Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors

Article Oncology

Molecular profiling and target actionability for precision medicine in neuroendocrine neoplasms: real-world data

Alice Boileve et al.

Summary: Molecular profiling (MP) identified actionable molecular alterations in 48% of neuroendocrine neoplasms (NENs), with 35% of patients receiving molecularly matched treatment and a clinical benefit observed in 67% of cases.

EUROPEAN JOURNAL OF CANCER (2023)

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Article Oncology

Diagnostic performance of PET/CT in the detection of liver metastases in well-differentiated NETs

Freba Grawe et al.

Summary: This retrospective study aimed to compare the diagnostic accuracy of SSR-PET/CT and liver MRI in evaluating hepatic involvement in neuroendocrine tumors. The results showed that SSR-PET/CT has high sensitivity and specificity in identifying hepatic involvement, but potential pitfalls should be considered when evaluating neuroendocrine liver metastases using a single imaging method.

CANCER IMAGING (2023)

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Review Oncology

Tumour Heterogeneity and the Consequent Practical Challenges in the Management of Gastroenteropancreatic Neuroendocrine Neoplasms

Isabella Reccia et al.

Summary: Neuroendocrine neoplasms (NENs) are heterogeneous tumors that can have different disease courses and outcomes. Tumor heterogeneity is common in NENs and can affect treatment response and survival. This review summarizes the impact of tumor heterogeneity on the diagnosis and treatment of gastroenteropancreatic NENs.

CANCERS (2023)

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Article Oncology

Dual [68Ga]DOTATATE and [18F]FDG PET/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score

David L. Chan et al.

Summary: This study validates the NETPET score as a prognostic biomarker in metastatic GEPNENs, capturing the complexity of dual PET imaging.

BRITISH JOURNAL OF CANCER (2023)

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Article Oncology

Survival predictors of 177Lu-Dotatate peptide receptor radionuclide therapy (PRRT) in patients with progressive well-differentiated neuroendocrine tumors (NETS)

Mina M. Swiha et al.

Summary: Lu-177-Dotatate treatment outcomes are influenced by factors such as the presence of bone metastases, tumor type, and ascites occurrence. A high burden of skeletal and hepatic metastases and the existence of unusual metastatic locations negatively impact patient survival.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Value of [68Ga]Ga-somatostatin receptor PET/CT in the grading of pulmonary neuroendocrine (carcinoid) tumours and the detection of disseminated disease: single-centre pathology-based analysis and review of the literature

Anne-Leen Deleu et al.

Summary: This study retrospectively analyzed the value of SSTR PET/CT in pulmonary carcinoid tumors. The results showed that SSTR PET/CT has a high diagnostic value in differentiating TC from AC and detecting lymph node involvement and distant metastases of pulmonary carcinoids.

EJNMMI RESEARCH (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study

Vittoria Rufini et al.

Summary: This study found a good agreement between SSTR2-IHC and tumor uptake at SSTR-PET/CT in lung NETs, and SUVmax values can be used as a parameter of SSTR2 density.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

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Editorial Material Cell Biology