☆ 4.7 Review

Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications

CELL DEATH & DISEASE (2023)

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Article Oncology

Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

Julie R. Brahmer et al.

Summary: This study aimed to evaluate the safety and tolerability of anti-PD-1 therapy in patients with treatment-refractory solid tumors and to assess its antitumor activity, pharmacodynamics, and immunologic correlates. The results showed that anti-PD-1 therapy was well tolerated and resulted in partial or complete responses in some patients. Based on these findings, it is suggested that combination therapies with other drugs may further enhance the treatment efficacy.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Oncology

A multicenter phase 2 single arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pre-treated with one immune-checkpoint inhibitor: The BREAKPOINT trial (Meet-Uro trial 03)

Giuseppe Procopio et al.

Summary: The study demonstrates that cabozantinib as second-line therapy after immune-checkpoint inhibitors is effective in mRCC patients and can prolong survival. Additionally, the safety profile of the drug can be managed.

TUMORI JOURNAL (2023)

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Article Oncology

Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapy

Xiashuang Zhao et al.

Summary: This study comprehensively examined the expression and prognostic value of ICOS in 33 different cancers using bioinformatics techniques. The findings showed that ICOS expression was up-regulated in most cancer types and it was highly expressed in gastric, breast, liver and renal cell carcinoma cell lines. The high expression of ICOS was associated with poor prognosis in melanoma and glioma, while strong ICOS expression was associated with better prognosis in ovarian cancer, sarcoma, skin cutaneous melanoma, thymoma, uterine corpus endometrial carcinoma, and head and neck squamous cell carcinoma.

BMC CANCER (2023)

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Article Cell Biology

Blocking of programmed cell death-ligand 1 (PD-L1) expressed on endothelial cells promoted the recruitment of CD8+IFN-γ+ T cells in atherosclerosis

Qi Li et al.

Summary: Blocking of PD-L1 promotes CD8+IFN-gamma+ T cell-mediated immune responses, exacerbating inflammation and increasing the burden of atherosclerosis under high-cholesterol diet. However, further studies are needed to explore whether PD-L1 activation could be a novel immunotherapy strategy for atherosclerosis.

INFLAMMATION RESEARCH (2023)

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Review Cardiac & Cardiovascular Systems

Vascular endothelial cell development and diversity

Emily Trimm et al.

Summary: Vascular endothelial cells play a crucial role in the circulatory system and have been extensively studied in recent years using single-cell genomics and in vivo genetic labelling techniques. These studies have provided new insights into endothelial cell development, plasticity, and heterogeneity, as well as their interactions with other cell types. The findings have important implications for vascular medicine, and the use of advanced techniques like single-cell multimodal omics has further enhanced our understanding of normal vascular physiology and disease perturbations.

NATURE REVIEWS CARDIOLOGY (2023)

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Article Biochemistry & Molecular Biology

Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial

Nabil F. Saba et al.

Summary: PD-1 therapy is standard treatment for recurrent metastatic head and neck squamous cell carcinoma. The combination of Pembrolizumab and Cabozantinib shows promising clinical activity. Further research is needed.

NATURE MEDICINE (2023)

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Article Peripheral Vascular Disease

Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma

Ngar Woon Kam et al.

Summary: Different functions and profiles of B-cell subsets in various cancers have been reported. In esophageal squamous cell carcinoma (ESCC), proliferating B cells are predominantly found in the peritumoral region with high expression of HMGB1. Cancer-derived HMGB1 modulates B cells to promote angiogenesis in ESCC microenvironment.

ANGIOGENESIS (2022)

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Review Immunology

B Cell Function in the Tumor Microenvironment

Stephanie M. Downs-Canner et al.

Summary: The tumor microenvironment (TME) is a complex organization composed of tumor, stroma, and endothelial cells that interact with immune cells to control tumor growth. While the role of T lymphocytes in this process is well characterized, the function of B lymphocytes is less understood. However, there are various populations of B cells in the TME that contribute to the immune response to cancer.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Directing CAR T cells towards the tumor vasculature for the treatment of solid tumors

Parvin Akbari et al.

Summary: In this review, recent advances in CAR T cell therapy against solid tumors, with a focus on targeting the tumor vasculature, are discussed. Opportunities to overcome challenges and barriers through engineering of CAR T cells to enhance trafficking, safety, and efficacy are also explored.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

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Article Oncology

Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

Assia Asrir et al.

Summary: Tumor-associated high endothelial venules (TA-HEVs) are crucial for recruiting lymphocytes into tumors, and their presence is associated with better response and survival in anti-PD-1/anti-CTLA-4 treatment. TA-HECs co-express specific proteins and selectins, which attract lymphocytes to infiltrate tumors. Understanding the mechanism of lymphocyte trafficking in cancer immunity and immunotherapy is important for improving treatment outcomes.

CANCER CELL (2022)

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Article Oncology

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

Julia Femel et al.

Summary: Galectin-1 (Gal1) is a glycan-binding protein that promotes tumor progression through various mechanisms. Vaccination against Gal1 can generate high anti-Gal1 antibody levels and significantly impairs the growth of Gal1-expressing melanomas in mice. This is associated with improved tumor vasculature perfusion and increased infiltration of macrophages and cytotoxic T cells. Gal1 vaccination is a promising approach to enhance immunotherapeutic strategies for cancer therapy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

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Review Oncology

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Nisha Kumari et al.

Summary: Cancer immunotherapy has had limited success, but nanoparticles have emerged as crucial tools in targeting tumor-associated macrophages (TAMs) and improving therapy outcomes. Current strategies include restricting TAMs survival, inhibiting TAMs recruitment, and repolarizing tumor-supportive TAMs to an antitumor phenotype.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Oncology

Immune-checkpoint inhibitors: long-term implications of toxicity

Douglas B. Johnson et al.

