Atypical primary malignant melanoma originating in the spinal canal: A case report and literature review

Central nervous system (CNS) malignant melanomas are rare tumors of the CNS that are thought to arise from aberrant changes in melanocytes of the neural crest or melanocytic elements of the pia mater during early embryonic development. As a rare type of CNS malignant melanoma, only a few cases of primary malignant melanoma in the spinal canal have been reported thus far. The majority of these studies have reported on the diagnosis, radiographic features and gross total resection of primary spinal canal malignant melanoma; however, the prognosis and ideal treatment of patients with residual tumors remain elusive. The current study presented the rare case of a patient with primary malignant melanoma originating from the thoracic spinal canal, without any history of irradiation exposure and with an incompletely resected tumor. Disease-free survival of >2.5 years was observed in this patient who was treated with concurrent chemoradiotherapy followed by adjuvant chemotherapy with temozolomide and bevacizumab.

Automated summary

CNS malignant melanomas are rare tumors that arise from abnormal changes in melanocytes during embryonic development. Few cases of primary malignant melanoma in the spinal canal have been reported. This study presents a rare case of primary malignant melanoma in the thoracic spinal canal, with an incompletely resected tumor. The patient achieved disease-free survival of over 2.5 years after treatment with chemoradiotherapy and adjuvant chemotherapy.