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ONCOLOGY LETTERS (2014)
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Nikolai Slavov et al.
CELL REPORTS (2014)
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
Alden C. Klarer et al.
CANCER & METABOLISM (2014)
Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane
Tamir Epstein et al.
CANCER & METABOLISM (2014)
Mitochondria-Mediated Energy Adaption in Cancer: The H+-ATP Synthase-Geared Switch of Metabolism in Human Tumors
Maria Sanchez-Arago et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells
J. Xin et al.
BIOMEDICINE & PHARMACOTHERAPY (2013)
ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo
Jing Xin et al.
CANCER LETTERS (2013)
Molecular Pathways: Fumarate Hydratase-Deficient Kidney Cancer-Targeting the Warburg Effect in Cancer
W. Marston Linehan et al.
CLINICAL CANCER RESEARCH (2013)
Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target
Hoon Hur et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
The SLC16 gene family - Structure, role and regulation in health and disease
Andrew P. Halestrap
MOLECULAR ASPECTS OF MEDICINE (2013)
Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo
Xianbin Cai et al.
ONCOLOGY REPORTS (2013)
The novel BH-3 mimetic apogossypolone induces Beclin-1-and ROS-mediated autophagy in human hepatocellular cells
P. Cheng et al.
CELL DEATH & DISEASE (2013)
Targeting cellular metabolism to improve cancer therapeutics
Y. Zhao et al.
CELL DEATH & DISEASE (2013)
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells
Y. Yuan et al.
CELL DEATH & DISEASE (2013)
Understanding mitochondrial complex I assembly in health and disease
Masakazu Mimaki et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2012)
NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain
Eduardo Balsa et al.
CELL METABOLISM (2012)
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
Anne Le et al.
CELL METABOLISM (2012)
Low expression of prolyl hydroxylase 2 is associated with tumor grade and poor prognosis in patients with colorectal cancer
Ganfeng Xie et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2012)
A translational study case report on the small molecule energy blocker 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
Y. H. Ko et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2012)
Gastric Leiomyoma and Hyperplastic Polyposis Coli in a Patient with Multiple Cutaneous and Uterine Leiomyomatosis
David Serra et al.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY (2012)
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice
Femke Heindryckx et al.
JOURNAL OF HEPATOLOGY (2012)
The Antidiabetic Drug Metformin Inhibits Gastric Cancer Cell Proliferation In Vitro and In Vivo
Kiyohito Kato et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Altered expression of mitochondrial cytochrome c oxidase I and NADH dehydrogenase 4 transcripts associated with gastric tumorigenesis and tumor dedifferentiation
Jie-Tao Ma et al.
MOLECULAR MEDICINE REPORTS (2012)
Enhancement of cytotoxic and pro-apoptotic effects of 2-aminophenoxazine-3-one on the rat hepatocellular carcinoma cell line dRLh-84, the human hepatocellular carcinoma cell line HepG2, and the rat normal hepatocellular cell line RLN-10 in combination with 2-deoxy-D-glucose
Akira Takemura et al.
ONCOLOGY REPORTS (2012)
Prolyl Hydroxylase Domain 2 Protein Is a Strong Prognostic Marker in Human Gastric Cancer
Carsten Kamphues et al.
PATHOBIOLOGY (2012)
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
Pierre Sonveaux et al.
PLOS ONE (2012)
Pan-Bcl-2 Inhibitor AT-101 Enhances Tumor Cell Killing by EGFR Targeted T Cells
Archana Thakur et al.
PLOS ONE (2012)
Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells
Christophe J. De Saedeleer et al.
PLOS ONE (2012)
Cancer metabolism: current perspectives and future directions
C. Munoz-Pinedo et al.
CELL DEATH & DISEASE (2012)
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Sophia Y. Lunt et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer
G. R. Gunassekaran et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Metabolic Flux and the Regulation of Mammalian Cell Growth
Jason W. Locasale et al.
CELL METABOLISM (2011)
Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo
Zuzana Zachar et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2011)
Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1
Ying Wang et al.