Summary: Immune-checkpoint inhibitors have improved outcomes for advanced-stage solid tumour patients, but they also carry the risk of chronic toxicities that can affect patients' quality of life. While evidence on chronic toxicities is limited, emerging evidence suggests that they may be more common than previously thought. These toxicities can affect various organ systems and may even lead to fatal outcomes. Research on the effects of immune-checkpoint blockade on other immune processes is also important for cancer survivors.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Pharmacology & Pharmacy

NOX1 and NOX2: Two enzymes that promote endothelial-to-mesenchymal transition induced by melanoma conditioned media

Valentin Platel et al.

Summary: The tumor microenvironment is important for the progression of melanoma, and recent studies have found that endothelial cells (EC) play a role in the endothelial-to-mesenchymal transition (EndMT). Reactive oxygen species (ROS), primarily produced by NAPDH oxidases (NOX), can control tumor growth. This study aimed to investigate the role of NOX1 and NOX2 in EndMT induced by conditioned media (CM) from melanoma cells. The results showed that NOX1 and NOX2 played important roles in EndMT.

PHARMACOLOGICAL RESEARCH (2022)

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Article Multidisciplinary Sciences

Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation

Qiang Zhao et al.

Summary: In the bone marrow, dendritic cell development is regulated by endothelial cells. The expression of serine/threonine kinase 11 in endothelial cells impacts the differentiation of dendritic cell precursors by modulating the secretion of stem cell factor. Mutations in the tumor suppressor liver kinase b1 gene in endothelial cells disrupt the differentiation of dendritic cell precursors, leading to a reduction in mature dendritic cell numbers and the development of tumors.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Molecular Characteristics, Clinical Significance, and Cancer Immune Interactions of Angiogenesis-Associated Genes in Gastric Cancer

Xin Qing et al.

Summary: This study systematically assessed the association between angiogenesis and gastric cancer (GC). The authors identified two molecular subtypes and determined the correlation between angiogenesis-associated genes mutations, clinicopathological characteristics, prognosis, immune cell infiltration, and tumor microenvironment. They established an AAG_score for predicting overall survival (OS) and created a reliable nomogram for clinical viability. The study provides insights into the characteristics of TME and potential immunotherapy strategies in GC.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Targeting TNFR2 in Cancer: All Roads Lead to Rome

Jingchao Bai et al.

Summary: TNF receptor 2 (TNFR2) has emerged as a promising immune checkpoint target in cancer treatment due to its crucial role in tumor microenvironments. Blocking or activating TNFR2 may offer potential therapeutic strategies, with evidence suggesting that TNFR2 activation can also inhibit tumor progression.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Tumor endothelial cell-induced CD8+ T-cell exhaustion via GPNMB in hepatocellular carcinoma

Yoshihiro Sakano et al.

Summary: The role of tumor endothelial cells (TECs) in tumor-infiltrating T cells in hepatocellular carcinoma (HCC) is still unknown. This study found that TECs induce T cell exhaustion in HCC via expression of glycoprotein nonmetastatic melanoma protein B (GPNMB), suggesting GPNMB as a potential therapeutic target in HCC.

CANCER SCIENCE (2022)

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Review Cell Biology

Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons

Adel Naimi et al.

Summary: The discovery of immune checkpoint proteins led to the development of immune checkpoint inhibitors (ICIs), a promising approach in tumor immunotherapy. However, resistance and treatment-related toxicities remain challenges in the clinical application of ICIs.

CELL COMMUNICATION AND SIGNALING (2022)

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Article Oncology

Bevacizumab Plus Atezolizumab After Progression on Atezolizumab Monotherapy in Pretreated Patients With NSCLC: An Open-Label, Two-Stage, Phase 2 Trial

Jiyun Lee et al.

Summary: The combination of bevacizumab and atezolizumab in patients with metastatic NSCLC who experienced disease progression after atezolizumab monotherapy showed promising antitumor activity with good tolerability.

JOURNAL OF THORACIC ONCOLOGY (2022)

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Article Oncology

The impact of VEGF on cancer metastasis and systemic disease

Yunlong Yang et al.

Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Cell Biology

The Role of MiR-181 Family Members in Endothelial Cell Dysfunction and Tumor Angiogenesis

Chun Yang et al.

Summary: Endothelial dysfunction is crucial in angiogenesis-related diseases, and the miR-181 family plays a significant role in regulating angiogenesis. Understanding the functional mechanisms of miR-181 family members is valuable for developing therapeutics for angiogenesis-related diseases.

CELLS (2022)

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Article Cell Biology

Endothelial extracellular vesicles promote tumour growth by tumour-associated macrophage reprogramming

Makon-Sebastien Njock et al.

Summary: This study found that endothelial cell-derived extracellular vesicles (EVs) participate in the recruitment of macrophages within the tumour in the tumour microenvironment, leading to a change in the immunomodulatory phenotype and promoting tumour growth.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Immunology

The role of CCL2, CCL7, ICAM-1, and VCAM-1 in interaction of endothelial cells and natural killer cells

Hye Won Jun et al.

Summary: This study examined the role of endothelial cells in the homing of natural killer (NK) cells to solid tumors. It was found that TNF-α and IL-1β activated endothelial cells, which increased NK cell migration and adhesion to the endothelial cells through the production of CCL2 and CCL7, as well as the upregulation of ICAM-1 and VCAM-1 expression on the endothelial cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy

Peace Mabeta et al.

Summary: The VEGF/VEGFR axis plays a crucial role in angiogenesis and tumor vascularization. Current therapies targeting VEGF and its receptors have shown limited effectiveness and undesirable off-target effects. Recent studies have identified VEGF splice variants that modulate angiogenesis, and their expression is regulated by cues within the tumor microenvironment. These variants challenge the established norm of VEGF signaling and their aberrant expression has been observed in several cancers, highlighting the need for further research on their role in cancer and their impact on antiangiogenic therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Simona Caruso et al.

Summary: The study demonstrates the potential of using off-the-shelf CAR.CD123-NK cells as a therapeutic strategy for paediatric AML patients, showing significant anti-leukaemia activity and improved safety compared to CAR.CD123-T cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Cell Biology

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

Ilaria Elia et al.

