☆ 4.6 Review

Serum resistin and the risk for hepatocellular carcinoma in diabetic patients

WORLD JOURNAL OF GASTROENTEROLOGY (2023)

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Review Gastroenterology & Hepatology

NAFLD-related hepatocellular carcinoma: The growing challenge

Pir Ahmad Shah et al.

Summary: Hepatocellular carcinoma (HCC) related to non-alcoholic fatty liver disease (NAFLD) is a common cause of cancer-related mortality and morbidity worldwide. The burden of NAFLD-related HCC is exponentially increasing due to the obesity pandemic. Cirrhosis is a major risk factor for NAFLD-related HCC, but it is increasingly recognized that patients without cirrhosis can also develop NAFLD-related HCC, posing a significant challenge for cancer surveillance. Therefore, developing optimal risk stratification scores and models to identify high-risk populations for surveillance is of paramount importance.

HEPATOLOGY (2023)

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Article Endocrinology & Metabolism

Estimates and trends of the global burden of NASH-related liver cancer attributable to high fasting plasma glucose in 1990-2019: analysis of data from the 2019 Global Burden of Disease Study

Ziyi Li et al.

Summary: The burden of NASH-related liver cancer attributable to high fasting plasma glucose (HFPG) has increased over the past three decades, particularly in regions with high and low sociodemographic index (SDI).

DIABETOLOGY & METABOLIC SYNDROME (2023)

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Editorial Material Oncology

Prioritized Requirements for First-Line Systemic Therapy for Hepatocellular Carcinoma: Broad Benefit with Less Toxicity

Masatoshi Kudo

LIVER CANCER (2023)

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Article Gastroenterology & Hepatology

TRIM27-USP7 complex promotes tumour progression via STAT3 activation in human hepatocellular carcinoma

Toshiya Sakamoto et al.

Summary: The complex of TRIM27 and USP7 plays a role in activating STAT3, which promotes aggressive tumor progression and poor prognosis in hepatocellular carcinoma (HCC).

LIVER INTERNATIONAL (2023)

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Article Oncology

CFDP1 promotes hepatocellular carcinoma progression through activating NEDD4/PTEN/PI3K/AKT signaling pathway

Yan Zhou et al.

Summary: This study found that CFDP1 is highly expressed in hepatocellular carcinoma (HCC) and is positively correlated with adverse clinicopathological features. Overexpression of CFDP1 is associated with lower recurrence-free survival and overall survival. Furthermore, CFDP1 enhances the malignancy of HCC through the NEDD4-mediated PTEN/PI3K/AKT pathway.

CANCER MEDICINE (2023)

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Review Gastroenterology & Hepatology

Development and prognosis of hepatocellular carcinoma in patients with diabetes

Takuma Nakatsuka et al.

Summary: The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been increasing worldwide due to obesity and non-alcoholic fatty liver disease (NAFLD). Diabetes increases the risk of developing HCC, and vice versa. The interconnections among diabetes, obesity, and NAFLD are the underlying causes of hepatocarcinogenesis in diabetic patients. Further research on antidiabetic drugs for hepatoprotection is needed. It is important for diabetologists and hepatologists to work together to address this emerging health issue. (Clin Mol Hepatol 2023;29:51-64)

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma incidence is decreasing in Korea but increasing in the very elderly

Young Eun Chon et al.

Summary: This study analyzed the trends in hepatocellular carcinoma (HCC) incidence in South Korea over 10 years and predicted an increase in HCC incidence among elderly individuals in 2028.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

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Editorial Material Oncology

ASO Author Reflections: Effect of Preoperative Metabolic Syndrome for Patients with Hepatocellular Carcinoma

Ming-Da Wang et al.

ANNALS OF SURGICAL ONCOLOGY (2023)

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Review Gastroenterology & Hepatology

Role of Transarterial Chemoembolization in the Treatment of Hepatocellular Carcinoma

Bin-Yan Zhong et al.

Summary: This review article by experts from the Chinese Liver Cancer Clinical Study Alliance (CHANCE) summarizes the clinical evidence on the current application of TACE in patients with early-, intermediate-, and advanced-stage HCC. It also evaluates the combination of TACE with other treatment modalities, especially immunotherapy.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2023)

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Review Pharmacology & Pharmacy

Recent evaluation about inflammatory mechanisms in nonalcoholic fatty liver disease

Chong Song et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic metabolic liver disorder characterized by fat accumulation in the liver. Inflammation is a significant mechanism that can lead to cell death and tissue injury in NAFLD. Inhibition of inflammation improves NAFLD by reducing fat content, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- gamma (PPAR-gamma), and increasing insulin sensitivity. Understanding the molecular mechanisms and signaling pathways in NAFLD is crucial for its prevention and treatment.

