Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma

Review Biochemistry & Molecular Biology

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

Junwei Hou et al.

Summary: ICP and CCP are processes of cell pyroptosis activated by different molecular mechanisms, affecting antitumor immunity and therapeutic outcomes.

MOLECULAR CELL (2021)

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Review Immunology

NLRP3 inflammasome in cancer and metabolic diseases

Bhesh Raj Sharma et al.

Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.

NATURE IMMUNOLOGY (2021)

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Review Immunology

Inflammasomes and adaptive immune responses

Katherine A. Deets et al.

Summary: Recent research highlights the complex relationship between inflammasomes and adaptive immunity, focusing on how inflammasome activation influences the release of cytokines and antigens, shaping or inhibiting adaptive immune responses. Different tissue or cellular contexts may alter the effects of inflammasome activation on adaptive immunity, contributing to beneficial or detrimental outcomes in infectious diseases, cancer, and autoimmunity. The discussion by Deets and Vance explores the impact of inflammasome activation on adaptive immunity.

NATURE IMMUNOLOGY (2021)

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Review Oncology

Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al.

Summary: Pyroptosis is an inflammatory form of cell death with tumor suppressive function and the ability to evoke anti-tumor immune responses. Cancer therapies induce pyroptosis, enhancing anti-tumor immunity, but also leading to side effects on normal cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Immunology

NLRP3 inflammasome activation and cell death

Yi Huang et al.

Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Oncology

Pyroptosis at the forefront of anticancer immunity

Reid Loveless et al.

Summary: Pyroptosis, a lytic and inflammatory programmed cell death pathway, has shown potential in addressing tumor resistance to apoptosis and the immunosuppressive tumor microenvironment by inducing a robust inflammatory response and marked tumor regression. Gasdermin proteins mediate pyroptosis and facilitate immune cell activation and infiltration, but aberrant pyroptosis may also contribute to tumor progression by upregulating gasdermin proteins in certain cancers. Harnessing pyroptosis as a tool in anticancer strategies shows promise in novel interventions.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Medicine, Research & Experimental

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Sheng-Kai Hsu et al.

Summary: New types of programmed cell death, such as ferroptosis, necroptosis, and pyroptosis, have emerged in recent years, playing significant roles in cancer progression modulation and being closely related to immune regulation in the tumor microenvironment. Pyroptosis, in particular, has been identified as crucial for host defense and bridging innate and adaptive immunity, showing benefits for cancer immunotherapies.

THERANOSTICS (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Gastroenterology & Hepatology

Intrahepatic recurrence of hepatocellular carcinoma after resection: an update

Maria Tampaki et al.

Summary: Hepatocellular carcinoma recurrence is common after hepatic resection, but there is currently no established guidance for management. By evaluating prognostic factors and implementing appropriate strategies, the risk of relapse can be reduced and overall survival improved.

CLINICAL JOURNAL OF GASTROENTEROLOGY (2021)

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Review Biochemistry & Molecular Biology

Challenges in liver cancer and possible treatment approaches

David Anwanwan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Article Cell Biology

Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases

Ilaria Genovese et al.

CELL DEATH & DISEASE (2020)

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Article Pharmacology & Pharmacy

Alpinumisoflavone suppresses hepatocellular carcinoma cell growth and metastasis via NLRP3 inflammasome-mediated pyroptosis

Yan Zhang et al.

PHARMACOLOGICAL REPORTS (2020)

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Review Oncology

NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases

Yucheng Wang et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Article Gastroenterology & Hepatology

Expression of Metastatic Tumor Antigen 1 Splice Variant Correlates With Early Recurrence and Aggressive Features of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Yung-Tsung Li et al.

HEPATOLOGY (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Cell Biology

Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+-mediated apoptosis pathways in MCF-7/ADR and K562/ADR

Yaoting Sun et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Immunology

Apoptosis and Clearance of Apoptotic Cells

Shigekazu Nagata

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

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Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Oncology

Sorcin a Potential Molecular Target for Cancer Therapy

Bano Shabnam et al.

TRANSLATIONAL ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Role of the NLRP3 inflammasome in cancer

Maryam Moossavi et al.

MOLECULAR CANCER (2018)

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Article Cell Biology

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

Ilaria Genovese et al.

CELL DEATH & DISEASE (2017)

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Article Oncology

Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

Huan Tuo et al.

ONCOTARGET (2017)

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Review Immunology

Programmed cell death as a defence against infection

Ine Jorgensen et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Oncology

International trends in liver cancer incidence, overall and by histologic subtype, 1978-2007

Jessica L. Petrick et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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Review Biochemistry & Molecular Biology

Mechanism and Regulation of NLRP3 Inflammasome Activation

Yuan He et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Article Biochemistry & Molecular Biology

Sorcin Enhances Metastasis and Promotes Epithelial-to-Mesenchymal Transition of Colorectal Cancer

Weihua Tong et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2015)

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Article Immunology

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity

Jeremy Dupaul-Chicoine et al.

IMMUNITY (2015)

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Article Medicine, Research & Experimental

Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome

Qing Wei et al.

LABORATORY INVESTIGATION (2015)

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Article Oncology

Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells

Yanyan Gao et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Anatomy & Morphology

Reversing Effect of Sorcin in the Drug Resistance of Human Nasopharyngeal Carcinoma

Xuebing Liu et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Increased expression of sorcin is associated with multidrug resistance in leukemia cells via up-regulation of MDR1 expression through cAMP response element-binding protein

Nobuyuki Yamagishi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Article Oncology

Sorcin silencing inhibits epithelial-to-mesenchymal transition and suppresses breast cancer metastasis in vivo

Yunhui Hu et al.

BREAST CANCER RESEARCH AND TREATMENT (2014)

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Article Medicine, Research & Experimental

Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression

Qing Wei et al.

LABORATORY INVESTIGATION (2014)

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Review Cell Biology

Inflammasomes and Their Roles in Health and Disease

Mohamed Lamkanfi et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 28 (2012)

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Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Article Multidisciplinary Sciences

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Geun-Shik Lee et al.

NATURE (2012)

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Article Oncology

Sorcin Induces a Drug-Resistant Phenotype in Human Colorectal Cancer by Modulating Ca2+ Homeostasis

Francesca Maddalena et al.

CANCER RESEARCH (2011)

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Review Microbiology

Pyroptosis: host cell death and inflammation

Tessa Bergsbaken et al.

NATURE REVIEWS MICROBIOLOGY (2009)

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Article Pharmacology & Pharmacy

Knock-down of sorcin induces up-regulation of MDR1 in HeLa cells

Megumi Kawakami et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2007)

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Article Biochemistry & Molecular Biology

The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor

Gianni Colotti et al.

BIOCHEMISTRY (2006)

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Article Oncology

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Kurt Degenhardt et al.

CANCER CELL (2006)

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Article Pharmacology & Pharmacy

Differential regulation of calcium homeostasis in adenocarcinoma cell line A549 and its Taxol-resistant subclone

S Padar et al.

BRITISH JOURNAL OF PHARMACOLOGY (2004)

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Article Pharmacology & Pharmacy

Overexpression of sorcin, a calcium-binding protein, induces a low level of paclitaxel resistance in human ovarian and breast cancer cells

HK Parekh et al.

BIOCHEMICAL PHARMACOLOGY (2002)

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Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma

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