Summary: This study reveals the mechanism by which tumor-derived lactate in the tumor microenvironment inhibits the cytotoxicity of CD8(+) T cells, highlighting the role of metabolic pathways in regulating T cell cytotoxicity.

CELL METABOLISM (2022)

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Article Biochemistry & Molecular Biology

Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

Andrew X. Zhu et al.

Summary: This study analyzed tumor samples from patients with hepatocellular carcinoma and found that combination therapy with atezolizumab and bevacizumab was effective in treating this type of cancer. Patients with high expression of VEGF Receptor 2, regulatory T cells, and myeloid inflammation signatures showed better outcomes with the combination therapy compared to atezolizumab alone. These findings provide insights into baseline immune and genetic features that can identify patients who will benefit from the combination therapy of atezolizumab and bevacizumab in advanced hepatocellular carcinoma.

NATURE MEDICINE (2022)

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Review Cell Biology

Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation

Katharina E. M. Hellenthal et al.

Summary: The loss of endothelial barrier function during systemic inflammation is a key contributor to organ dysfunction and mortality. Endothelial cells play a critical role in maintaining organ integrity and regulating tissue perfusion. Inflammatory stimuli can activate endothelial cells, leading to a loss of endothelial barrier function and the development of tissue edema and hypotension, which are lethal outcomes.

CELLS (2022)

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Review Pharmacology & Pharmacy

Targeting endothelial cell metabolism in cancerous microenvironment: a new approach for anti-angiogenic therapy

Parisa Mohammadi et al.

Summary: Anti-angiogenic therapy is an effective method for managing diseases with increased angiogenesis, but the current therapies are not efficient enough. Therefore, researchers are interested in exploring novel therapeutic strategies that target metabolic pathways.

DRUG METABOLISM REVIEWS (2022)

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Review Biochemistry & Molecular Biology

Tumor buster-where will the CAR-T cell therapy 'missile' go?

Chunrun Qu et al.

Summary: Chimeric antigen receptor (CAR) T cell therapy based on gene editing technology is a significant breakthrough in personalized immunotherapy for human cancer. It enables T cells to target tumor-specific antigens and attack cancer cells, bypassing tumor cell apoptosis avoidance mechanisms to some extent. However, tumor antigen escape, treatment-related toxicity, and the immunosuppressive tumor microenvironment limit its effectiveness in solid tumor treatment.

MOLECULAR CANCER (2022)

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Article Nanoscience & Nanotechnology

Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration

Kaiting Yang et al.

Summary: Researchers have developed a metal-based polymeric nanoparticle that delivers STING agonists to tumors, disrupting endothelial cells in the tumor vasculature and targeting tumor-associated macrophages to elicit an anti-tumor immune response in hard-to-treat cancer models.

NATURE NANOTECHNOLOGY (2022)

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Review Immunology

Interferon-γ: teammate or opponent in the tumour microenvironment?

Angela M. Gocher et al.

Summary: IFN gamma plays pleiotropic roles in the tumor microenvironment, acting as both a 'teammate' to promote antitumor immune responses and an 'opponent' promoting tumor growth and suppressing immune responses.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Pharmacology & Pharmacy

Endothelial cell and T-cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation

Michelangelo Certo et al.

Summary: The role of metabolic reprogramming in coordinating the immune response has been increasingly recognized, with T cells and endothelial cells both undergoing metabolic adjustments to meet the energy demands during inflammation and modulate the function of immune cells. Recent insights in this complex crosstalk between endothelial cells and T cells following activation highlight key components of metabolic switch for potential development of new therapeutics against chronic inflammatory disorders.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment

Chenfei Zhou et al.

Summary: The high levels of miR-142-5p in advanced CSCC positively correlate with IDO expression in tumor-associated lymphatic vessels. The miR-142-5p is transferred by CSCC-secreted exosomes into LECs to induce IDO expression via ARID2-DNMT1-IFN-gamma signaling, leading to CD8(+)T cell exhaustion. This study suggests that LECs play a crucial role as immune checkpoints in the TME and may be a potential new target for CSCC diagnosis and treatment.

CELL DEATH AND DIFFERENTIATION (2021)

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Review Oncology

B7-H3: An Attractive Target for Antibody-based Immunotherapy

Filippos Kontos et al.

Summary: B7-H3, as a potential target for antibody-based immunotherapy, is overexpressed in malignant tissues and associated with poor prognosis. Although the receptor for B7-H3 remains unknown, various antibody-based strategies targeting B7-H3-expressing cancer cells have been developed, demonstrating potent antitumor activity in preclinical models. Ongoing clinical trials are evaluating the safety and efficacy of these strategies in patients, with the hope of enhancing the therapeutic efficacy of tumor immunity.

CLINICAL CANCER RESEARCH (2021)

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Review Pharmacology & Pharmacy

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint

TingTing Tang et al.

Summary: The CD40 receptor and its ligand CD40L play a critical role in immune activation, with various therapeutic agents targeting this interaction showing promising clinical efficacy in treating malignancies and autoimmune diseases. The signaling pathways activated by CD40/CD40L interaction lead to immune cell activation and modulation, making it an attractive target for immunotherapy. Ongoing and completed clinical trials have demonstrated the potential of CD40/CD40L-targeted therapy in activating immune responses and treating diseases.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Cell Biology

KRAS G12V mutation upregulates PD-L1 expression via TGF-β/EMT signaling pathway in human non-small-cell lung cancer

Li-Na Pan et al.

Summary: This study demonstrates that KRAS G12V mutation could induce PD-L1 expression and promote immune escape via the transforming growth factor-beta/EMT signaling pathway in KRAS-mutant NSCLC, providing a potential therapeutic approach for NSCLC harboring KRAS mutations.

CELL BIOLOGY INTERNATIONAL (2021)

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Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Immunology

TIM-3: An update on immunotherapy

Lizhen Zhao et al.

