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Ferroptosis as a potential target for cancer therapy

CELL DEATH & DISEASE (2023)

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Article Biochemistry & Molecular Biology

Reactive Oxygen Species and Ferroptosis at the Nexus of Inflammation and Colon Cancer

Wesley Huang et al.

Summary: This article suggests that excess reactive oxygen species (ROS) are implicated in intestinal inflammation and cancer, and inhibiting ROS may improve the severity of inflammatory bowel disease (IBD) while activating ROS limits the progression of colorectal cancer (CRC). Further research on the inflammatory and tumor microenvironment in the intestine may lead to novel therapeutic approaches.

ANTIOXIDANTS & REDOX SIGNALING (2023)

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Article Hematology

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

Rudy Birsen et al.

Summary: APR 246 is a promising therapeutic agent for myelodysplastic syndromes and acute myeloid leukemia that targets p53 mutated proteins. It has been found to reactivate the transcriptional activity of p53 mutants and induce p53-independent cell death. The study also demonstrates the association between APR 246 and ferroptosis, a recently described cell death process. The detoxification capacity of AML cells to maintain glutathione biosynthesis may play a key role in determining sensitivity to APR 246.

HAEMATOLOGICA (2022)

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Article Biochemistry & Molecular Biology

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

Wen Zhang et al.

Summary: In this study, we reported for the first time that Bufotalin (BT), a natural small molecule, is a glutathione peroxidase 4 (GPX4) inhibitor that can trigger ferroptosis in non-small cell lung cancer cells. BT induces ferroptosis and lipid peroxidation by accelerating GPX4 degradation and increasing intracellular Fe2+.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer

Man Jiang et al.

JOURNAL OF BIOCHEMISTRY (2022)

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Article Oncology

Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53

Junhui Li et al.

MOLECULAR CANCER THERAPEUTICS (2022)

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Article Biochemistry & Molecular Biology

MiR-15a-3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer

Liurong Liu et al.

Summary: miR-15a-3p positively regulates ferroptosis in CRC by targeting GPX4, leading to increased levels of reactive oxygen species and malondialdehyde accumulation with overexpression, while reducing sensitivity to erastin and GPX4 with suppression.

MOLECULAR CARCINOGENESIS (2022)

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Article Cell Biology

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Hai-Liang Zhang et al.

Summary: Through CRISPR-Cas9 and kinase inhibitor screening, Zhang et al. found that PKC beta II phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.

NATURE CELL BIOLOGY (2022)

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Article Oncology

Silencing lncRNA SLC16A1-AS1 Induced Ferroptosis in Renal Cell Carcinoma Through miR-143-3p/SLC7A11 Signaling

Yan Ze Li et al.

Summary: In this study, it was revealed that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR-143-3p/SLC7A11 signaling pathway in renal cancer. The results provided a novel view into the pathogenesis and treatment strategy of RCC.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2022)

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Article Oncology

MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression

Po Xu et al.

Summary: This study found that miR-15a induces ferroptosis by regulating GPX4 in prostate cancer cells. Transfection with miR-15a mimics or si-GPX4 suppressed cell proliferation and increased cell death and ROS accumulation. These findings provide important insights for the investigation of therapeutic strategies for prostate cancer.

ONCOLOGY LETTERS (2022)

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Review Oncology

Ferroptosis in cancer and cancer immunotherapy

Lei Zhao et al.

Summary: Ferroptosis, a newly identified type of cell death dependent on lipid peroxidation, plays a vital role in cancer treatment as a potential strategy to overcome drug resistance in traditional therapies.

CANCER COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro

Jing Zhang et al.

Summary: Alloimperatorin inhibits breast cancer cell growth and invasion by inducing apoptosis, ferroptosis, and oxeiptosis.

BIOCHEMISTRY AND CELL BIOLOGY (2022)

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Article Oncology

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

Peng Liao et al.

Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.

CANCER CELL (2022)

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Review Biochemistry & Molecular Biology

Signaling pathways and defense mechanisms of ferroptosis

Jiao Liu et al.

Summary: Ferroptosis is a type of lytic cell death caused by unrestricted lipid peroxidation and cell membrane damage, driven by complex signaling pathways and regulatory mechanisms. The main substrates of lipid peroxidation in ferroptosis are phospholipids rich in polyunsaturated fatty acids, positively regulated by various enzymes. Selective activation of autophagic degradation pathways promotes ferroptosis, while the system xc(-)-glutathione-GPX4 axis plays a limiting role.

FEBS JOURNAL (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis at the intersection of lipid metabolism and cellular signaling

Deguang Liang et al.

Summary: This review provides a comprehensive analysis of the mechanisms and signaling pathways involved in ferroptosis, focusing on the impact of lipid metabolism and the potential for therapeutic strategies targeting this interaction.

