期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 808, 期 -, 页码 1-7出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2016.07.008
关键词
Chronic kidney disease; Comet assay; On-line hemodiafiltration; Peripheral blood lymphocytes
资金
- COLCIENCIAS (Departamento Administrativo de Ciencia Tecnologia e Innovation de Colombia)
- Universidad Autonoma de Barcelona (Spain)
- Generalitat de Catalunya (CIRIT) [2014SGR-202]
- Fondo de Investigation Sanitaria (FIS) [PI12/02559]
Chronic kidney disease (CKD) patients exhibit high levels of genetic damage. Part of this genetic damage is supposed to be caused by the hemodialysis (HD) therapy. Different and more efficient HD procedures could reduce the genetic damage and improve health status of CKD patients. In the present study, we analyzed if changing to online hemodiafiltration (OL-HDF) has a beneficial effect on the levels of genetic damage. The levels of genetic damage (DNA breaks and oxidatively damaged DNA) were analyzed in peripheral blood lymphocytes by using the comet assay. Forty-nine patients submitted to HD, 34 of them changing to OL-HDF and 15 patients continuing in low-flux HD, were included in the study. Plasma antioxidant capacity was also determined. Second sampling period was established after 6 months on the new or traditional HD protocol. A slight decrease in the levels of DNA damage was observed in patients who switched to OL-HDF (P=0.048) in relation to the reference group. This reduction is indicative that OL-HDF shows greater efficiency than low-flux HD in the reduction of basal levels of genetic damage. (C) 2016 Elsevier B.V. All rights reserved.
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