相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources
Gaspar Pandy-Szekeres et al.
NUCLEIC ACIDS RESEARCH (2023)
Cryo-EM structures of orphan GPR21 signaling complexes
Xi Lin et al.
NATURE COMMUNICATIONS (2023)
Structural insight into the constitutive activity of human orphan receptor GPR12
Hao Li et al.
SCIENCE BULLETIN (2023)
Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs
Max E. Huber et al.
CHEMISTRY-A EUROPEAN JOURNAL (2023)
Cryo-EM structure of orphan G protein-coupled receptor GPR21
Thian-Sze Wong et al.
MEDCOMM (2023)
Protein structure predictions to atomic accuracy with AlphaFold
John Jumper et al.
NATURE METHODS (2022)
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Giuseppe Deganutti et al.
NATURE COMMUNICATIONS (2022)
Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120
Siyue Ma et al.
FRONTIERS IN CHEMISTRY (2022)
ColabFold: making protein folding accessible to all
Milot Mirdita et al.
NATURE METHODS (2022)
Ligand recognition and activation of neuromedin U receptor 2
Wenli Zhao et al.
NATURE COMMUNICATIONS (2022)
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Sijie Huang et al.
MOLECULAR CELL (2022)
Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
Amanda E. Wakefield et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)
UCSF ChimeraX: Structure visualization for researchers, educators, and developers
Eric F. Pettersen et al.
PROTEIN SCIENCE (2021)
Highly Selective Y4 Receptor Antagonist Binds in an Allosteric Binding Pocket
Corinna Schuess et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space
Chao Lu et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2021)
Cryo-EM structure of the human MT1-Gi signaling complex
Hiroyuki H. Okamoto et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)
Structural basis of ligand recognition and self-activation of orphan GPR52
Xi Lin et al.
NATURE (2020)
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
Naotaka Tsutsumi et al.
ELIFE (2020)
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist
Takahiro Kawai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions
Shaoyong Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Analysis of tractable allosteric sites in G protein-coupled receptors
Amanda E. Wakefield et al.
SCIENTIFIC REPORTS (2019)
Overexpression of Orphan Receptor GPR61 Increases cAMP Levels upon Forskolin Stimulation in HEK293 Cells: in vitro and in silico Validation of 5-(Nonyloxy)Tryptamine as a Low-Affinity Inverse Agonist
Pawel Kozielewicz et al.
PHARMACOLOGY (2019)
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Dorothee Liebschner et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)
Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments
June Ereno-Orbea et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
Javier Garcia-Nafria et al.
ELIFE (2018)
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Shoji Maeda et al.
NATURE COMMUNICATIONS (2018)
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination
Yi-Lynn Liang et al.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2018)
A comprehensive map of molecular drug targets
Rita Santos et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
Xiangyu Liu et al.
NATURE (2017)
Structural insight into allosteric modulation of protease-activated receptor 2
Robert K. Y. Cheng et al.
NATURE (2017)
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
Ali Punjani et al.
NATURE METHODS (2017)
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
Jun Lu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
Jun Lu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions
Atsuro Oishi et al.
SCIENTIFIC REPORTS (2017)
Structural Basis for G Protein-Coupled Receptor Activation
Aashish Manglik et al.
BIOCHEMISTRY (2017)
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
Janine F. Felix et al.
HUMAN MOLECULAR GENETICS (2016)
Intracellular allosteric antagonism of the CCR9 receptor
Christine Oswald et al.
NATURE (2016)
Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling
Md. Shamim Hossain et al.
PLOS ONE (2016)
Universal allosteric mechanism for Gα activation by GPCRs
Tilman Flock et al.
NATURE (2015)
Two disparate ligand-binding sites in the human P2Y1 receptor
Dandan Zhang et al.
NATURE (2015)
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors
Adam L. Martin et al.
PLOS ONE (2015)
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875
Ankita Srivastava et al.
NATURE (2014)
GPCRDB: an information system for G protein-coupled receptors
Vignir Isberg et al.
NUCLEIC ACIDS RESEARCH (2014)
Allosteric sodium in class A GPCR signaling
Vsevolod Katritch et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
Wei Yuan et al.
NATURE COMMUNICATIONS (2014)
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2013)
Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex
Qiuxiang Tan et al.
SCIENCE (2013)
The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor
Hugo Gutierrez-de-Teran et al.
STRUCTURE (2013)
Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
B. Trzaskowski et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Design, Synthesis, and Pharmacological Evaluation of Piperidin-4-yl amino aryl sulfonamides: Novel, Potent, Selective, Orally Active, and Brain Penetrant 5-HT6 Receptor Antagonists
Ramakrishna Nirogi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
Wei Liu et al.
SCIENCE (2012)
Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors
Eugene Chun et al.
STRUCTURE (2012)
Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor
Hirohide Nambu et al.
LIFE SCIENCES (2011)
Crystal structure of the β2 adrenergic receptor-Gs protein complex
Soren G. F. Rasmussen et al.
NATURE (2011)
The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery
John A. Salon et al.
PHARMACOLOGICAL REVIEWS (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Identification of a sulfonamide series of CCR2 antagonists
Simon Peace et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
The N-Terminal Domain of GPR61, an Orphan G-Protein-Coupled Receptor, Is Essential for Its Constitutive Activity
Masaru Toyooka et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation
Shivani Ahuja et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists
Hamed Aissaoui et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Identification of surrogate ligands, for orphan G protein-coupled receptors
S Takeda et al.
LIFE SCIENCES (2003)
Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin
ECY Yan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain
S Cikos et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2001)
Identification of four novel human G protein-coupled receptors expressed in the brain
DK Lee et al.
MOLECULAR BRAIN RESEARCH (2001)