期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 29, 期 25, 页码 3964-3983出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v29.i25.3964
关键词
Hepatitis B; Therapy; Antigen; Functional cure; Antiviral agents; Drug development
The estimated global prevalence of HBV infection is about 316 million. Despite universal vaccination programs and effective antiviral therapy, HBV infection remains a major cause of cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (NA) have been the preferred treatment for chronic hepatitis B for many years, but the low probability of HBV surface antigen seroclearance requires indefinite treatment. Recent advances in understanding the viral cycle and the role of the immune system have led to the development of new therapeutic approaches and ongoing clinical trials with promising results.
The estimated world prevalence of hepatitis B virus (HBV) infection is 316 million. HBV infection was identified in 1963 and nowadays is a major cause of cirrhosis and hepatocellular carcinoma (HCC) despite universal vaccination programs, and effective antiviral therapy. Long-term administration of nucleos(t)ide analogues (NA) has been the treatment of choice for chronic hepatitis B during the last decades. The NA has shown a good safety profile and high efficacy in controlling viral replication, improving histology, and decreasing the HCC incidence, decompensation, and mortality. However, the low probability of HBV surface antigen seroclearance made necessary an indefinite treatment. The knowledge, in recent years, about the different phases of the viral cycle, and the new insights into the role of the immune system have yielded an increase in new therapeutic approaches. Consequently, several clinical trials evaluating combinations of new drugs with different mechanisms of action are ongoing with promising results. This integrative literature review aims to assess the knowledge and major advances from the past of hepatitis B, the present of NA treatment and withdrawal, and the future perspectives with combined molecules to achieve a functional cure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据