MOLECULAR CELL (2022)

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Editorial Material Biochemistry & Molecular Biology

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Paul A. Cobine et al.

Summary: Tsvetkov et al. (2022) identified a novel form of cell death caused by targeted accumulation of Cu in mitochondria, which leads to aggregation of lipoylated TCA cycle enzymes through direct Cu binding.

MOLECULAR CELL (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Review Cell Biology

Interaction between macrophages and ferroptosis

Yan Yang et al.

Summary: Ferroptosis is a newly discovered iron-dependent cell death pathway characterized by lipid peroxidation and GSH depletion, participating in the development of various diseases. Macrophages, as immune cells, play crucial roles in regulating iron, lipid, and amino acid metabolisms, and recent studies target their polarization to induce ferroptosis in cancer cells for treatment.

CELL DEATH & DISEASE (2022)

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Article Biotechnology & Applied Microbiology

Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway

Jianli Hao et al.

Summary: This study aimed to investigate the effects of local anesthetic bupivacaine on bladder cancer cells. The results showed that bupivacaine inhibited cell activity, promoted apoptosis, and affected mitochondrial membrane potential, oxidative stress, and the PI3K/Akt signaling pathway in bladder cancer cells.

BIOENGINEERED (2022)

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Article Biochemistry & Molecular Biology

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Shumin Ouyang et al.

Summary: Inhibition of STAT3 can trigger ferroptosis and provide a new therapeutic strategy for gastric cancer and chemotherapy resistance. STAT3 negatively regulates the FNR associated genes and establishes a negative STAT3-ferroptosis regulatory axis in gastric cancer. A selective STAT3 inhibitor, W1131, shows significant anti-tumor effects in gastric cancer models by inducing ferroptosis and restores sensitivity to chemotherapy.

REDOX BIOLOGY (2022)

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Article Oncology

Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway

Yingyi Xu et al.

Summary: This study revealed that Sev induced ferroptosis in glioma cells through the ATF4-CHAC1 pathway. Treatment with Sev resulted in decreased cell viability, increased ROS levels and Fe+ concentration, downregulated protein expression of GPX4, and upregulated expression of transferrin, ferritin, and Beclin-1 in glioma cells. Transcriptional sequencing analysis showed that Sev enhanced the expression of ATF4, a gene associated with ferroptosis and mitophagy. Inhibition of ATF4 interrupted the expression of CHAC1 induced by Sev in glioma cells.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis

Rongying Ou et al.

Summary: The study demonstrated that circLMO1 acts as a tumor suppressor in cervical cancer by down-regulating miR-4291/ACSL4-mediated ferroptosis, providing a potential biomarker for clinical management of cervical cancer. CircLMO1 overexpression inhibited cervical cancer cell proliferation and invasion, while depletion promoted these processes. CircLMO1 functions as a competing endogenous RNA by interacting with miR-4192 and ACSL4 to regulate cervical cancer development.

FRONTIERS IN ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment

Mingbo Wu et al.

Summary: This study developed nano-crystals with both PDT and ferroptosis therapeutic effects by utilizing the photosensitizer aloe-emodin. These nano-crystals showed significant enhanced therapeutic effects for combined antitumor mechanisms.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Engineering, Biomedical

Engineering dual catalytic nanomedicine for autophagy-augmented and ferroptosis-involved cancer nanotherapy

Zhifang Li et al.

Summary: In this study, a liposomal nanosystem was constructed to achieve autophagy-enhanced and ferroptosis-involved cancer cell death using a Cu-based dual catalytic strategy. The results demonstrated the significant therapeutic efficacy of this system and provided a potential approach for suppressing tumor growth.

BIOMATERIALS (2022)

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Article Biochemistry & Molecular Biology

Flavonoid 4,4′-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH

Changmei Yang et al.

Summary: In this study, we found that 4,4'-dimethoxychalcone (DMC) induces ferroptosis in cancer cells by activating the Keap1/Nrf2/HMOX1 pathway and inhibiting ferrochelatase (FECH). These findings shed light on the mechanisms of DMC in inhibiting cancer cell growth and provide a new insight into the biological functions of flavonoids.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Review Oncology

ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers

Yufei Yang et al.

Summary: ACSL3 and ACSL4, members of the long-chain fatty acyl CoA synthetase family, play roles in various cancer cells. They are essential for ferroptosis and have implications in cancer initiation, development, and treatment.

CANCERS (2022)

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Article Engineering, Biomedical

Engineering Fe/Mn-doped zinc oxide nanosonosensitizers for ultrasound-activated and multiple ferroptosis-augmented nanodynamic tumor suppression

Zhongqian Hu et al.