Summary: TIM-3, originally found on Th1 cells, has been discovered to be expressed on various immune cells with different ligands and effects. It plays a significant role in autoimmune diseases, chronic viral infections and tumors. Targeting TIM-3 is a promising approach in current immunotherapy, especially in combination with other immune checkpoint blockers.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mouse Breast Carcinoma Monocytic/Macrophagic Myeloid-Derived Suppressor Cell Infiltration as a Consequence of Endothelial Dysfunction in Shb-Deficient Endothelial Cells Increases Tumor Lung Metastasis

Qi He et al.

Summary: The passage discusses the intricate interplay between tumor cells, tumor stroma, and immune response, particularly focusing on the role of vascular barrier properties and the impact of Shb gene deletion on lung metastasis. It was found that Shb deficiency in EC promotes the recruitment of immune cells, leading to enhanced lung metastasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

CD137+ T-Cells: Protagonists of the Immunotherapy Revolution

Alessio Ugolini et al.

Summary: The CD137 receptor, expressed by activated antigen-specific T-cells, plays a crucial role in driving immune responses against cancer. CD137(+) T-cells, capable of recognizing a wide range of tumor-derived peptides, have shown efficacy in killing cancer cells both in vitro and in vivo, making them a promising candidate for immunotherapy strategies. CD137-targeting monoclonal antibodies have demonstrated antitumor efficacy in cancer patients, with ongoing clinical trials to explore their potential in combination approaches of immunotherapy. Additionally, the intracellular domain of the CD137 receptor has been incorporated into anti-CD19 CAR-T cells approved for treating pediatric B-cell leukemia and refractory B-cell lymphoma.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation

Jeremie Joffre et al.

Summary: Endothelial cells undergo phenotypic and functional modifications during sepsis and acute inflammation, leading to microvascular dysfunction and multiorgan failure, with oxidative stress playing a crucial role. Future research directions include understanding the role of oxidative stress in endothelial cells and targeting the therapeutic potential and issues in sepsis and septic shock.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Letter Biochemistry & Molecular Biology

Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy

Chi Yan et al.

MOLECULAR CANCER (2021)

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Article Biotechnology & Applied Microbiology

M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2

Yuhan Yang et al.

Summary: The study revealed that exosomes derived from M2 macrophages can promote angiogenesis in PDAC, leading to accelerated tumor growth. By transferring miR-155-5p and miR-221-5p to endothelial cells, the interaction between TAMs and angiogenesis in PDAC was further confirmed. Targeting exosomal miRNAs from TAMs may provide diagnostic and therapeutic strategies for PDAC.

MOLECULAR THERAPY (2021)

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Article Biochemistry & Molecular Biology

STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

Ying Shen et al.

Summary: The study demonstrates the crucial role of YAP/TAZ in endothelial cells during tumor angiogenesis. Inhibition of YAP/TAZ reduces vessel density and tumor progression, while STAT3 is necessary for their activation in tumor-associated endothelial cells.

SCIENCE SIGNALING (2021)

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Article Multidisciplinary Sciences

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

Riyao Yang et al.

Summary: The study reveals that PD-1 contributes to exhausted T cell survival by binding to TIM-3 ligand Gal-9 and inhibiting Gal-9/TIM-3 induced cell death. Anti-Gal-9 therapy selectively expands intratumoral TIM-3(+) cytotoxic CD8 T cells and T-reg cells, while combination treatment with anti-Gal-9 and GITR agonist shows synergistic antitumor activity.

NATURE COMMUNICATIONS (2021)

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Review Peripheral Vascular Disease

Vascular endothelial cell specification in health and disease

Corina Marziano et al.

Summary: There are two vascular networks in mammals which play integral roles in the body's supply and drainage systems. These networks consist of arteries, veins, capillaries, and lymphatic vessels with specialized functions. Endothelial cells, the main components of these vessels, have specific identities that contribute to their physiological functions and responses to circulating factors. Dysregulation of these processes can lead to vascular malformations, and various therapeutic approaches have been developed for their treatment.

ANGIOGENESIS (2021)

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Review Biochemistry & Molecular Biology

Anti-Angiogenic Therapy: Current Challenges and Future Perspectives

Filipa Lopes-Coelho et al.

Summary: Anti-angiogenic therapy aims to fight cancer by disrupting the nutrient and oxygen supply to tumor cells, mainly by targeting vascular endothelial growth factor (VEGF). While some drugs in this category can enhance immune therapy, they often fall short in terms of efficacy. Researchers believe that targeting alternative angiogenic pathways in combination could be a promising solution.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

Camille L. Duran et al.

Summary: Metastasis is a major cause of cancer deaths, and targeting the Tie2 receptor in the tumor microenvironment may be an effective anti-metastatic therapy.

CANCERS (2021)

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Article Oncology

Anti-angiogenic agents - overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

Zowi R. Huinen et al.

Summary: Anti-angiogenic therapy has the potential to enhance antitumor immunity by inhibiting immunosuppressive features of angiogenesis. Combinations of anti-angiogenic agents and immunotherapy have shown success in clinical trials and have been approved by the FDA. The article discusses the impact of angiogenesis on antitumor immunity, the role of endothelial cells, and the progress in combining anti-angiogenic agents with immune checkpoint inhibitors.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Oncology

Therapeutic Targeting of the Tumor Microenvironment

Leire Bejarano et al.

Summary: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.

CANCER DISCOVERY (2021)

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Article Oncology

MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions AC

Anastasia O. Gkountidi et al.

Summary: This study demonstrates that tumoral lymphatic endothelial cells (LEC) can promote tumor growth by upregulating MHC class II and antigen-processing machinery, leading to Treg expansion and suppression of effector T-cell infiltration. Lack of MHC class II expression in LECs impairs tumor growth, increases effector T-cell infiltration, and alters Treg-suppressive functions. Antigen presentation by LECs locally in the tumor microenvironment is crucial for promoting Treg-mediated immunosuppression.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Oncology

Bifunctional iRGD-anti-CD3 enhances antitumor potency of T cells by facilitating tumor infiltration and T-cell activation

Shujuan Zhou et al.