FRONTIERS IN PHARMACOLOGY (2023)

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Review Cell Biology

Resistin-like molecules: a marker, mediator and therapeutic target for multiple diseases

Yaning Shi et al.

Summary: RELMs are highly cysteine-rich proteins, including RELM alpha, RELM beta, Resistin, and RELM gamma, which exhibit significant differences in structure, distribution, and function. The expression of RELMs is regulated by various signaling molecules, such as IL-4, IL-13, and their receptors. RELMs proteins are involved in a wide range of physiological and pathological processes, and participate in the progression of numerous diseases. Meanwhile, RELMs can serve as biomarkers, risk predictors, and therapeutic targets for these diseases, providing novel targets or strategies for their treatment and prevention.

CELL COMMUNICATION AND SIGNALING (2023)

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Editorial Material Gastroenterology & Hepatology

The latest global burden of liver cancer: A past and present threat

Joo Hyun Oh et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

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Meeting Abstract Oncology

Resistin mediates the immunoediting activity exerted by primary human macrophages towards mesothelioma cells

Malik Hamaidia et al.

CANCER RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

Hai-Dong Zhu et al.

Summary: There is significant potential for combining transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC). A nationwide retrospective cohort study found that TACE plus PD-(L)1 inhibitors and MTT could significantly improve progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) compared to TACE monotherapy in Chinese patients with predominantly advanced HCC in real-world practice.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Article Endocrinology & Metabolism

Hyperglycaemia-induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS-mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein

Tehreem Maradagi et al.

Summary: The study found that lutein can significantly block glucose-promoted HepG2 cell proliferation without inducing apoptosis. Lutein inhibits high glucose-induced proliferation by suppressing elevated ROS levels and upregulated expression of HO1, as well as modulating the phosphorylation of key proteins involved in cell cycle regulation.

DIABETIC MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

Dose-Response Associations of Metabolic Score for Insulin Resistance Index with Nonalcoholic Fatty Liver Disease among a Nonobese Chinese Population: Retrospective Evidence from a Population-Based Cohort Study

Xintian Cai et al.

Summary: This study investigated the association between the metabolic score for insulin resistance (METS-IR) index and nonalcoholic fatty liver disease (NAFLD) in the nonobese population and its predictive value. The results showed that elevated METS-IR was independently associated with an increased risk of NAFLD development, and there was a dose-response relationship. METS-IR may be a reliable indicator for screening individuals at risk for early NAFLD in nonobese populations.

DISEASE MARKERS (2022)

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Review Medicine, General & Internal

Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis

Sara Guerra et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) and its more severe form NASH are common complications in patients with obesity and type 2 diabetes. Understanding the pathogenesis and factors influencing the development of fatty liver disease can help in early identification and prevention of these serious conditions.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Gastroenterology & Hepatology

Effect of diabetes medications and glycemic control on risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease

Jennifer R. Kramer et al.

Summary: Patients with NAFLD and diabetes have a high risk of developing HCC. The study found that the use of metformin was associated with a reduced risk of developing HCC, while combination therapy was associated with an increased risk. Glycemic control can be a useful biomarker for stratifying HCC risk in these patients.

HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma

Camille Peneau et al.

Summary: This study aimed to characterize HBV integrations in liver tissues of HCC patients and revealed new mechanisms of HBV-associated oncogenesis. HBV integrations have direct oncogenic consequences, posing a challenge for the monitoring of HBV-infected patients.

GUT (2022)

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Review Gastroenterology & Hepatology

Risk of hepatocellular carcinoma after hepatitis C virus cure

Maria Alejandra Luna-Cuadros et al.

Summary: Hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC) and the introduction of direct-acting antivirals has revolutionized HCV therapy. Successful treatment greatly reduces the risk of HCC, but certain patients, especially those with cirrhosis, remain at risk even after achieving sustained virologic response (SVR). Noninvasive modalities and various fibrosis scores may be used to monitor hepatic fibrosis and predict the risk of HCC in patients with SVR, but further validation and standardization are needed before implementing them in routine clinical care.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

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Article Microbiology

Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients

Momen Askoura et al.

