4.8 Article

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3

Yiwei Gao et al.

Nature Communications (2023)

Article Multidisciplinary Sciences

Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Ananyo Choudhury et al.

Summary: Genetic associations and polygenic scores for lipid traits have limited transferability to African individuals. However, this study demonstrates that larger datasets and better global representation in discovery GWAS can help bridge this gap. The researchers identified a novel LDL-C association and a triglyceride association signal in African populations, supporting the importance of including African data in lipid trait studies. The study also found that the transferability of signals improves with an increase in the size of the African replication cohort.

NATURE COMMUNICATIONS (2022)

Article Biochemical Research Methods

Flashfm-ivis: interactive visualization for fine-mapping of multiple quantitative traits

Feng Zhou et al.

Summary: flashfm-ivis provides an interactive visualization tool to view potential causal genetic variants and compare associations between different quantitative traits. Its unique features, such as network diagrams and regional association plots, allow users to explore the joint effects across traits.

BIOINFORMATICS (2022)

Article Multidisciplinary Sciences

The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham et al.

Summary: This study conducted a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. The findings demonstrate that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction, with modest gains in the number of discovered loci and ancestry-specific variants. This highlights the importance of including diverse populations in genetic studies to improve the accuracy and equity of polygenic scores in clinical practice.

NATURE (2021)

Article Multidisciplinary Sciences

The flashfm approach for fine-mapping multiple quantitative traits

N. Hernandez et al.

Summary: Joint fine-mapping leveraging information between quantitative traits improves accuracy and resolution. Flashfm fine-maps signals for multiple traits using summary statistics, allowing for missing trait measurements and use of related individuals.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer

Sofia Christakoudi et al.

Summary: This study conducted a genome-wide association study of body shape indices and identified novel genetic variants associated with body shape, particularly highlighting the importance of genes related to visceral adipose tissue and adrenal cell renewal. The findings also revealed gender-specific genetic associations, with region-specific variants associated with different body shape indices in women and men.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Francois Aguet et al.

SCIENCE (2020)

Article Genetics & Heredity

Genome-wide association study of blood lipids in Indians confirms universality of established variants

Khushdeep Bandesh et al.

JOURNAL OF HUMAN GENETICS (2019)

Article Biochemistry & Molecular Biology

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa

Deepti Gurdasani et al.

Article Multidisciplinary Sciences

The transferability of lipid loci across African, Asian and European cohorts

Karoline Kuchenbaecker et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia

Jamal Jafari et al.

BIOMEDICINES (2019)

Article Public, Environmental & Occupational Health

Gender and Race Disparities in Cardiovascular Disease Risk Factors among New York City Adults: New York City Health and Nutrition Examination Survey (NYC HANES) 2013-2014

Rania Kanchi et al.

JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE (2018)

Article Genetics & Heredity

Multi-trait analysis of genome-wide association summary statistics using MTAG

Patrick Turley et al.

NATURE GENETICS (2018)

Review Cardiac & Cardiovascular Systems

Cardiovascular disease in Africa: epidemiological profile and challenges

Ashley K. Keates et al.

NATURE REVIEWS CARDIOLOGY (2017)

Article Genetics & Heredity

JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects

Paul J. Newcombe et al.

GENETIC EPIDEMIOLOGY (2016)

Article Public, Environmental & Occupational Health

Study profile: the Durban Diabetes Study (DDS): a platform for chronic disease research

T. R. Hird et al.

GLOBAL HEALTH EPIDEMIOLOGY AND GENOMICS (2016)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Genetics & Heredity

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Brendan K. Bulik-Sullivan et al.

NATURE GENETICS (2015)

Review Infectious Diseases

Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis

Benjamin J. Visser et al.

MALARIA JOURNAL (2013)

Review Cardiac & Cardiovascular Systems

The Epidemiology of Cardiovascular Diseases in Sub-Saharan Africa: The Global Burden of Diseases, Injuries and Risk Factors 2010 Study

Andrew Moran et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2013)

Article Genetics & Heredity

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies

Buhm Han et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)