Summary: The study introduced a novel bifunctional agent, iRGD-anti-CD3, to enhance T cell infiltration, activation, and cytotoxicity against target cancer cells. The modification significantly inhibited tumor growth and prolonged survival in xenograft mouse models, with additional improvement seen when combined with PD-1 blockade. Mechanistic studies revealed the potential of iRGD-anti-CD3 in promoting T cell extravasation through a transport pathway called vesiculovacuolar organelles in the endothelial cytoplasm.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

CD137 as an Attractive T Cell Co-Stimulatory Target in the TNFRSF for Immuno-Oncology Drug Development

Kenji Hashimoto

Summary: CD137 is a significant immuno-oncology target that provides co-stimulatory signals and activates cytotoxic effects of T cells. Recent advances in targeting technologies have shown promising clinical efficacy signals, but challenges regarding toxicity and potency remain. Further investigation is needed to optimize combination strategies involving CD137 targeting agents for improved clinical safety and efficacy in cancer immunotherapy.

CANCERS (2021)

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Article Oncology

The TIM3/Gal9 signaling pathway: An emerging target for cancer immunotherapy

Sashi Kandel et al.

Summary: The blockade of the TIM3/Gal9 pathway shows promising therapeutic potential in cancer treatment, by enhancing immune response and overcoming immune resistance. TIM3 and Gal9 may also serve as prognostic and predictive biomarkers in different types of cancers.

CANCER LETTERS (2021)

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Article Pharmacology & Pharmacy

Modulation of the tumor microenvironment (TME) by melatonin

Qi Mu et al.

Summary: The interactions between cells and molecules released in the tumor microenvironment play a crucial role in tumor growth and suppression of antitumoral immunity. Melatonin affects other cells within the TME by modulating cell activity and the release of cytokines.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance

Triet M. Bui et al.

Summary: With the emerging phenotypic and functional heterogeneity of TANs, targeting specific TAN functions in developing tumors can lead to translatable therapeutic approaches and limit drug resistance. We propose that combining specific targeting of TAN activity with standard cancer therapy can help patients achieving a complete response and prevent cancer relapse.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity

A. Stoll et al.

Summary: CD137 plays a crucial role in monocytes, and its agonists may have therapeutic implications in combination with tumor-targeting antibodies, potentially showing synergistic effects.

LEUKEMIA (2021)

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Article Oncology

Expression of Immune Checkpoint Regulators IDO, VISTA, LAG3, and TIM3 in Resected Pancreatic Ductal Adenocarcinoma

Felix C. Popp et al.

Summary: Pancreatic cancer is highly resistant to immune checkpoint inhibitors. The potential of new immune molecules to restore the antitumor immune response was explored, with IDO expression associated with improved survival while VISTA, LAG3, and TIM3 expression were not correlated with survival. The study suggests that immune checkpoint inhibitors targeting VISTA, LAG3, and TIM3 may be inefficient in clinical application.

CANCERS (2021)

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Article Oncology

Calmodulin 2 Facilitates Angiogenesis and Metastasis of Gastric Cancer via STAT3/HIF-1A/VEGF-A Mediated Macrophage Polarization

Ganggang Mu et al.

Summary: The study revealed that CALM2 expression was elevated in GC tissues and cell lines, correlating with poor prognosis in GC patients. Both in vitro and in vivo experiments demonstrated that CALM2 could enhance tumor growth and lung metastasis, as well as promoting proliferation, migration, invasion, angiogenesis, and macrophage polarization. Mechanistically, CALM2 activated the JAK2/STAT3/HIF-1/VEGFA signaling pathway, facilitating GC metastasis and angiogenesis. Inhibition of JAK2 and HIF-1A attenuated the promoting effects of CALM2 on tumor cells, endothelial cells, and macrophages.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment

Yanyu Huang et al.

Summary: Evasion of immune surveillance is a hallmark of tumor progression, with tumor-secreted Gal-1 binding to immune cell receptors and suppressing immune cell function in the tumor microenvironment, contributing to tumor immune escape. Therapeutics targeting Gal-1 are being explored as a potential strategy to overcome this immune suppression in tumors.

BIOMOLECULES (2021)

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Article Oncology

Bevacizumab biosimilar LY01008 compared with bevacizumab (Avastin) as first-line treatment for Chinese patients with unresectable, metastatic, or recurrent non-squamous non-small-cell lung cancer: A multicenter, randomized, double-blinded, phase III trial

Yuankai Shi et al.

Summary: LY01008 and Avastin demonstrated similar efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC, with no significant differences observed between the two treatments.

CANCER COMMUNICATIONS (2021)

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Article

Role of tumor/endothelial cell interactions in tumor growth and metastasis

O.N. Pyaskovskaya et al.

Experimental Oncology (2021)

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Review Biochemistry & Molecular Biology

B7-H3 Immune Checkpoint Protein in Human Cancer

Karine Flem-Karlsen et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Tumor angiogenesis: causes, consequences, challenges and opportunities

Roberta Lugano et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Review Biotechnology & Applied Microbiology

Role of Inducible Co-Stimulator (ICOS) in cancer immunotherapy

Florent Amatore et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

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Review Pathology

Endothelial Cell Calcium Signaling during Barrier Function and Inflammation

Prarthana J. Dalal et al.

AMERICAN JOURNAL OF PATHOLOGY (2020)

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Review Oncology

Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Xu Lei et al.

CANCER LETTERS (2020)

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Article Oncology

Low-Dose Anti-Angiogenic Therapy Sensitizes Breast Cancer to PD-1 Blockade

Qian Li et al.

CLINICAL CANCER RESEARCH (2020)

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Article Immunology

CTLA-4: From mechanism to autoimmune therapy

Arezoo Hosseini et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Oncology

CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils

Xichen Zheng et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Cell Biology

B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression

Ruoqin Wang et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

Response and outcomes after anti-CTLA4 versus anti-PD1 combined with stereotactic body radiation therapy for metastatic non-small cell lung cancer: retrospective analysis of two single-institution prospective trials

Dawei Chen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Oncology

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies

Mark P. Chao et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Oncology

TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation

Yasuhiro Yoshimatsu et al.

