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Article
Multidisciplinary Sciences
Jing Lin et al.
Summary: The advantage of oncolytic viruses in cancer therapy lies in their ability to kill tumors directly and induce anti-tumor immune response. This study shows that oncolytic parapoxvirus ovis can trigger tumor cell pyroptosis via GSDME, which plays a critical role in ORFV-based antitumor immunity and sensitizes "cold" tumors to checkpoint blockade.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Qingqing Zhang et al.
Summary: Pyroptosis of tumor cells was induced by biGC@PNA with a precisely stoichiometric ratio of Au(I) ion/Au(0) atom through its radiofrequency (RF)-heating effect. The activated pyroptosis resulted in a robust immunogenic cell death (ICD) effect, enhancing the antitumor immune responses and suppressing tumor metastasis and relapse. The noninvasive RF field provides a promising strategy for improving cancer immunotherapy.
Article
Chemistry, Multidisciplinary
He Wang et al.
Summary: The combination of immunogenic cell death induction in tumors and immune checkpoint blockade therapy has been widely developed to enhance the effectiveness of cancer immunotherapy. This study demonstrates that pyroptosis, a form of immunogenic cell death, is more efficient than apoptosis in activating tumor immunogenicity. By using an epigenetic drug decitabine and photodynamic therapy, the apoptosis-pyroptosis transition can be successfully induced in prostate cancer cells. Furthermore, a nano-drug that can respond to the tumor microenvironment and block PD-L1 is developed for self-synergistic cancer immunotherapy, which shows strong antitumor immune response and long-term immune memory in a poorly immunogenic prostate cancer model.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Binbin Ding et al.
Summary: Researchers discovered that ZIF-8 nanoparticles can induce pyroptosis, a form of cell death, through a caspase-1/gasdermin D (GSDMD)-dependent pathway. This cell death process is accompanied by necrosis and immunogenic cell death (ICD), which triggers an immune response. Furthermore, loading a mitochondrial depolarizing agent, CCCP, into ZIF-8 nanoparticles enhances the pyroptosis process. The modified F127-ZIF-8(CCCP) nanoparticles activate anti-tumor immune response and reshape the tumor microenvironment, leading to effective tumor growth inhibition. This study advances the biomedical applications of ZIF-8 and offers insights into pyroptosis-induced cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lisi Xie et al.
Summary: In this study, phototheranostic metal-phenolic networks were engineered for precise photo thermal therapy. This therapy could relieve exosomal suppression, restore T cells, and enhance ferroptosis. The synergy of photo thermal therapy with antiexosomal PD-L1 evoked potent antitumor immunity and immunological memory against metastatic tumors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A novel porphyrin-based staggered stacking covalent organic framework, COF-618-Cu, is designed to overcome the photobleaching and aggregation-caused quench defects of photosensitizers and the intrinsic antioxidant tumor microenvironment. COF-618-Cu exhibits excellent catalase-like activity and glutathione peroxidase mimic activity, which can alleviate tumor hypoxia by consuming hydrogen peroxide and decrease ROS scavenging by depleting intracellular glutathione. The unique staggered stacking mode of COF-618-Cu effectively relieves both photobleaching and aggregation-caused quench effects. Additionally, COF-618-Cu shows great potential for inducing immunogenic cell death and remodeling the tumor microenvironment to boost antitumor immunity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xingchen Duan et al.
Summary: A novel photoacoustic/photothermal nanoparticle with strong near-infrared absorption, good biocompatibility, and high photothermal conversion efficiency was developed. The nanoparticle shows great potential for improved disease diagnosis and treatment.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhanwei Zhou et al.
Summary: This study developed dimersomes, lipid-like materials capable of depleting glutathione (GSH) in tumors and delivering therapeutic drugs, which enhanced ferroptosis therapy and immunotherapy for breast cancer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Jamie I. Scott et al.
Summary: This study presents a rational design of a fluorogenic peptide that can detect active granzyme B as a biomarker of immune-mediated anticancer action. The probe enables real-time detection of T cell-mediated anticancer activity and has the potential to be used as a biomarker for early response to anticancer treatments.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nina Frey et al.
Summary: This study systematically explores the immune evasion mechanisms of pancreatic ductal adenocarcinoma (PDA) and identifies Vps4b and Rnf31 as essential factors for escaping CD8(+) T cell killing. Inactivation of Vps4b impairs autophagy, leading to increased accumulation of granzyme B derived from CD8(+) T cells and subsequent tumor cell lysis. Inactivation of Rnf31 protects tumor cells from TNF-mediated caspase 8 cleavage and apoptosis induction. Transplantation of Vps4b- or Rnf31-deficient pancreatic tumors into immune competent mice shows increased CD8(+) T cell infiltration and effector function, as well as significantly reduced tumor growth.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Minglun Liu et al.
Summary: The authors report the development of AIEgen-based photosensitizers (PSs) that selectively target the Golgi apparatus, showing enhanced singlet oxygen generation and photodynamic therapy performance in cancer models.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Xia Zhang et al.
Summary: A multiple ROS-based cancer immunotherapy synergistic strategy has been developed in this study to enhance the therapeutic effect of cancer. By embedding copper ions into a three-dimensional covalent organic framework, multifunctional nanomaterial 3D Cu@COF-TATB is prepared. The generated multiple types of ROS can induce immunogenic cell death and activate an immune response to attack the tumor.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Pan Zheng et al.
Summary: Researchers have developed a pyroptosis inducer for cancer immunotherapy by inducing mitochondrial Ca2+ overload. The inducer triggers robust immune responses, effectively suppressing tumor proliferation and lung metastasis, providing new strategies and inspiration for pyroptosis-mediated cancer treatments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Yang Yang et al.
