期刊
VIRUSES-BASEL
卷 15, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/v15091821
关键词
passive drool; Anelloviridae; Redondoviridae; Cressdnaviricota; Caudoviricetes; Microviridae; Inoviridae
类别
This study utilized metagenomic sequencing methods to explore the diversity of oral viruses in humans. The samples were collected from healthy individuals and various viruses, including coronaviruses, bacteriophages, and inoviruses, were identified. These findings expand our understanding of the diversity of oral viruses in North Carolina, USA.
The diversity of viruses identified from the various niches of the human oral cavity-from saliva to dental plaques to the surface of the tongue-has accelerated in the age of metagenomics. This rapid expansion demonstrates that our understanding of oral viral diversity is incomplete, with only a few studies utilizing passive drool collection in conjunction with metagenomic sequencing methods. For this pilot study, we obtained 14 samples from healthy staff members working at the Duke Lemur Center (Durham, NC, USA) to determine the viral diversity that can be identified in passive drool samples from humans. The complete genomes of 3 anelloviruses, 9 cressdnaviruses, 4 Caudoviricetes large bacteriophages, 29 microviruses, and 19 inoviruses were identified in this study using high-throughput sequencing and viral metagenomic workflows. The results presented here expand our understanding of the vertebrate-infecting and microbe-infecting viral diversity of the human oral virome in North Carolina (USA).
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