Characterization of a tetrameric proanthocyanidin in Stryphnodendron pulcherrimum and an overview on potential health benefits of condensed tannins via interaction with gut microbiota

Stryphnodendron pulcherrimum is a plant found in the Brazilian Amazon and contains high content of catechin/ (epi)catechin (flavan-3-ol) derivatives. The polymerization of this kind of flavan-3-ol generates condensed tannins, often associated to plant-based diets and gut microbiota. Thus, the discovery of condensed tannins from plants is a valuable approach once it enhances their availability from natural sources. Herein, we described a tetrameric condensed tannin (Molecular Mass 1,170 a.m.u.) tentatively identified for the first time in the barks from S. pulcherrimum. Condensed tannins-derived (flavan-3-ols units) are likely degraded in the gut, and their degradation products such as 3-hydroxyphenylacetic acid (OPAC), 3,4-dihydroxyphenylacetic acid (DHAA), 3(3,4-dihydroxyphenyl)-propionic acid (DHPA), and 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone (DHPV) could present benefits to gut microbiome metabolism. Therefore, this observational study represents a new insight into S. pulcherrimum, its molecules, and their potential benefits to avoid different diseases and gut well-functional.

Automated summary

This study explores the presence of high content of catechin/ (epi)catechin derivatives in Stryphnodendron pulcherrimum, a plant found in the Brazilian Amazon. The discovery of condensed tannins and their potential benefits to gut microbiome metabolism is highlighted. The study also identifies a new tetrameric condensed tannin and suggests its potential role in preventing diseases and maintaining gut well-function.