期刊
MULTIPLE SCLEROSIS JOURNAL
卷 22, 期 4, 页码 451-460出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458515622827
关键词
Metabolomics; multiple sclerosis; mass spectrometry; nuclear magnetic resonance; biomarkers
资金
- Institutional Clinician Training Award from the National Multiple Sclerosis Society
Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system with inflammatory and degenerative components. The cause of MS remains unknown although genetic and environmental factors appear to play a role in its etiopathogenesis. Metabolomics is a new omics technology that aims at measuring small molecules in various biological matrices and can provide information that is not readily obtained from genomics, transcriptomics, or proteomics. Currently, several different analytical platforms exist for metabolomics, and both untargeted and targeted approaches are being employed. Methods of analysis of metabolomics data are also being developed and no consensus currently exists on the optimal approach to analysis and interpretation of these data. Metabolomics has the potential to provide putative biomarkers, insights into the pathophysiology of the disease, and to aid in precision medicine for patients with MS.
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