Summary: This study investigated the role of IL-33, IL-17, and IL-25 in patients with hepatitis C virus (HCV) and the progression of the disease from chronicity to hepatocellular carcinoma. The results showed that the serum levels of IL-33 and IL-17 significantly increased in patients with chronic hepatitis C and hepatocellular carcinoma. IL-33 was also found to be associated with liver fibrosis progression and viral load, while IL-17 and IL-25 were mainly related to the development of hepatocellular carcinoma.

PATHOGENS (2022)

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Article Rheumatology

Resistin induces chemokine and matrix metalloproteinase production via CAP1 receptor and activation of p38-MAPK and NF-κB signalling pathways in human chondrocytes

Cheng-Wu Zhao et al.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2022)

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Review Gastroenterology & Hepatology

Diabetes medications and risk of HCC

Maria Corina Plaz Torres et al.

Summary: Type 2 diabetes mellitus is a recognized risk factor for HCC in patients with liver disease, and the choice of diabetic medication in these patients can have complex implications for potential hepatic carcinogenesis. Metformin may reduce the risk of HCC, while evidence for other diabetic medications, especially newer agents, is limited and inconsistent. Further research is needed to understand the potential effects of different diabetic agents on liver cancer tumorigenesis.

HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Asian perspective on NAFLD-associated HCC

Terry Cheuk-Fung Yip et al.

Summary: Recent data shows that non-alcoholic fatty liver disease (NAFLD) has become a significant public health issue in Asia, with a population prevalence of 34%. The rising trend of NAFLD also leads to an increase in NAFLD-associated hepatocellular carcinoma (HCC). This review focuses on the changing epidemiology of HCC in Asia over the past 30 years, highlighting the importance of traditional risk factors and specific genetic polymorphism in East Asia. Additionally, non-obese individuals with NAFLD are commonly observed in Asia.

JOURNAL OF HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Maria Reig et al.

Summary: There have been significant advances in the treatment strategies for hepatocellular carcinoma since the last update in 2018. However, some interventions still lack sufficient data for clinical incorporation, and personalized clinical management requires consideration of multiple parameters.

JOURNAL OF HEPATOLOGY (2022)

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Article Medicine, Research & Experimental

A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis

Takafumi Sakuma et al.

Summary: The study establishes a new murine model of non-alcoholic fatty liver disease (NAFLD) with the presence of obesity and insulin resistance, which rapidly develops into steatohepatitis and fibrosis. This model could serve as a useful preclinical model for drug development in NAFLD.

LABORATORY INVESTIGATION (2022)

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Review Oncology

Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis

Darren Jun Hao Tan et al.

Summary: Compared with hepatocellular carcinoma due to other causes, patients with NAFLD-related hepatocellular carcinoma are older, have higher BMI, and are more likely to have metabolic comorbidities and cardiovascular disease. The surveillance rate is lower, but the proportion of patients without cirrhosis is higher.

LANCET ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer

Klaudia Parafiniuk et al.

Summary: The relationship between obesity and epithelial ovarian cancer (EOC) remains inconclusive. The adipokine hypothesis suggests that adipocytes in obese individuals interact with cancer cells and promote their migration and metastasis through the secretion of adipokines, growth factors, and hormones. Resistin, one of the adipokines, has been found to stimulate the growth and differentiation of ovarian cancer cells, increase angiogenesis factors, induce epithelial-mesenchymal transition (EMT), and affect survival in EOC patients.

BIOMEDICINES (2022)

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Article Gastroenterology & Hepatology

Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals

Chiara Saponaro et al.

Summary: This study investigates the association between visceral fat and subcutaneous fat with the severity of NAFLD, suggesting that visceral fat accumulation is a major risk factor for NAFLD.

LIVER INTERNATIONAL (2022)

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Review Gastroenterology & Hepatology

Impact of diabetes, obesity, and dyslipidemia on the risk of hepatocellular carcinoma in patients with chronic liver diseases

Hwang Sik Shin et al.

Summary: This review comprehensively summarizes the relationship between metabolic factors such as diabetes mellitus, obesity, and blood lipids and the risk of hepatocellular carcinoma (HCC) in patients with chronic liver diseases. Diabetes consistently increases the risk of HCC in patients with chronic liver disease, while obesity may also increase the risk. In terms of blood lipids, total cholesterol, low-density lipoprotein cholesterol, and triglyceride have strong inverse associations with HCC in individuals with chronic liver diseases.