Summary: Phototheranostics based on upconversion nanoparticles can integrate imaging diagnostics and phototherapeutics. This study demonstrates a method to switch from imaging to therapy using upconversion nanoparticles by modulating the irradiation laser, enabling programmable control with minimal side effects. The approach allows for orthogonal activation of in vivo photoacoustic imaging and photodynamic therapy.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Sijia Zhang et al.
Summary: This study explores the combination of regulating tumor glycometabolism with anti-PD-L1 therapy for tumor treatment. By using nanoparticles combined with anti-PD-L1, tumor development is significantly inhibited, increasing the survival time of mice. This strategy also has an immunological memory effect, successfully preventing tumor recurrence and metastasis.
ADVANCED MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Weitong Gao et al.
Summary: Immunotherapy has made significant breakthroughs in cancer treatment, but the poor response of some tumors limits its application. Inducing non-apoptotic regulated cell death (RCD) may convert these unresponsive tumors into those that respond to immunotherapy. Autophagy, ferroptosis, pyroptosis, and necroptosis have been found to have both inhibitory and synergistic effects on antitumor immune responses, suggesting that targeted therapies against these processes combined with immunotherapy may be effective even in resistant tumors.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Chencheng Xue et al.
Summary: A polydopamine-based nanoplatform was developed for efficient loading of Fe2+ and beta-lapachone, which could trigger ferroptosis in tumor cells under near-infrared light. The platform could generate mild hyperthermia under NIR irritation, activate cellular heat shock response, and enhance intracellular H2O2 formation, promoting Fe2+-mediated lipid peroxidation and beta-lapachone release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Min Wu et al.
Summary: Membrane-targeting photosensitizers induced pyroptosis for cancer cell ablation, offering a noninvasive, low side-effect intervention strategy based on photo-activated cell death pathway.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Geoffrey T. Nash et al.
Summary: A new nanoscale metal-organic layer assembly, ZnOPPc@nMOL, has been designed for photodynamic therapy (PDT), which shows exceptional efficacy in inhibiting tumor growth and curing colon cancer in mouse models. The assembly efficiently sensitizes the formation of singlet oxygen by preventing aggregation-induced self-quenching of ZnOPPc excited states. With intrinsic mitochondria-targeting capability, ZnOPPc@nMOL displays strong potential for clinical applications in PDT.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Biotechnology & Applied Microbiology
Xing Liu et al.
Summary: Gasdermins have been identified as mediators of inflammatory cell death known as pyroptosis, forming cell membrane pores upon activation to release pro-inflammatory cytokines. They play important roles in autoimmune and inflammatory diseases, infectious diseases, deafness, and cancer, with potential for novel therapeutic avenues.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Review
Multidisciplinary Sciences
Qingdian Mu et al.
Summary: The article reviews the role of iron in regulating biological processes, immune system development and maintenance, as well as the importance of iron in regulating the inflammatory response and infectious disease processes, the competition between host and pathogen for iron, and the therapeutic implications of targeting iron-related processes for protection against pathogen infection, inflammation control, and improving the efficacy of immunotherapy.
Article
Chemistry, Multidisciplinary
Huan Liang et al.
Summary: This study synthesized ultrasmall single-crystal Fe nanoparticles that showed high activity in inducing tumor cell ferroptosis and immunogenetic cell death in the tumor microenvironment at a low concentration. These nanoparticles effectively suppressed tumor growth, promoted dendritic cell maturation, and triggered T cell response in animal models, and when combined with immune checkpoint blockade therapy, they greatly enhanced the immune response and developed strong immune memory. Furthermore, the nanoparticles were quickly excreted in the kidneys without side effects in normal tissues.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of three-dimensional (3D) covalent organic frameworks (COFs) were designed and synthesized as inducers for immunogenic cell death (ICD) in cancer immunotherapy. These COFs exhibit outstanding ICD-inducing efficiency and one member, COF-609, showed significant therapeutic effects in a mouse model of breast cancer.
Article
Chemistry, Multidisciplinary
Le-Le Zhou et al.
Summary: A nanodrug, RSL3@COF-Fc (2b), based on covalent organic framework (COF) has been fabricated to enhance cellular damage induced by CDT through promoting Fenton-like reactions and inhibiting GPX4 irreversibly. This approach synergistically results in massive lipid peroxide accumulation, subsequent cell damage, and ultimately ferroptosis, not being limited by intracellular glutathione, providing new insights for developing COF-based nanomedicine.
Article
Pharmacology & Pharmacy
Liang Yan et al.
Summary: Triclabendazole induces GSDME-dependent pyroptosis by activating caspase-3, and this process is at least partly through enhancing the ROS/JNK/Bax-mitochondrial apoptotic pathway, leading to significant inhibition of breast cancer cell growth.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: This review focuses on the optical properties of covalent organic frameworks (COFs) and how they correlate with the microscopic structure of COFs. It explores the relationship between key structural factors like connection, orientation, and alignment of molecular building blocks, and the optical properties of COFs. Additionally, the properties of COFs are analyzed from both energy and dynamic aspects to provide insights into the possible underlying mechanisms.
Review
Materials Science, Biomaterials
Qun Guan et al.
Summary: Ferroptosis, a regulated form of cell death caused by lipid peroxidation, has been extensively studied since 2012. Recent research has shown a close relationship between ferroptosis and materials chemistry, particularly nanobiotechnology, and highlighted its potential as an efficient antitumor strategy, especially for apoptosis-resistant tumors.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Multidisciplinary
Yuxuan Xiong et al.
Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.
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