Summary: Fe and Mn co-doped zinc oxide nanosonosensitizers have been designed and engineered to enhance sonodynamic therapy efficiency against tumors by inducing both ferroptosis and apoptosis of tumor cells. The doping of Fe/Mn into the nanostructure of ZnO nanosonosensitizers catalyzes the Fenton reaction to produce ROS in the tumor microenvironment and deplete intracellular glutathione. This enhances the separation and inhibits the recombination of e-/h+ under ultrasound activation.

MATERIALS TODAY BIO (2022)

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Review Cell Biology

Regulatory pathways and drugs associated with ferroptosis in tumors

Dan Wang et al.

Summary: In this article, we reviewed the regulation of ferroptosis in tumor cells and introduced the tumor-related signaling pathways of ferroptosis. Special attention was given to the role of noncoding RNA, nanomaterials, drug effects, and targeted treatment using ferroptosis drugs. The currently unresolved issues and future research directions for ferroptosis in tumor cells were discussed, along with the prospects of this emerging field.

CELL DEATH & DISEASE (2022)

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Article Oncology

The establishment of polypeptide PSMA-targeted chimeric antigen receptor-engineered natural killer cells for castration-resistant prostate cancer and the induction of ferroptosis-related cell death

Liyuan Wu et al.

Summary: A novel CAR-NK cell with a clinically significant tumoricidal effect on castration-resistant prostate cancer (CRPC) was designed and verified to have anti-tumor effects in vitro and in vivo.

CANCER COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-Based Synergistic Cancer Therapy

Yuzhi Xu et al.

Summary: Cuproptosis, a copper-dependent form of regulated cell death, offers great opportunities for cancer treatment. In this study, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], is developed for starvation-augmented cuproptosis and photodynamic synergistic therapy. In vivo experimental results show its effectiveness in inhibiting tumor growth.

ADVANCED MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

Xiaopei Hao et al.

Summary: This study demonstrates that inhibiting APOC1 can promote the transformation of M2 macrophages into M1 macrophages via the ferroptosis pathway, thereby reshaping the tumor immune microenvironment and improving the anti-PD1 immunotherapy for hepatocellular carcinoma (HCC).

REDOX BIOLOGY (2022)

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Article Materials Science, Biomaterials

Synergistic therapy for orthotopic gliomas via biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis

Mingting Zhu et al.

Summary: This study presents a novel therapeutic strategy for glioma treatment by combining sonodynamic therapy and ferroptosis. The developed nanoparticles selectively accumulate in tumors and increase reactive oxygen species levels while depleting glutathione, leading to the death of glioma cells. Additionally, noninvasive blood-brain barrier opening enhances the accumulation of nanoparticles and significantly reduces the size of gliomas.

BIOMATERIALS SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

Zuli Wang et al.

Summary: Ferroptosis is primarily caused by intracellular iron activity and lipid peroxidation, while LINC00618 promotes apoptosis and ferroptosis by regulating the levels of BAX, caspase-3, ROS, and iron. LSH and SLC7A11 also play crucial roles in this process.

MOLECULAR THERAPY (2021)

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Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

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Article Chemistry, Multidisciplinary

Complementing Cancer Photodynamic Therapy with Ferroptosis through Iron Oxide Loaded Porphyrin-Grafted Lipid Nanoparticles

Xiaolong Liang et al.

Summary: The study presents a theranostic nanoplatform based on Fe3O4@PGL NPs, which showed outstanding therapeutic effects against cancer cells through excellent self-assembling nature, high loading of porphyrins, and photodynamic effects.

ACS NANO (2021)

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Article Oncology

Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer

Ali Ghoochani et al.

Summary: The study found that mediators of ferroptosis are expressed in treatment-resistant prostate cancer, and treatment with ferroptosis inducers such as erastin and RSL3 can significantly reduce prostate cancer cell growth and migration, potentially serving as novel therapeutic strategies.

CANCER RESEARCH (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Article Oncology

Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer

Wenqing Tang et al.

Summary: A novel FR risk signature comprising eight genes was constructed, with high FR risk associated with poor prognosis and identified as an independent prognostic factor. High FR risk was closely linked to BC immunosuppression, but may not predict the efficacy of ICIs. Additionally, SQLE was established as a crucial cancer-promoting gene in BC.

BMC CANCER (2021)

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Article Oncology

KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma

Yingqiang Lu et al.

Summary: The study identified the essential role of KLF2 in suppressing the metastasis of ccRCC and its close correlation with GPX4. KLF2 deficiency is sufficient to inhibit ferroptosis and promote the migration and invasion of RCC cells. Reverting KLF2 expression decreased pulmonary metastatic lesions and prolonged life span of mice, while GPX4 overexpression reversed these properties, establishing a novel critical pathway for human ccRCC invasion and metastasis.

CANCER LETTERS (2021)

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Article Oncology

Photodynamic therapy induces human esophageal carcinoma cell pyroptosis by targeting the PKM2/caspase-8/caspase-3/GSDME axis

Lisha Li et al.

