☆ 4.5 Review

Research Progress on Histone Deacetylases Regulating Programmed Cell Death in Atherosclerosis

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2023)

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Article Cell Biology

Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy

Zhenzhen Chen et al.

Summary: Vascular smooth muscle cells (VSMCs) contribute to plaque stability, and their endogenous CTH-H2S is involved in the pathogenesis of plaque stability through activation of TFEB, increasing autophagy, promoting collagen secretion, and inhibiting apoptosis.

AUTOPHAGY (2022)

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Article Pharmacology & Pharmacy

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice

Chuanrui Ma et al.

Summary: This study showed that calycosin protects against atherosclerosis through promoting autophagy, inhibiting foam cell formation, inflammation, and apoptosis. It also identified MLKL as a new autophagy regulator that is negatively regulated by KLF2. Mechanistically, calycosin's inhibitory effects on atherogenesis are mediated through the KLF2-MLKL signaling pathway modulation.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Endocrinology & Metabolism

Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation

Ying Zhao et al.

Summary: The study found that Sirt6 mediates acetylation of Caveolin-1 and inhibits LDL transcytosis under high glucose stimulation through the autophagic degradation mechanism, thus slowing down the progression of atherosclerosis.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

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Review Cell Biology

Modulation of cellular processes by histone and non-histone protein acetylation

Maria Shvedunova et al.

Summary: Lysine acetylation is a crucial protein post-translational modification that plays important roles in cellular and physiological processes. Lysine acetyltransferases and lysine deacetylases regulate gene expression and protein function by controlling acetylation and deacetylation.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Protective effect of liquiritin on coronary heart disease through regulating the proliferation of human vascular smooth muscle cells via upregulation of sirtuin1

Liang Yuan et al.

Summary: This study found that liquiritin plays a protective role in coronary heart disease by regulating the proliferation and migration of hVSMCs through increasing SIRT1 expression.

BIOENGINEERED (2022)

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Review Cell Biology

The Function, Regulation and Mechanism of Programmed Cell Death of Macrophages in Atherosclerosis

Chang Liu et al.

Summary: Atherosclerosis is a chronic inflammatory vascular disease, and macrophages play a significant role in its progression. Recent studies have highlighted the critical role of programmed cell death in macrophages in the development of vulnerable plaques in atherosclerosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Food Science & Technology

5-Heptadecylresorcinol Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice by Modulating SIRT3 Signaling: The Possible Beneficial Effects of Whole Grain Consumption

Yiming Hao et al.

Summary: The biomarker 5-heptadecylresorcinol (AR-C17) has been found to have beneficial effects on reducing serum cholesterol, decreasing atherosclerotic plaques, and improving endothelial cell function. These findings suggest that AR-C17 could be a promising grain-based dietary ingredient for preventing atherosclerosis.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

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Review Cell Biology

Programmed cell death in atherosclerosis and vascular calcification

Min Li et al.

Summary: The concept of cell death has expanded to include various forms such as necroptosis, pyroptosis, autophagy, and ferroptosis, in addition to apoptosis and necrosis. These different modes of cell death play critical roles in all aspects of life and have diverse implications in diseases. Atherosclerosis (AS) and vascular calcification (VC) are major causes of high morbidity and mortality in cardiovascular disease. Despite advancements in understanding the signaling pathways associated with AS and VC, the exact molecular basis remains unknown. This article reviews the molecular mechanisms underlying cell death and its implications for AS and VC, which may lead to the development of promising therapeutic strategies.

CELL DEATH & DISEASE (2022)

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Review Immunology

Ferroptosis and Autoimmune Diseases

Benjamin Lai et al.

Summary: This review discusses the role and mechanisms of ferroptosis in autoimmune diseases and explores the potential of targeting ferroptosis as a therapeutic approach for these diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Role of Histone Post-Translational Modifications in Inflammatory Diseases

Yingying Lin et al.

Summary: Inflammation is a defensive reaction to external stimuli in the human body and is associated with various diseases. Histone modifications play a significant role in the regulation of inflammation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2

Fei Fu et al.

Summary: The study demonstrates that Ruscogenin can exert cardioprotective effects by activating the Keap1/Nrf2/HO-1 pathway and through BCAT1/BCAT2, alleviating ferroptosis induced by MI.

ANTIOXIDANTS (2022)

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Article Cell Biology

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Feng Yao et al.

Summary: This study found that HDAC11 is involved in endothelial cell pyroptosis in atherosclerosis (AS). TNF-α induces pyroptosis in HUVECs through TNFR1-mediated upregulation of HDAC11. Knockdown of HDAC11 suppresses pyroptosis in TNF-α-induced HUVECs by inhibiting both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways. Furthermore, HDAC11 affects pyroptosis by regulating the acetylation levels of ERG.

CELL DEATH DISCOVERY (2022)

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Article Immunology

Sirt6 inhibits vascular endothelial cell pyroptosis by regulation of the Lin28b/let-7 pathway in atherosclerosis

Feng Yao et al.

