for controlling the performance of covalent organic frameworks, but obtaining different chemical environments in different pores is challenging. Here, the authors report the development of covalent organic frameworks with differing pore environments.

Automated summary

In this study, covalent organic frameworks with hetero-environmental pores were designed and synthesized. The distinctive hetero pore structure of the framework exhibited advantages in loading both hydrophobic and hydrophilic antibiotics for wound healing. This dual-antibiotic strategy expanded the antibacterial range and reduced drug resistance. Designing covalent organic frameworks with hetero-environmental pores can extend structural variety and improve practical application performance of these materials.