Summary: The study demonstrates that PDT can induce pyroptosis in esophageal squamous cell carcinoma (ESCC) through targeting the PKM2/caspase-8/caspase-3/GSDME axis. This is the first in-depth study of the specific mechanism underlying PKM2-mediated pyroptosis under PDT in ESCC and may have significant implications for the clinical application of PDT in ESCC.

CANCER LETTERS (2021)

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Review Biochemistry & Molecular Biology

Apoptosis - Fueling the oncogenic fire

Camila Castillo Ferrer et al.

Summary: Recent studies have shown that apoptosis, traditionally believed to suppress tumors, may paradoxically promote tumor growth and metastasis in some cases. This phenomenon may be achieved through various mechanisms, including the interaction of apoptotic cells with their microenvironment and the abnormal roles of apoptosis effectors.

FEBS JOURNAL (2021)

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Article Biotechnology & Applied Microbiology

Mechanism and Role of the Neuropeptide LGI1 Receptor ADAM23 in Regulating Biomarkers of Ferroptosis and Progression of Esophageal Cancer

Chen Chen et al.

Summary: This study identified a ceRNA network associated with ferroptosis in esophgeal squamous cell carcinoma (ESCC) and constructed an FPI scoring model reflecting the activity of the ferroptosis pathway. Results showed that low expression of ADAM23 and ARHGEF26-AS1, and high expression of miR-372-3p were correlated with poor prognosis in EC patients. Functionally, overexpression of ADAM23 and ARHGEF26-AS1, as well as inhibition of miR-372-3p, promoted ferroptosis and inhibited proliferation and migration of ESCC cells. Mechanistically, ARHGEF26-AS1 upregulated ADAM23 expression by competitively binding to miR-372-3p.

DISEASE MARKERS (2021)

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Article Oncology

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Yahui Ding et al.

Summary: This study identified a novel approach to treat TNBC by inducing ferroptosis through ubiquitination of GPX4 with the compound DMOCPTL, and revealed the role of GPX4 in regulating mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Furthermore, the prodrug Compound 13 showed promising anti-tumor effects in vivo with no apparent toxicity, suggesting its potential as a lead compound for developing effective anti-TNBC drugs.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Medicine, Research & Experimental

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Ruize Gao et al.

Summary: The study reveals the critical role of YAP/TAZ in suppressing ferroptosis and establishing Sorafenib resistance in hepatocellular carcinoma (HCC). This highlights YAP/TAZ-based rewiring strategies as potential approaches to overcome HCC therapy resistance. The findings provide new insights into improving the efficacy of current therapies in cancer treatment.

EMBO MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Ferroptosis Induction in Multiple Myeloma Cells Triggers DNA Methylation and Histone Modification Changes Associated with Cellular Senescence

Emilie Logie et al.

Summary: This study indicates that inducing ferroptosis and epigenetic reprogramming by RSL3 can sensitize MM1 multiple myeloma cells, regardless of their glucocorticoid-sensitivity status. Analysis revealed the formation of non-heme iron-histone complexes and altered expression of histone modifications associated with DNA repair and cellular senescence.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression

Meiheban Bazhabayi et al.

Summary: CircRNAs play an important role in regulating HER-2-positive breast cancer, with circGFRA1 identified as a key player. CircGFRA1 binds to miR-1228 through the ceRNA mechanism, thereby modulating the expression of AIFM2 and impacting the progression of HER-2-positive breast cancer. This study suggests that circGFRA1 could be a novel and promising treatment option for HER-2-positive breast cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells

Zeng Ye et al.

Summary: FBW7 acts as a tumor suppressor by targeting oncoproteins for degradation in pancreatic cancer, with decreased expression leading to destabilization and activation of pathways like ferroptosis and apoptosis which inhibit tumor growth, suggesting potential new strategies for comprehensive treatment of pancreatic cancer.

REDOX BIOLOGY (2021)

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Review Cell Biology

Characteristics and Biomarkers of Ferroptosis

Xin Chen et al.

Summary: The induction and consequences of regulated cell death (RCD) result in changes in gene and protein expression, biochemical pathways, cell morphology, and size. Among different forms of RCD, ferroptosis, driven by iron overload and lipid peroxidation, is implicated in various pathological conditions and diseases. The ferroptotic response can be fine-tuned through oxidative stress and antioxidant pathways, and a series of inducers or inhibitors have been developed targeting metabolism-related proteins.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

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Review Oncology

System Xc-: a key regulatory target of ferroptosis in cancer

Man-ru Liu et al.

Summary: Ferroptosis, a novel cell death modality regulated by suppressing System Xc(-), is implicated in preventing cancer progression and improving chemotherapy sensitivity. Overexpression of xCT in System Xc(-) is closely related to malignant growth and poor prognosis in tumors.