Summary: This study found that Sirt6 inhibits vascular endothelial cell pyroptosis in atherosclerosis (AS) by negatively regulating the Lin28b/let-7 pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Immunology

Role of pyroptosis in inflammation and cancer

Xiang Wei et al.

Summary: This article reviews the mechanisms, newly discovered influencing factors, anti-tumoral properties, and applications of pyroptosis in various diseases. Moreover, it provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and addresses the challenges and future directions in the field.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation

Shu Song et al.

Summary: The study showed that reduced expression of SIRT3 in diabetic cardiomyopathy worsens cardiac dysfunction, myocardial injury, ROS accumulation, necroptosis, and inflammation, ultimately exacerbating the condition. This suggests SIRT3 could be a potential molecular target for preventing and treating diabetic cardiomyopathy.

ACTA PHARMACOLOGICA SINICA (2021)

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Review Cardiac & Cardiovascular Systems

Iron and cardiovascular diseases

Yoshiro Naito et al.

Summary: The research reveals an iron paradox in cardiovascular diseases: iron deficiency is associated with heart failure, while iron overload is linked to atherosclerosis. Iron metabolism plays a crucial role in cardiovascular diseases, but the regulatory mechanisms remain unclear.

JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway

Shuang Xu et al.

Summary: This study found that nicotine induces macrophage pyroptosis in atherosclerosis through the HDAC6/NF-kappa B/NLRP3 signaling pathway. These results suggest that nicotine promotes macrophage pyroptosis via this signaling pathway, which may contribute to a better understanding of the mechanisms of nicotine in atherosclerosis.

ATHEROSCLEROSIS (2021)

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Article Plant Sciences

Polydatin alleviates high-fat diet induced atherosclerosis in apolipoprotein E-deficient mice by autophagic restoration

Qingping Xiong et al.

Summary: The study found that polydatin alleviates atherosclerotic lesions through autophagic restoration, inhibits the expression of PI3K/Akt/mTOR pathway proteins, indicating its potential role in improving atherosclerosis.

PHYTOMEDICINE (2021)

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Article Medicine, Research & Experimental

HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2

Hao Wang et al.

Summary: The study showed that miR-224-3p reduces endothelial cell apoptosis, inflammatory responses, and ROS levels by targeting FOSL2, while HIF1 alpha promotes endothelial cell apoptosis and ROS accumulation. HDAC1 inhibits HIF1 alpha expression through deacetylation, enhancing the inhibitory effect of miR-224-3p and reducing endothelial cell apoptosis and ROS accumulation.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Biochemistry & Molecular Biology

Oxidative Stress Triggers Defective Autophagy in Endothelial Cells: Role in Atherothrombosis Development

Cristina Carresi et al.

Summary: Atherothrombosis, a complex artery disorder, is a major cause of morbidity and mortality worldwide. Imbalance between oxidative stress and antioxidant defenses triggers cellular events leading to vascular wall remodeling and thrombus formation. Emerging studies focus on clotting activation and defective autophagy as potential therapeutic targets for atherosclerotic disease.

ANTIOXIDANTS (2021)

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Review Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot et al.

Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U)

Peipei Ge et al.

Summary: miR-512-3p regulates the survival and migration of ox-LDL-treated endothelial cells by modulating XBP-1, playing a role in preventing and alleviating atherosclerosis.

BIOENGINEERED (2021)

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Article Biochemistry & Molecular Biology

Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission

Yu Xu et al.

Summary: CD137 signaling induces macrophage apoptosis by promoting mitochondrial fission dependent on the p38 MAPK pathway.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Advanced research on the regulated necrosis mechanism in myocardial ischemia-reperfusion injury

Jianying Deng

Summary: Myocardial ischemia-reperfusion injury is a critical factor affecting the prognosis of myocardial infarction patients, leading to various adverse effects. Regulated necrosis, a newly discovered type of cell death, plays an important role in cardiovascular diseases.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Medicine, Research & Experimental

MicroRNA-146a-3p/HDAC1/KLF5/IKBα signal axis modulates plaque formation of atherosclerosis mice

Huajin Liu et al.

Summary: The study investigated the role of miR-146a-3p and HDAC1 in plaque formation in AS mice, indicating increased miR-146a-3p and KLF5 levels, and decreased HDAC1 and IKB alpha levels in aortic wall tissues. Depletion of miR-146a-3p or restoration of HDAC1 led to improved stability of pathological plaques and reduced inflammatory factors in AS mice.

LIFE SCIENCES (2021)

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Editorial Material Endocrinology & Metabolism

RIPK1 targeting protects against obesity and atherosclerosis

Yahya Sohrabi et al.

Summary: Unhealthy lifestyles and dietary habits can lead to diet-associated inflammatory diseases like obesity and atherosclerosis. Recent studies suggest that silencing RIPK1 can reduce diet-induced obesity, NAFLD, and atherosclerosis by reducing inflammation, lipid synthesis, and inflammasome activation, potentially offering therapeutic benefits for chronic metabolic diseases.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Review Cell Biology

Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis

Jing Xu et al.