CLINICAL AND MOLECULAR HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Global burden of primary liver cancer in 2020 and predictions to 2040

Harriet Rumgay et al.

Summary: The burden of liver cancer varies across the world, and it is a major cause of death in many countries. The number of liver cancer cases and deaths is predicted to increase, with a significant rise expected by 2040.

JOURNAL OF HEPATOLOGY (2022)

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Review Oncology

How Far beyond Diabetes Can the Benefits of Glucagon-like Peptide-1 Receptor Agonists Go? A Review of the Evidence on Their Effects on Hepatocellular Carcinoma

Konstantinos Arvanitakis et al.

Summary: GLP-1 receptor agonists may play a significant role in the treatment of hepatocellular carcinoma by regulating molecular pathways involved in inflammation, tumor cell proliferation, and oxidative stress. However, further studies are needed to evaluate the risk-to-benefit ratio of using GLP-1 receptor agonists in patients with HCC.

CANCERS (2022)

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Article Gastroenterology & Hepatology

NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population

Claire E. Thomas et al.

Summary: Using data from the Singapore Chinese Health Study (SCHS), researchers found a strong correlation between a polygenic risk score (PRS) for hepatic fat (HFC-PRS) and nonalcoholic fatty liver disease (NAFLD), as well as an increased risk of hepatocellular carcinoma (HCC).

HEPATOLOGY COMMUNICATIONS (2022)

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Article Gastroenterology & Hepatology

KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease

Seong Hee Kang et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2021)

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Review Oncology

The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review

Matthias Pinter et al.

Summary: Recent advancements in the treatment of advanced hepatocellular carcinoma (HCC) have led to the approval of new systemic therapies such as angiogenesis inhibitors and immune checkpoint blockers, indicating important progress in the field. Strategies to target immunosuppression in tumors, such as vascular endothelial growth factor pathway inhibition and transforming growth factor-beta pathway inhibition, show promise in enhancing the efficacy of immunotherapy in HCC. Successes and failures of these treatments have provided insights into implementing novel systemic therapy in HCC and improving immunotherapy efficacy for this disease.

JAMA ONCOLOGY (2021)

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Review Endocrinology & Metabolism

Metabolic Consequences of Solid Organ Transplantation

Mamatha Bhat et al.

Summary: Metabolic complications are common in solid organ transplant recipients, including posttransplant diabetes, nonalcoholic fatty liver disease, dyslipidemia, and obesity, impacting both graft and patient survival. Immunosuppression and posttransplant weight gain exacerbate preexisting metabolic diseases. Current evidence supports the importance of prevention and therapeutic management for these complications, while highlighting gaps in translational research for future exploration.

ENDOCRINE REVIEWS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Resistin: A journey from metabolism to cancer

Ankita Deb et al.

Summary: Resistin, a small secretory molecule, is implicated in insulin resistance development under obese conditions. It is associated with metabolic disorders, cardiovascular diseases, and cancers. Studies suggest it plays a pivotal role in cancer cell proliferation, metastasis, inflammation, and metabolism.

TRANSLATIONAL ONCOLOGY (2021)

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Review Oncology

Mechanisms Underlying Hepatocellular Carcinoma Progression in Patients with Type 2 Diabetes

Tingting Shi et al.

Summary: T2DM is a strong additive metabolic risk factor for HCC, increasing the risk of developing liver cancer and bile duct cancer in patients with T2DM. Evidence suggests that reducing obesity, diabetes, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis through efficient prevention measures may lead to decreased rates of T2DM-related HCC.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Oncology

Association between Lipid Profiles and the Incidence of Hepatocellular Carcinoma: A Nationwide Population-Based Study

Yuri Cho et al.

Summary: Cholesterol plays a crucial role in cell structure and proliferation, with altered lipid metabolism linked to hepatocellular carcinoma (HCC) development. A large-scale study in Korea found that low lipid levels were significantly associated with an increased risk of developing HCC, serving as both an independent risk factor and preclinical marker for the disease.

CANCERS (2021)

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Review Oncology

Hepatocellular Carcinoma: An Overview of the Changing Landscape of Treatment Options

Andreas Koulouris et al.