INVESTIGATIONAL NEW DRUGS (2021)

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Article

Ferroptosis Mediated by Lipid Reactive Oxygen Species: A Possible Causal Link of Neuroinflammation to Neurological Disorders

Ying Cheng et al.

Oxidative Medicine and Cellular Longevity (2021)

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Article Oncology

In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer

Zaid Hamdoon et al.

Summary: This study demonstrated the technical feasibility of using OCT to map tumor margins and monitor skin changes post-PDT, as well as optimize treatment efficacy. OCT images showed distinct microstructural differences between different skin tissues, providing valuable information for histological analysis of skin lesions.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Article Biochemistry & Molecular Biology

The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2

Chunjie Meng et al.

Summary: USP11 plays a critical role in stabilizing NRF2 through deubiquitination, thereby promoting cell proliferation and resistance to stress-induced cell death. Experimental evidence supports the high expression of USP11 in non-small cell lung cancer and its positive correlation with NRF2 expression.

ONCOGENE (2021)

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Article Biochemistry & Molecular Biology

Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation

Jialei Sun et al.

Summary: QSOX1 acts as a cellular prooxidant in HCC, sensitizing cells to oxidative stress by inhibiting NRF2. There is a negative correlation between QSOX1 and NRF2 expression in tumor tissues from HCC patients, and QSOX1 can enhance sorafenib-induced ferroptosis.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549

Shi-hua Deng et al.

Summary: The study revealed that miR-324-3p reversed cisplatin resistance in A549/DDP cells by targeting the GPX4 gene, while also enhancing sensitivity to cisplatin-induced ferroptosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot et al.

Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Oncology

The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study

Fangshi Xu et al.

Summary: SLC7A11 is significantly upregulated in renal cell carcinoma and its overexpression is associated with worse prognosis, affecting nucleotide, fatty acid, and amino acid metabolism. It suppresses antitumor immunity by reducing CD8+ T and NK cell abundances. SLC7A11's expression is weakly correlated with therapeutic responses of chemotherapy and targeted drugs.

CANCER MEDICINE (2021)

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Article Medicine, General & Internal

Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells

Yueqing Wang et al.

Summary: The study revealed that Circ_0007142 regulates the growth, apoptosis, and ferroptosis of CRC cells by modulating miR-874-3p and GDPD5. This suggests that Circ_0007142 may serve as a valuable marker for ferroptosis in CRC therapy.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma

Wenbin Huang et al.

Summary: ABCC5 is identified as a critical regulator and therapeutic target of acquired sorafenib resistance in HCC cells. Inhibition of ABCC5 expression decreases sorafenib resistance in HCC cells, and its activation is closely associated with the PI3K/AKT/NRF2 axis, regulating intracellular antioxidants and inhibiting ferroptosis. The findings suggest ABCC5 as a potential new regulator of ferroptosis in HCC cells.

NEOPLASIA (2021)

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Review Oncology

Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities

Peyman Tabnak et al.

Summary: Lung cancer is one of the most common and deadliest cancers worldwide. Research shows that ferroptosis can contribute to cell death in tumor cells, making it a promising strategy for lung cancer treatment. Understanding the molecular mechanisms of ferroptosis is crucial for future studies and potential therapeutic interventions.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

Qiujie Wang et al.

Summary: The study revealed that GSTZ1 enhances sorafenib-induced ferroptosis by inhibiting the NRF2/GPX4 axis in HCC cells, and the combination therapy of sorafenib and GPX4 inhibitor RSL3 may be a promising strategy in HCC treatment.

CELL DEATH & DISEASE (2021)

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Article Oncology

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Shanwen Chen et al.

Summary: The study identified a reciprocal regulation between xCT and the transsulfuration pathway, which presents a targetable metabolic vulnerability. CTH derived H2S increased the stability of xCT through persulfidation of OTU domain-containing ubiquitin aldehyde-binding protein 1 at cysteine 91. Treatment with AOAA and Erastin resulted in synthetic lethality both in vitro and in vivo, primarily through increased ferroptosis and apoptosis.

NEOPLASIA (2021)

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Article Oncology

Studies on the Mechanism of Alloimperatorin on the Proliferation and Apoptosis of HeLa Cells

Yingying Bai et al.

Summary: Alloimperatorin induces apoptosis of cervical cancer cells HeLa by affecting mitochondrial membrane potential and decreasing the expression of apoptotic proteins.

JOURNAL OF ONCOLOGY (2021)

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Article Oncology

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

Zheng Tang et al.

Summary: The study revealed that USP35 is highly expressed in lung cancer tissues and cells. Silencing USP35 helps promote ferroptosis in lung cancer cells and inhibits cell growth and tumor progression. Overexpression of USP35 leads to a reduction in iron disturbance and ferroptosis, thereby facilitating lung cancer cell growth and tumor progression.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer

Guoqing Zhu et al.