Summary: Atherosclerosis is the leading cause of mortality in metabolic-related diseases, with characteristics of MetS potentially activating multiple mechanisms that increase the risk of developing atherosclerosis and T2DM. Impaired autophagy induced by MetS is linked to oxidative stress, inflammation, and foam cell formation, further promoting atherosclerosis. Autophagic homeostasis is crucial for the development and outcome of atherosclerosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1B and IL-18

Guangming Su et al.

Summary: Ferroptosis is associated with atherosclerosis, and activation of SIRT1 can inhibit ferroptosis and IL-1(3 and IL-18 levels in foam cells, providing a novel therapeutic target for AS.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Medicine, Research & Experimental

Oxymatrine attenuates oxidized low-density lipoprotein-induced HUVEC injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway

Xin Jin et al.

Summary: Oxymatrine attenuates ox-LDL-induced human umbilical vein endothelial cell injury by inhibiting NLRP3 inflammasome-mediated pyroptosis through activating the SIRT1/Nrf2 signaling pathway.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Pharmacology & Pharmacy

Pyroptosis in the Initiation and Progression of Atherosclerosis

Zhengtao Qian et al.

Summary: Pyroptosis, a newly discovered form of programmed cell death, was initially found to facilitate host defense against pathogenic microorganisms, but later studies revealed its important role in inflammatory immune diseases and tumor resistance. Recent research has linked pyroptosis to the initiation, progression, and complications of atherosclerosis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biology

CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis

Xiaohao Zhang et al.

Summary: This study found that circRSF1 regulates ox-LDL-induced vascular endothelial cell proliferation, apoptosis, and inflammation through modulating the miR-135b-5p/HDAC1 axis in AS, offering new perspectives and methods for AS treatment and diagnosis.

BIOLOGICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway

Jinna Chen et al.

Summary: Low shear stress induces vascular endothelial cell pyroptosis through the TET2/SDHB/ROS pathway, offering new insights into atherosclerosis. TET2 deficiency results in upregulation of SDHB expression and activity, leading to increased ROS production and mitochondrial injury.ROS scavenger NAC can alleviate VEC pyroptosis induced by SDHB overexpression and TET2 deficiency.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Medicine, Research & Experimental

Ferroptosis as a novel therapeutic target for cardiovascular disease

Xiaoguang Wu et al.

Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.

THERANOSTICS (2021)

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Article Cardiac & Cardiovascular Systems

p53-Dependent LincRNA-p21 Protects Against Proliferation and Anti-apoptosis of Vascular Smooth Muscle Cells in Atherosclerosis by Upregulating SIRT7 via MicroRNA-17-5p

Haojie Wang et al.

Summary: This study found that p53-lincRNA-p21 inhibits the progression of AS by downregulating miR-17-5p and increasing the expression of SIRT7, thereby promoting apoptosis and reducing proliferation of VSMCs to decrease vulnerable plaque formation.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2021)

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Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells

Tingting Wang et al.

BIOCHEMISTRY AND CELL BIOLOGY (2020)

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Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages

Lin Xiao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)

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Autophagy as a novel therapeutic target in vascular calcification

Kanchan Phadwal et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Yun Luo et al.

Aging-US (2020)

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Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis

Sarah Colijn et al.

DISEASE MODELS & MECHANISMS (2020)

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Laminar flow inhibits the Hippo/YAP pathway via autophagy and SIRT1-mediated deacetylation against atherosclerosis

Ping Yuan et al.

CELL DEATH & DISEASE (2020)

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Rosuvastatin protects against endothelial cell apoptosisin vitroand alleviates atherosclerosis in ApoE(-/-)mice by suppressing endoplasmic reticulum stress

Jianan Geng et al.

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The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas

Seyeon Oh et al.

MARINE DRUGS (2020)

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Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Mark S. D'Arcy

CELL BIOLOGY INTERNATIONAL (2019)

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Tao Xu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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The Biological Effects of Interleukin-17A on Adhesion Molecules Expression and Foam Cell Formation in Atherosclerotic Lesions

Shohei Shiotsugu et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2019)

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Effect of Autophagy Regulated by Sirt1/FoxO1 Pathway on the Release of Factors Promoting Thrombosis from Vascular Endothelial Cells

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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MicroRNA-217 is involved in the progression of atherosclerosis through regulating inflammatory responses by targeting sirtuin 1

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Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

Yan Dong et al.

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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

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Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice

Yuan-yuan Kong et al.

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NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

Zahra Hoseini et al.

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Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

Yusuke Osonoi et al.

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SIRT2 decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by modulating macrophage polarization

BuChun Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis

Mandy O. J. Grootaert et al.

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Celosins inhibit atherosclerosis in ApoE-/- mice and promote autophagy flow

Ying Tang et al.

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Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

Xianxian Wu et al.

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GLP-1 treatment protects endothelial cells from oxidative stress-induced autophagy and endothelial dysfunction

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Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition

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Mild hypothermia protects hippocampal neurons against oxygen-glucose deprivation/reperfusion-induced injury by improving lysosomal function and autophagic flux

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Article Multidisciplinary Sciences

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

S Imai et al.

NATURE (2000)

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