Summary: In recent years, there has been significant progress in understanding predisposing factors and improving treatment options for hepatocellular carcinoma (HCC). Traditional chemotherapy has been replaced by targeted therapies like TKIs and immunotherapies as the standard of care for HCC patients. Newer agents such as atezolizumab plus bevacizumab for first-line treatment and novel anti-angiogenic factors for second-line treatment are showing promising results in clinical trials.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

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Review Oncology

Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs

Ahmed Olatunde et al.

Summary: Cancer management often involves chemotherapy, surgery, and radiotherapy, but chemotherapy can be cytotoxic to normal cells and lead to drug resistance. Antidiabetic drugs such as sulfonylureas, biguanides, and thiazolidinediones have shown beneficial effects in cancer treatment, despite potential risks like pancreatic cancer development.

CANCER CELL INTERNATIONAL (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, Research & Experimental

Evolution of systemic treatment for advanced hepatocellular carcinoma

Tsung-Che Wu et al.

Summary: Over the past 20 years, systemic therapy for advanced hepatocellular carcinoma has evolved from traditional chemotherapy to molecular targeted therapy and immunotherapy targeting tumor angiogenesis or tumor immunity. The recent combination therapy of atezolizumab and bevacizumab has shown improved efficacy in treating advanced HCC without significant toxicities or negative impact on quality of life.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

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Editorial Material Medicine, General & Internal

Hepatocellular Carcinoma - Origins and Outcomes

Robin K. Kelley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Manoja K. Brahma et al.

Summary: Obesity is a well-established risk factor for hepatocellular carcinoma, with oxidative stress playing a key role in the initiation and progression of liver cancer. Excessive levels of reactive oxygen species (ROS) from fatty acid influx and chronic inflammation are major contributors to HCC progression. Dysregulated activity of BCL-2 proteins and protein tyrosine phosphatases (PTPs) are implicated in hepatic oxidative stress and dysfunctional signaling mediated by ROS.

ONCOGENE (2021)

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Review Oncology

An Update on Hepatocellular Carcinoma in Chronic Kidney Disease

Fabrizio Fabrizi et al.

Summary: Chronic kidney disease is a major public health issue globally and patients with chronic kidney disease have a higher risk of hepatocellular cancer. Viral hepatitis is a well-known cause of HCC, particularly in CKD population. Treatment options include liver transplant, local approach, and tyrosine kinase inhibitors.

CANCERS (2021)

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Review Gastroenterology & Hepatology

Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Dongli Han et al.

Summary: This study comprehensively investigated serum resistin levels in adult patients with NAFLD. The findings suggest that patients with NAFLD have higher serum resistin levels, while patients with NASH have lower serum resistin levels compared to healthy controls. Serum resistin could potentially serve as a biomarker for predicting the risk of developing NAFLD.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review

Victor Cunha et al.

ANNALS OF HEPATOLOGY (2020)

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Article Oncology

Higher cholesterol levels, not statin use, are associated with a lower risk of hepatocellular carcinoma

Sang-Wook Yi et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Gastroenterology & Hepatology

AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease: Expert Review

Rohit Loomba et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Non-enhanced magnetic resonance imaging as a surveillance tool for hepatocellular carcinoma: Comparison with ultrasound

Hyo Jung Park et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Global Burden of 5 Major Types of Gastrointestinal Cancer

Melina Arnold et al.

GASTROENTEROLOGY (2020)

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Review Oncology

Statin Use and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies

Md. Mohaimenul Islam et al.

CANCERS (2020)

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Review Cell Biology

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

Justin Hou Ming Yung et al.

CELLS (2020)

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Article Public, Environmental & Occupational Health

Risk of hepatocellular carcinoma in individuals without traditional risk factors: development and validation of a novel risk score

Dong Hyun Sinn et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)

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Review Oncology

Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies

Monica Mossenta et al.

CANCERS (2020)

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Review Cell Biology

Hepatic Stellate Cells and Hepatocarcinogenesis

Anna E. Barry et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Resistin: An inflammatory cytokine with multi-faceted roles in cancer

Sarabjeet Kour Sudan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Article Oncology

Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)

Jian Zhou et al.

LIVER CANCER (2020)

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Review Oncology

Hyperinsulinaemia in cancer

Emily J. Gallagher et al.