Summary: This study found that O-GlcNAcylation increases the sensitivity of HCC cells to ferroptosis through YAP/TFRC. This discovery provides a new basis for clinical therapeutic strategies for HCC patients.

CELL DEATH DISCOVERY (2021)

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Article Immunology

PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability

Ling Jin et al.

Summary: PAQR3 was found to be downregulated in ALL, suppressing cell proliferation and exacerbating ferroptosis in ALL cells.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Article Chemistry, Multidisciplinary

Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

Rundi Song et al.

Summary: Researchers have developed a immunotherapy method that enhances the immunogenicity of tumor cells by inducing ferroptosis, thereby improving the efficacy of cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

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Article Biochemistry & Molecular Biology

MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin

Dong Wei et al.

Summary: miR-302a-3p acts as a tumor inhibitor in non-small cell lung cancers by inducing ferroptosis. The miR-302a-3p mimic induces ferroptosis, while its inhibitor can block ferroptosis and tumor suppression.

FREE RADICAL RESEARCH (2021)

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Article Gastroenterology & Hepatology

IL-1β-Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up-regulating Programmed Death Ligand 1 and Colony-Stimulating Factor 1

Qin He et al.

Summary: SLC7A11 is involved in inflammation-induced HCC metastasis by promoting tumor-associated immune cell infiltration. Interrupting this oncogenic loop may offer a promising therapy strategy for inhibiting SLC7A11-mediated HCC metastasis.

HEPATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases

Xintong Wang et al.

Summary: Ferroptosis is a novel type of cell death caused by intracellular iron accumulation, leading to lipid peroxidation and cell death. The excessive iron concentration in the central nervous system is associated with oxidative stress, lipid peroxidation, and cell death. The hippocampus, an important brain region for cognitive functions, is sensitive to disruptions in iron homeostasis, which can contribute to neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression

Jing Wang et al.

Summary: In this study, it was found that CPEB1 promotes erastin-induced ferroptosis by inhibiting twist1. Overexpression of CPEB1 makes GC cells more sensitive to erastin, while silencing CPEB1 makes cells more resistant. This demonstrates the importance of CPEB1 in regulating ferroptosis in gastric cancer.

IUBMB LIFE (2021)

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Article Oncology

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

Jingjing Yang et al.

Summary: This study demonstrates that metformin induces ferroptosis in an AMPK-independent manner to suppress tumor growth. Mechanistically, metformin increases the intracellular Fe2+ and lipid ROS levels by targeting the UFMylation process of SLC7A11. Additionally, combining metformin with the x(c)(-) inhibitor sulfasalazine synergistically induces ferroptosis and inhibits the proliferation of breast cancer cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Medicine, Research & Experimental

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Lei Feng et al.

Summary: This study revealed a connection between high expression of SLC7A11 and nuclear expression of NRF2 in patients with ESCC, which was associated with worse survival rates and poorer treatment outcomes. SLC7A11-mediated ferroptosis inhibition induced NRF2-associated radioresistance.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma

Fengping Yao et al.

Summary: Iron regulatory protein IRP1 plays an essential role in ferroptosis induced by erastin and RSL3, regulating iron homeostasis and affecting the survival and death of melanoma cells.

ONCOLOGY LETTERS (2021)

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Article Multidisciplinary Sciences

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Daniel M. Kremer et al.

Summary: Cancer metabolism is rewired to support cell survival, with targeting metabolic dependencies following GOT1 inhibition leading to ferroptosis, an iron-dependent form of cell death. The study identifies a biochemical connection between GOT1, iron regulation, and ferroptosis in pancreatic cancer cells.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Wen Liu et al.

Summary: High cholesterol levels have been associated with increased risk of cancer, with cholesterol metabolite 27HC potentially leading to the generation of cancer cells resistant to ferroptosis, thereby promoting tumor growth and metastasis. These findings emphasize the significance of ferroptosis in tumor development and suggest that dyslipidemia/hypercholesterolemia impacts cancer pathogenesis by selecting for cells resistant to ferroptotic cell death.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Medicinal

Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4

Guan-Nan He et al.

Summary: Ketamine was found to suppress liver cancer cell proliferation and induce ferroptosis, potentially through regulating the lncPVT1/miR-214-3p/GPX4 axis.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Pharmacology & Pharmacy

Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer

Dan Sun et al.

Summary: Lidocaine has been shown to enhance ferroptosis and suppress cell proliferation, apoptosis, invasion, and migration in ovarian and breast cancer cells. By downregulating SLC7A11 expression through the miR-382-5p/SLC7A11 axis, lidocaine promotes ferroptosis in these cancer cells. Clinical studies are needed to further investigate the potential of lidocaine in treating ovarian and breast cancer.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy

Rui Sha et al.