CANCER SCIENCE (2020)

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Article Cell Biology

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

Katerina Rohlenova et al.

CELL METABOLISM (2020)

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Article Chemistry, Multidisciplinary

Immunotherapy of experimental melanoma with ICOS-Fc loaded in biocompatible and biodegradable nanoparticles

Nausicaa Clemente et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Cell Biology

anlotinib alters tumor immune microenvironment by downregulating PD-L1 expression on vascular endothelial cells

Shaochuan Liu et al.

CELL DEATH & DISEASE (2020)

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Review Oncology

Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook

Josep Garcia et al.

CANCER TREATMENT REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells

Yizi Cong et al.

BIOSCIENCE REPORTS (2020)

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Article Oncology

Tumor Endothelial Cell-Mediated Antigen-Specific T-cell Suppression via the PD-1/PD-L1 Pathway

Kazuhiro Taguchi et al.

MOLECULAR CANCER RESEARCH (2020)

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Review Polymer Science

iRGD Peptide as a Tumor-Penetrating Enhancer for Tumor-Targeted Drug Delivery

Sujin Kang et al.

POLYMERS (2020)

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Review Medicine, General & Internal

CAR-NK cells: A promising cellular immunotherapy for cancer

Guozhu Xie et al.

EBIOMEDICINE (2020)

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Review Cell Biology

Endothelial-to-Mesenchymal Transition in Cancer

Nicolas Clere et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biology

Osteopontin binds ICOSL promoting tumor metastasis

Davide Raineri et al.

COMMUNICATIONS BIOLOGY (2020)

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Review Cell Biology

NOX2-Derived Reactive Oxygen Species in Cancer

Hanna Grauers Wiktorin et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells

Yizi Cong et al.

CHINESE JOURNAL OF CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Xiaoliang Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

Tumor microenvironmental influences on dendritic cell and T cell function: A focus on clinically relevant immunologic and metabolic checkpoints

Kristian M. Hargadon

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Review Oncology

The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy

Cinzia Solinas et al.

ESMO OPEN (2020)

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Review Immunology

TIM3 comes of age as an inhibitory receptor

Yochai Wolf et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Oncology

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

Maria Georganaki et al.

ONCOIMMUNOLOGY (2020)

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Review Oncology

CD8+ T cell states in human cancer: insights from single-cell analysis

Anne M. Van der Leun et al.

NATURE REVIEWS CANCER (2020)

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Article Oncology

B7-H3 Expression in Merkel Cell Carcinoma-Associated Endothelial Cells Correlates with Locally Aggressive Primary Tumor Features and Increased Vascular Density

Phyu P. Aung et al.

CLINICAL CANCER RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Targeting Tumor Microenvironment for Cancer Therapy

Catarina Roma-Rodrigues et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Immunology

The Interplay between MicroRNAs and Cellular Components of Tumour Microenvironment (TME) on Non-Small-Cell Lung Cancer (NSCLC) Progression

Sook Shien Lee et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2019)

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Article Biotechnology & Applied Microbiology

IFN-gamma and TNF-alpha aggravate endothelial damage caused by CD123-targeted CAR T cell

Yao Sun et al.

ONCOTARGETS AND THERAPY (2019)

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Article Cell Biology

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

Pawel Bieniasz-Krzywiec et al.

CELL METABOLISM (2019)

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Review Biochemistry & Molecular Biology

Vascular Endothelial Cell Biology: An Update

Anne Krueger-Genge et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Cell Biology

Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer

Musbau Adewumi Akanji et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Immunology

NK Cell Metabolism and Tumor Microenvironment

Inigo Terren et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Medicine, Research & Experimental

Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells

Farnaz Hajizadeh et al.

LIFE SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Xinming Jing et al.

MOLECULAR CANCER (2019)

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Article Peripheral Vascular Disease

Interleukin-22 promotes tumor angiogenesis

Nicholas J. Protopsaltis et al.

ANGIOGENESIS (2019)

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Review Oncology

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

Maria Teresa Masucci et al.

FRONTIERS IN ONCOLOGY (2019)

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Editorial Material Oncology

NOX2 in autoimmunity, tumor growth and metastasis

Anna Martner et al.

JOURNAL OF PATHOLOGY (2019)

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Review Immunology

CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment

Marina Martinez et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Selectins in cancer immunity

Lubor Borsig

GLYCOBIOLOGY (2018)

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Review Oncology

Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics

Priti S. Hegde et al.

SEMINARS IN CANCER BIOLOGY (2018)

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Article Cell Biology

A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells

Sukhbir Kaur et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2018)

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Article Engineering, Biomedical

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

Ju Hun Yeon et al.

ACTA BIOMATERIALIA (2018)

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Article Oncology

High IDO-1 expression in tumor endothelial cells is associated with response to immunotherapy in metastatic renal cell carcinoma

Andreas Seeber et al.

CANCER SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model

Ran An et al.

FASEB JOURNAL (2018)

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Review Immunology

Human T Cell Development, Localization, and Function throughout Life

Brahma V. Kumar et al.

IMMUNITY (2018)

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Review Biochemistry & Molecular Biology

Contribution of Tumor Endothelial Cells in Cancer Progression

Kyoko Hida et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Laia Caja et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Deok-Hoon Kong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Medicine, General & Internal

Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer The FRESCO Randomized Clinical Trial

Jin Li et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Article Biochemistry & Molecular Biology

Phenotype molding of stromal cells in the lung tumor microenvironment

Diether Lambrechts et al.

NATURE MEDICINE (2018)

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Article Oncology

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

Dal Fukurnura et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Immunology

SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy

Andre Veillette et al.

