4.5 Review

Next-Generation Sequencing-Optimal Sequencing of Therapies in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Zanubrutinib in patients with previously treated B-cell malignancies intolerant of previous Bruton tyrosine kinase inhibitors in the USA: a phase 2, open-label, single-arm study

Mazyar Shadman et al.

Summary: The study aimed to evaluate the safety and efficacy of zanubrutinib, a highly selective next-generation Bruton tyrosine kinase (BTK) inhibitor, in patients with previously treated B-cell malignancies who were intolerant of ibrutinib or acalabrutinib. The results suggest that zanubrutinib is a viable treatment option for patients intolerant of previous BTK inhibitors, as it can reduce treatment-related toxicities and discontinuations.

LANCET HAEMATOLOGY (2023)

Article Medicine, General & Internal

Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004) a multicentre, open-label, single-arm, phase 1-2 study & nbsp;

Tanya Siddiqi et al.

Summary: In this study, lisocabtagene maraleucel (liso-cel) was evaluated for its efficacy and safety in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. The results showed that liso-cel induced complete response or remission in patients, including those who had previously failed treatment with a BTK inhibitor and venetoclax. The safety profile was manageable.

LANCET (2023)

Article Medicine, General & Internal

First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia

Barbara Eichhorst et al.

Summary: In fit patients with CLL, venetoclax-obinutuzumab, with or without ibrutinib, showed superior results compared to chemoimmunotherapy as a first-line treatment, with higher rates of undetectable minimal residual disease and progression-free survival.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

Article Multidisciplinary Sciences

Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia

Othman Al-Sawaf et al.

Summary: This study found that patients with previously untreated CLL who received Ven-Obi had significantly better PFS compared to those who received Clb-Obi, and the MRD status at the end of therapy was associated with PFS duration. The results reveal the sustained long-term efficacy of Ven-Obi in treating previously untreated CLL.

NATURE COMMUNICATIONS (2023)

Article Oncology

Single-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study

Lihua E. Budde et al.

Summary: This study evaluated the safety, tolerability, and efficacy of mosunetuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphomas (B-NHLs). The results showed that mosunetuzumab has a manageable safety profile and induces durable complete responses in some patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Hematology

Up to 8-year follow-up from RESONATE-2: first-line ibrutinib treatment for patients with chronic lymphocytic leukemia

Paul M. Barr et al.

Summary: This study reports long-term follow-up data from the RESONATE-2 phase 3 study of ibrutinib in previously untreated CLL patients. The results show that ibrutinib provides sustained benefit in terms of progression-free survival and overall survival, even in patients with high-risk genomic features.

BLOOD ADVANCES (2022)

Article Hematology

Combined ibrutinib and venetoclax for treatment of patients with ibrutinib-resistant or double-refractory chronic lymphocytic leukaemia

Paul J. Hampel et al.

Summary: Patients with disease refractory to commonly used novel agents, such as ibrutinib, may benefit from combined treatment with ibrutinib and venetoclax, as shown in this retrospective study.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Article Hematology

Acalabrutinib Versus Investigator's Choice in Relapsed/Refractory Chronic Lymphocytic Leukemia: Final ASCEND Trial Results

Paolo Ghia et al.

Summary: Acalabrutinib demonstrated superior efficacy and acceptable tolerability in patients with R/R CLL, showing significantly prolonged progression-free survival compared to standard-of-care regimens.

HEMASPHERE (2022)

Article Hematology

Phase II study of acalabrutinib in ibrutinib-intolerant patients with relapsed/refractory chronic lymphocytic leukemia

Kerry A. Rogers et al.

Summary: Acalabrutinib is effective and well tolerated in most patients with relapsed/refractory chronic lymphocytic leukemia who are intolerant to ibrutinib. The majority of patients showed significant efficacy with minimal adverse events, with disease progression being the main reason for intolerance.

HAEMATOLOGICA (2021)

Article Medicine, General & Internal

Dose escalation of subcutaneous epcoritamab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an open-label, phase 1/2 study

Martin Hutchings et al.

Summary: This study aimed to evaluate the safety and recommended dose of a novel bispecific antibody epcoritamab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma. The results showed that the full dose of 48 mg was identified as the recommended phase 2 dose, and no maximum tolerated dose was reached during the treatment. Epcoritamab demonstrated good antitumor activity in some patients during the study.

LANCET (2021)

Article Hematology

Outcomes of patients with CLL sequentially resistant to both BCL2 and BTK inhibition

Thomas E. Lew et al.

Summary: Patients with double class-resistant CLL have a poor prognosis and face high clinical challenges. They are heavily pretreated, enriched for adverse disease genetics, and have a short survival period after second-line TA therapy.

BLOOD ADVANCES (2021)

Article Medicine, General & Internal

Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia

T. D. Shanafelt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

K. Fischer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Venetoclax-Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia

J. F. Seymour et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL

J. A. Woyach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

Andrew W. Roberts et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Mutations driving CLL and their evolution in progression and relapse

Dan A. Landau et al.

NATURE (2015)

Article Medicine, General & Internal

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

Jennifer A. Woyach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia

Richard R. Furman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)