Summary: This study identified ACSL4 and GPX4 as novel predictive and prognostic biomarkers for breast cancer patients receiving neoadjuvant chemotherapy. Higher ACSL4 expression was associated with better overall survival, while higher GPX4 expression was associated with better distant metastasis-free survival.

EBIOMEDICINE (2021)

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Article Cell Biology

Comprehensive Analysis of Ferroptosis Regulators With Regard to PD-L1 and Immune Infiltration in Clear Cell Renal Cell Carcinoma

Song Wang et al.

Summary: Our study revealed that ferroptosis regulators are correlated with the immune-related gene PD-L1 in clear cell renal cell carcinoma (ccRCC). Consensus clustering analysis identified two subtypes, with subtype 1 showing better prognosis and higher PD-L1 expression, while subtype 2 exhibited higher levels of immune cell infiltration. Enrichment analysis indicated significant pathways in subtype 1, suggesting their important role in ccRCC progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Oncology

Tumour fatty acid metabolism in the context of therapy resistance and obesity

Andrew J. Hoy et al.

Summary: This review discusses the mechanistic links between fatty acid metabolism in cancer cells and disease behavior and therapy resistance, emphasizing the importance of factors such as lipid synthesis, storage, and catabolism in supporting tumorigenesis and treatment resistance. The role of membrane fatty acid composition is increasingly appreciated for promoting cell survival and limiting lipotoxicity and ferroptosis, while tumor cells exhibit plasticity in response to metabolic signals, such as obesity and cancer therapeutics, to promote aggressive, treatment-resistant disease. The study also highlights the impact of obesity-associated changes in host fatty acid metabolism on the tumor microenvironment and cancer cell behavior.

NATURE REVIEWS CANCER (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc-

Liyuan Wang et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Cell Biology

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

Xuefei Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Gastroenterology & Hepatology

DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma

Bin Jiang et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

Ling F. Ye et al.

ACS CHEMICAL BIOLOGY (2020)

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Review Oncology

New aspects of amino acid metabolism in cancer

Lisa Vettore et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Cell Biology

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei et al.

CELL RESEARCH (2020)

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Article Cell Biology

MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells

Tao Bai et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Multidisciplinary Sciences

Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

Yongfei Yang et al.

NATURE COMMUNICATIONS (2020)

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Review Oncology

Ferroptosis in Cancer Cell Biology

Christina M. Bebber et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

The multifaceted role of reactive oxygen species in tumorigenesis

Anuradha Kirtonia et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Review Neurosciences

Iron Metabolism, Ferroptosis, and the Links With Alzheimer's Disease

Nao Yan et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

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Article Cell Biology

ACADSB regulates ferroptosis and affects the migration, invasion, and proliferation of colorectal cancer cells

Di Lu et al.

CELL BIOLOGY INTERNATIONAL (2020)

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Article Oncology

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

Li Yang et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Cell Biology

Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5

Zhiqian Liu et al.

CELL DEATH DISCOVERY (2020)

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Article Biochemistry & Molecular Biology

NEDD4L-mediated LTF protein degradation limits ferroptosis

Yuan Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Toll-like receptor 4 plays a key role in advanced glycation end products-induced M1 macrophage polarization

Zhongwei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Cell Biology

Emerging Mechanisms and Disease Relevance of Ferroptosis

Brent R. Stockwell et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Medicine, Research & Experimental

Identification of MiR-211-5p as a tumor suppressor by targeting ACSL4 in Hepatocellular Carcinoma

Xia Qin et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Lymph protects metastasizing melanoma cells from ferroptosis

Jessalyn M. Ubellacker et al.

NATURE (2020)

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Article Cell Biology

MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells

Chengcheng Gai et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer

Yueyue Yang et al.

CANCER CELL INTERNATIONAL (2020)

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Article Multidisciplinary Sciences

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

Enyong Dai et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

Corrin A. Wohlhieter et al.

CELL REPORTS (2020)

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Article Pharmacology & Pharmacy

The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

Yun Tsai et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Oncology

Targeting ferroptosis in breast cancer

Zhaoqing Li et al.

BIOMARKER RESEARCH (2020)

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Article Chemistry, Medicinal

Evaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer

Negar Dinarvand et al.

RESEARCH IN PHARMACEUTICAL SCIENCES (2020)

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Review Biochemistry & Molecular Biology

The interaction between ferroptosis and lipid metabolism in cancer

Dingshan Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

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Article Multidisciplinary Sciences

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Didac Carmona-Gutierrez et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages

Xiaorong Hu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Biochemistry & Molecular Biology

The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

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Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

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Article Cell Biology

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

Shiyao Sui et al.

CELL DEATH & DISEASE (2019)

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Review Biochemistry & Molecular Biology

Cisplatin: The first metal based anticancer drug

Sumit Ghosh

BIOORGANIC CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

Shu-Wing Ng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Multidisciplinary Sciences

Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling

Jiao Wu et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Clockophagy is a novel selective autophagy process favoring ferroptosis

Minghua Yang et al.