TRENDS IN IMMUNOLOGY (2018)

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Article Immunology

High Indoleamine 2,3-Dioxygenase Is Correlated With Microvessel Density and Worse Prognosis in Breast Cancer

Lijuan Wei et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Targeting veGF/veGFR to Modulate Antitumor immunity

Ju Yang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

IFN gamma-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

Ryan S. Lane et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

Ian P. Harrison et al.

Oncotarget (2018)

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Review Oncology

Distant Relations: Macrophage Functions in the Metastatic Niche

Geneva R. Doak et al.

TRENDS IN CANCER (2018)

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Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

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Article Oncology

CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis

Lu Gao et al.

ONCOTARGET (2017)

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Article Oncology

Endothelial cell-cell adhesion and signaling

Camilla Cerutti et al.

EXPERIMENTAL CELL RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Fine-Tuning Tumor Endothelial Cells to Selectively Kill Cancer

Emilie Uldry et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Oncology

MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells

Zhong Zheng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Article Oncology

Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway

Hao-Wei Cheng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Review Oncology

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

Mizuki Nishino et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Editorial Material Biochemistry & Molecular Biology

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer

Xin Chen et al.

SCIENCE SIGNALING (2017)

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Article Cell Biology

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Martina Schmittnaegel et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Review Biochemistry & Molecular Biology

TNFR2: A Novel Target for Cancer Immunotherapy

Eva S. Vanamee et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Article Oncology

NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27

Alessandra Dondero et al.

ONCOTARGET (2017)

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Article Biology

Endothelial cells express NKG2D ligands and desensitize antitumor NK responses

Thornton W. Thompson et al.

ELIFE (2017)

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Editorial Material Biochemistry & Molecular Biology

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer

Xin Chen et al.

SCIENCE SIGNALING (2017)

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Article Oncology

Myeloid-Derived Suppressor Cells

Dmitry I. Gabrilovich

CANCER IMMUNOLOGY RESEARCH (2017)

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Article Oncology

Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone

Ana E. Paiva et al.

NEOPLASIA (2017)

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Review Peripheral Vascular Disease

Tumor angiogenesis and vascular normalization: alternative therapeutic targets

Claire Viallard et al.

ANGIOGENESIS (2017)

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Review Oncology

Tumor endothelial cells accelerate tumor metastasis

Nako Maishi et al.

CANCER SCIENCE (2017)

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Article Cell Biology

Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer

Song-Chang Lin et al.

DEVELOPMENTAL CELL (2017)

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Article Oncology

Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA

Quanfeng Wu et al.

CANCER CELL INTERNATIONAL (2017)

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Article Oncology

Endothelial Notch1 Activity Facilitates Metastasis

Elfriede Wieland et al.

CANCER CELL (2017)

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Review Oncology

Tumor microenvironment and therapeutic response

Ting Wu et al.

CANCER LETTERS (2017)

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Article Oncology

Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells

Zhongwei Cao et al.

CANCER CELL (2017)

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Review Oncology

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

J. M. Pitt et al.

ANNALS OF ONCOLOGY (2016)

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Review Hematology

Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation

Natalia Reglero-Real et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Human umbilical vein endothelial cells promote the inhibitory activation of CD4(+)CD25(+)Foxp3(+) regulatory T cells via PD-L1

Wei-Jun Chen et al.

ATHEROSCLEROSIS (2016)

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Review Medicine, Research & Experimental

NOX2-dependent regulation of inflammation

Kelly L. Singel et al.

CLINICAL SCIENCE (2016)

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Review Biotechnology & Applied Microbiology

Endothelial Progenitor Cells as Shuttle of Anticancer Agents

Anna Laurenzana et al.

HUMAN GENE THERAPY (2016)

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Review Pharmacology & Pharmacy

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Caroline Wigerup et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Review Immunology

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Vinit Kumar et al.

TRENDS IN IMMUNOLOGY (2016)

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Article Oncology

Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment

Luuk van Hooren et al.

ONCOTARGET (2016)

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Article Oncology

VEGF Neutralization Plus CTLA-4 Blockade Alters Soluble and Cellular Factors Associated with Enhancing Lymphocyte Infiltration and Humoral Recognition in Melanoma

Xinqi Wu et al.

CANCER IMMUNOLOGY RESEARCH (2016)

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Article Multidisciplinary Sciences

Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-α-induced apoptosis

Chen-Pin Chou et al.

SCIENTIFIC REPORTS (2016)

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Article Pharmacology & Pharmacy

The enhancement of gene silencing efficiency with chitosan-coated liposome formulations of siRNAs targeting HIF-1α and VEGF

Emine Salva et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Multidisciplinary Sciences

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer

Rebecca S. Heist et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Multidisciplinary Sciences

The future of immune checkpoint therapy

Padmanee Sharma et al.

SCIENCE (2015)

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Article Oncology

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

Rakesh K. Jain

CANCER CELL (2014)

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Review Oncology

Monocyte Subpopulations in Angiogenesis

Heather J. Dalton et al.

CANCER RESEARCH (2014)

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Article Oncology

Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer

Eun-Jin Yeo et al.

CANCER RESEARCH (2014)

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Review Biochemistry & Molecular Biology

Roles of VEGF-A signalling in development, regeneration, and tumours

Ken Matsumoto et al.

JOURNAL OF BIOCHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

Gregory T. Motz et al.

NATURE MEDICINE (2014)

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Article Medicine, General & Internal

Improved Survival with Bevacizumab in Advanced Cervical Cancer

Krishnansu S. Tewari et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Biotechnology & Applied Microbiology

B7-H3 expression in breast cancer and upregulation of VEGF through gene silence

Jing Sun et al.

ONCOTARGETS AND THERAPY (2014)

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Article Multidisciplinary Sciences

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling

Hong Ji et al.

NATURE COMMUNICATIONS (2014)

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Article Cell & Tissue Engineering

Antitumor Effects of CD40 Ligand-Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model

Yovita Ida Purwanti et al.