MOLECULAR ENDOCRINOLOGY (2011)
Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
E. Babu et al.
ONCOGENE (2011)
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
Renaud Le Floch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells
Nie Yingkun et al.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2010)
Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2
Z. X. Chen et al.
CELL DEATH AND DIFFERENTIATION (2010)
Expression of key hypoxia sensing prolyl-hydroxylases PHD1,-2 and-3 in pancreaticobiliary cancer
Lucy Gossage et al.
HISTOPATHOLOGY (2010)
SDHA is a tumor suppressor gene causing paraganglioma
Nelly Burnichon et al.
HUMAN MOLECULAR GENETICS (2010)
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Anne Le et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors
A. M. Schmitt et al.
ENDOCRINE-RELATED CANCER (2009)
Mitochondrial DNA Instability and Metabolic Shift in Human Cancers
Hsin-Chen Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2009)
A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase
Ida Namslauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
CYP2D6 and tamoxifen: DNA matters in breast cancer
Janelle M. Hoskins et al.
NATURE REVIEWS CANCER (2009)
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
E. D. Michelakis et al.
BRITISH JOURNAL OF CANCER (2008)
Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model
Xianhua Cao et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2008)
Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis
Qiang Zhang et al.
FOOD AND CHEMICAL TOXICOLOGY (2008)
3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs
Linda Strandberg Ihrlund et al.
MOLECULAR ONCOLOGY (2008)
Metformin induces apoptosis of pancreatic cancer cells
Luo-Wei Wang et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence
Harald Hoensch et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Ralph J. DeBerardinis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Identification of mitochondrial FoF1-ATP synthase involved in liver metastasis of colorectal cancer
Hee Jin Chang et al.
CANCER SCIENCE (2007)
Oxygen metabolism and a potential role for cytochrome c oxidase in the Warburg effect
Paul C. Herrmann et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)
Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
Michael B. Ujiki et al.
MOLECULAR CANCER (2006)
Adult Leydig cell tumors of the testis caused by germline fumarate hydratase mutations
Luis G. Carvajal-Carmona et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells
Lien-Chai Chiang et al.
CANCER LETTERS (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission
LC Greaves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
Valeria R. Fantin et al.
CANCER CELL (2006)
Suppression of hypoxia-inducible factor 1α (HIF-1α) transcriptional activity by the HIF prolyl hydroxylase EGLN1
KKW To et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line
RM Mohammad et al.
PANCREAS (2005)
Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells
Kun Wu et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2005)
Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression
JC Maher et al.
PANCREAS (2005)
Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma:: Association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1α
T Kuwai et al.
CANCER SCIENCE (2004)
Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells
ZL Yu et al.
CANCER LETTERS (2004)
Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression
P Buchler et al.
CANCER (2004)
Potentiation of antiproliferative drug activity by lonidamine in hepatocellular carcinoma cells
L Ricotti et al.
JOURNAL OF CHEMOTHERAPY (2003)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
E Berra et al.
EMBO JOURNAL (2003)
High-dose tamoxifen in the treatment of inoperable hepatocellular carcinoma: A multicenter randomized controlled trial
PKH Chow et al.
HEPATOLOGY (2002)
Apigenin -: strong cytostatic in vitro contrasted by lack of and anti-angiogenic action efficacy in vivo
C Engelmann et al.
PHYTOMEDICINE (2002)
Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome c release and apoptosis
M Mouria et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
IPM Tomlinson et al.
NATURE GENETICS (2002)
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
D Astuti et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Mutations in SDHC cause autosomal dominant paraganglioma, type 3
S Niemann et al.
NATURE GENETICS (2000)
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
M Ohh et al.
NATURE CELL BIOLOGY (2000)
Phase II trial of low-dose cyclophosphamide, leucovorin, high-dose 5-fluorouracil 24-hour continuous infusion and tamoxifen in advanced biliary tract cancer
F Eckel et al.
ANNALS OF ONCOLOGY (2000)
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
BE Baysal et al.
SCIENCE (2000)
Hypoxia induces hexokinase II gene expression in human lung cell line A549
SR Riddle et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)
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