SCIENCE ADVANCES (2019)

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Editorial Material Cell Biology

Autophagic degradation of the circadian clock regulator promotes ferroptosis

Jiao Liu et al.

AUTOPHAGY (2019)

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Article Oncology

Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11

Xueting Lang et al.

CANCER DISCOVERY (2019)

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Article Cell Biology

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

Wen-Hsuan Yang et al.

CELL REPORTS (2019)

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Review Oncology

Iron and lung cancer

Yanbin Kuang et al.

CANCER LETTERS (2019)

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Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

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Review Cell Biology

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Multidisciplinary Sciences

Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers

Ahmed Gomaa et al.

SCIENTIFIC REPORTS (2019)

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Review Biochemistry & Molecular Biology

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

Daniel Frank et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Review Biochemistry & Molecular Biology

Iron Metabolism in Cancer

Yafang Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Yan Zhang et al.

CELL CHEMICAL BIOLOGY (2019)

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Review Oncology

YAP/TAZ Signaling and Resistance to Cancer Therapy

Chan D. K. Nguyen et al.

TRENDS IN CANCER (2019)

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Article Biochemistry & Molecular Biology

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Leslie Magtanong et al.

CELL CHEMICAL BIOLOGY (2019)

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Article Oncology

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis

Aadya Nagpal et al.

BREAST CANCER RESEARCH (2019)

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Article Oncology

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

Jennifer Tsoi et al.

CANCER CELL (2018)

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Article Oncology

Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma

Jingyuan Wang et al.

CANCER LETTERS (2018)

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Article Oncology

A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53

Chao Mao et al.

CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold et al.

CELL (2018)

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Review Chemistry, Medicinal

Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]-gingerol in cancer: A comprehensive review

Rosalia Maria Torres de Lima et al.

PHYTOTHERAPY RESEARCH (2018)

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Article Cell Biology

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

Amy Tarangelo et al.

CELL REPORTS (2018)

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Article Oncology

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway

Yun Zhou et al.

CANCER MEDICINE (2018)

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Letter Oncology

Oral Ketamine vs Placebo in Patients With Cancer-Related Neuropathic Pain: A Randomized Clinical Trial

Marie T. Fallon et al.

JAMA ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity

Xinxin Song et al.

CURRENT BIOLOGY (2018)

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Review Oncology

Tumor-Treating Fields: A Fourth Modality in Cancer Treatment

Elijah J. Mun et al.

CLINICAL CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

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Review Immunology

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

Si Ming Man et al.

IMMUNOLOGICAL REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Application of Chromatographic and Spectroscopic Methods towards the Quality Assessment of Ginger (Zingiber officinale) Rhizomes from Ecological Plantations

Wojciech Koch et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

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Article Chemistry, Medicinal

Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats

Feng Zhang et al.

PHYTOTHERAPY RESEARCH (2017)

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Article Oncology

Comparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell lines

Fabiola Rusolo et al.

ONCOLOGY LETTERS (2017)

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Article Cell Biology

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Yangchun Xie et al.

CELL REPORTS (2017)

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Article Oncology

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

Z. Fan et al.

ONCOGENESIS (2017)

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Review Pharmacology & Pharmacy

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer

Muthu K. Shanmugam et al.

CURRENT VASCULAR PHARMACOLOGY (2017)

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Article Nanoscience & Nanotechnology

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Sung Eun Kim et al.

NATURE NANOTECHNOLOGY (2016)

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Article Oncology

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

Masanori Hasegawa et al.

ONCOTARGET (2016)

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Article Cell Biology

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

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CELL REPORTS (2016)

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Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

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ACS CHEMICAL BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs

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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Immunology

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Mai Matsushita et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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Article Multidisciplinary Sciences

Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang et al.

NATURE (2015)

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Review Cell Biology

Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

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PROTEIN & CELL (2015)

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Editorial Material Medicine, General & Internal

Cancer nanomedicines: closing the translational gap

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LANCET (2014)

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Review Clinical Neurology

The role of iron in brain ageing and neurodegenerative disorders

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LANCET NEUROLOGY (2014)

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Article Biology

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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ELIFE (2014)

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Article Multidisciplinary Sciences

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

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NATURE (2013)

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Review Oncology

The Hippo pathway and human cancer

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NATURE REVIEWS CANCER (2013)

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Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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CELL (2012)

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Review Oncology

Update on the current indications, practice and results of photodynamic therapy (PDT) in early central lung cancer (ECLC)

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PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2008)

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Review Physiology

The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology

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PHYSIOLOGICAL REVIEWS (2007)

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Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

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Article Gastroenterology & Hepatology

Modulation of iron transport proteins in human colorectal carcinogenesis

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GUT (2006)

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