STEM CELLS TRANSLATIONAL MEDICINE (2014)

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Review Biotechnology & Applied Microbiology

Targeting Mast Cells Tryptase in Tumor Microenvironment: A Potential Antiangiogenetic Strategy

Michele Ammendola et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Oncology

Bevacizumab plus Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

CANCER IMMUNOLOGY RESEARCH (2014)

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Article Oncology

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

Andrea Casazza et al.

CANCER CELL (2013)

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Review Oncology

Angiopoietins in angiogenesis

Ernesta Fagiani et al.

CANCER LETTERS (2013)

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Article Oncology

Interaction of monocytes/macrophages with ovarian cancer cells promotes angiogenesis in vitro

Xipeng Wang et al.

CANCER SCIENCE (2013)

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Review Oncology

Cell Trafficking of Endothelial Progenitor Cells in Tumor Progression

Pilar de la Puente et al.

CLINICAL CANCER RESEARCH (2013)

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Review Biochemistry & Molecular Biology

The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity

Fabien B. Vincent et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

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Article Medicine, Research & Experimental

Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice

Hanseul Yanh et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Oncology

Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates

Jing Lu et al.

ONCOLOGY REPORTS (2013)

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Article Multidisciplinary Sciences

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

Chunmei Yang et al.

PLOS ONE (2013)

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Article Oncology

Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B

Y. Guo et al.

NEOPLASMA (2013)

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Article Oncology

Primary anti-vascular endothelial growth factor (VEGF)-refractory metastatic renal cell carcinoma: clinical characteristics, risk factors, and subsequent therapy

D. Y. Heng et al.

ANNALS OF ONCOLOGY (2012)

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Article Biochemistry & Molecular Biology

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

Swarnali Acharyya et al.

CELL (2012)

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Article Immunology

Stromal Endothelial Cells Establish a Bidirectional Crosstalk with Chronic Lymphocytic Leukemia Cells through the TNF-Related Factors BAFF, APRIL, and CD40L

Montserrat Cols et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Medicine, Research & Experimental

Endothelial Cell Heterogeneity

William C. Aird

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

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Article Oncology

Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met

Kelly L. Mueller et al.

BREAST CANCER RESEARCH (2012)

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Review Oncology

Cancer immunotherapy via dendritic cells

Karolina Palucka et al.

NATURE REVIEWS CANCER (2012)

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Article Biochemistry & Molecular Biology

CD40/CD4OL interaction induces E-selectin dependent leukocyte adhesion to human endothelial cells and inhibits endothelial cell migration

Daniel Urban et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

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Article Oncology

Angiocrine Factors Modulate Tumor Proliferation and Motility through EphA2 Repression of Slit2 Tumor Suppressor Function in Endothelium

Dana M. Brantley-Sieders et al.

CANCER RESEARCH (2011)

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Article Oncology

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

Asis Palazon et al.

CANCER RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Tumor angiogenesis: molecular pathways and therapeutic targets

Sara M. Weis et al.

NATURE MEDICINE (2011)

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Article Oncology

Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors

Wiem Lassoued et al.

CANCER BIOLOGY & THERAPY (2010)

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Article Biochemistry & Molecular Biology

MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma

Jing Lu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

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Article Immunology

Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion

Xiaoyuan Huang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

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Article Oncology

Tumor Secretion of VEGF Induces Endothelial Cells to Suppress T cell Functions Through the Production of PGE2

Jennifer K. Mulligan et al.

JOURNAL OF IMMUNOTHERAPY (2010)

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Article Peripheral Vascular Disease

Involvement of endothelial progenitor cells in tumor vascularization

Alexandre Patenaude et al.

MICROVASCULAR RESEARCH (2010)

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Article Pathology

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

Xingxing Zang et al.

MODERN PATHOLOGY (2010)

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Review Cell Biology

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

Sussan Nourshargh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

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Article Immunology

Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions

Jennifer K. Mulligan et al.

HUMAN IMMUNOLOGY (2009)

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Article Cell Biology

Radioprotection in Normal Tissue and Delayed Tumor Growth by Blockade of CD47 Signaling

Justin B. Maxhimer et al.

SCIENCE TRANSLATIONAL MEDICINE (2009)

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Review Immunology

PD-1 and its ligands in tolerance and immunity

Mary E. Keir et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

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Article Immunology

Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines

H. Kanno et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2008)

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Article Oncology

Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma

Paul L. Crispen et al.

CLINICAL CANCER RESEARCH (2008)

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Article Oncology

The Interleukin-8 Pathway in Cancer

David J. J. Waugh et al.

CLINICAL CANCER RESEARCH (2008)

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Article Oncology

Tumors skew endothelial cells to disrupt NK cell, T-cell and macrophage functions

Jennifer K. Mulligan et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2008)

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Review Oncology

Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoletin-2

Claire E. Lewis et al.

CANCER RESEARCH (2007)

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Article Oncology

Genes that distinguish physiological and pathological angiogenesis

Steven Seaman et al.

CANCER CELL (2007)

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Article Immunology

Differentiation of human tumour-associated dendritic cells into endothelial-like cells: An alternative pathway of tumour angiogenesis

E. Gottfried et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2007)

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Review Immunology

Getting to the site of inflammation: the leukocyte adhesion cascade updated

Klaus Ley et al.

NATURE REVIEWS IMMUNOLOGY (2007)

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Article Immunology

Triggering CD40 on endothelial cells contributes to tumor growth

Claudia Chiodoni et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

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Article Medicine, Research & Experimental

Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration

Jiale He et al.

LABORATORY INVESTIGATION (2006)

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Review Biochemistry & Molecular Biology

Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy

N Ferrara et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Oncology

Transendothelial migration of myeloma cells is increased by tumor necrosis factor (TNF)-α via TNF receptor 2 and autocrine up-regulation of MCP-1

K Jöhrer et al.

CLINICAL CANCER RESEARCH (2004)

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Article Immunology

Endothelial expression of PD-L1 and PD-L2 down-regulates CD8(+) T cell activation and cytolysis

N Rodig et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

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