NATURE REVIEWS CANCER (2020)

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Article Biochemistry & Molecular Biology

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer

Yan Zheng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Gastroenterology & Hepatology

Non-alcoholic Fatty Liver Disease: Growing Burden, Adverse Outcomes and Associations

Ramesh Kumar et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Hyperlipidemia and Nonalcoholic Steatohepatitis Predispose to Hepatocellular Carcinoma Development Without Cirrhosis

Jennifer Phan et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2019)

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Article Biochemistry & Molecular Biology

Increased risk of hepatitis B virus infection amongst individuals with diabetes mellitus

Xuan Zhang et al.

BIOSCIENCE REPORTS (2019)

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Article Multidisciplinary Sciences

Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals

Livia Melo Villar et al.

PLOS ONE (2019)

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Article Gastroenterology & Hepatology

Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes

Karl Bjorkstrom et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Meeting Abstract Oncology

Results of KEYNOTE-240: phase 3 study of pembrolizumab (Pembro) vs best supportive care (BSC) for second line therapy in advanced hepatocellular carcinoma (HCC).

Richard S. Finn et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification

George N. Ioannou et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Biotechnology & Applied Microbiology

TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway

Tao Huang et al.

DISEASE MARKERS (2019)

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Review Gastroenterology & Hepatology

Insights into the success and failure of systemic therapy for hepatocellular carcinoma

Jordi Bruix et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Cell Biology

Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway

Hsiao-Chi Tsai et al.

AGING-US (2019)

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Article Nutrition & Dietetics

mir-101-3p Downregulation Promotes Fibrogenesis by Facilitating Hepatic Stellate Cell Transdifferentiation During Insulin Resistance

Marica Meroni et al.

NUTRIENTS (2019)

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Review Oncology

STAT3: An Emerging Therapeutic Target for Hepatocellular Carcinoma

Carol Lee et al.

CANCERS (2019)

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Article Cell Biology

Resistin facilitates VEGF-A-dependent angiogenesis by inhibiting miR-16-5p in human chondrosarcoma cells

Shiou-Sheng Chen et al.

CELL DEATH & DISEASE (2019)

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Review Oncology

Type 2 diabetes mellitus increases the risk of hepatocellular carcinoma in subjects with chronic hepatitis B virus infection: a meta-analysis and systematic review

Yifei Tan et al.

CANCER MANAGEMENT AND RESEARCH (2019)

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Article Medicine, General & Internal

TNF-alpha is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma

Wenliang Tan et al.

EBIOMEDICINE (2019)

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Review Radiology, Nuclear Medicine & Medical Imaging

2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the Management of Hepatocellular Carcinoma

Joong-Won Park et al.

KOREAN JOURNAL OF RADIOLOGY (2019)

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Article Gastroenterology & Hepatology

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Naga Chalasani et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

Chris Estes et al.

HEPATOLOGY (2018)

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Article Biochemistry & Molecular Biology

Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties

C-H Wang et al.

ONCOGENE (2018)

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Racial, Ethnic, and Age Disparities in Incidence and Survival of Intrahepatic Cholangiocarcinoma in the United States; 1995-2014

Samuel O. Antwi et al.

ANNALS OF HEPATOLOGY (2018)

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Article Pharmacology & Pharmacy

Resistin facilitates VEGF-C-associated lymphangiogenesis by inhibiting miR-186 in human chondrosarcoma cells

Chen-Ming Su et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Review Medicine, Research & Experimental

Diabetes and hepatocellular carcinoma: A pathophysiological link and pharmacological management

Mandeep Kumar Singh et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Risk factors for hepatocellular carcinoma by age, sex, and liver disorder status: A prospective cohort study in Korea

Sang-Wook Yi et al.

CANCER (2018)

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Resistin facilitates metastasis of lung adenocarcinoma through the TLR4/Src/EGFR/PI3K/NF-B pathway

Wei-Jing Gong et al.

CANCER SCIENCE (2018)

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Article Gastroenterology & Hepatology

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Jorge A. Marrero et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies

Tracey G. Simon et al.

HEPATOLOGY (2018)

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Impaired natural killer cell subset phenotypes in human obesity

Ina Baehr et al.

IMMUNOLOGIC RESEARCH (2018)

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EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Peter R. Galle et al.

JOURNAL OF HEPATOLOGY (2018)

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Metformin and risk of hepatocellular carcinoma in patients with type 2 diabetes

Chin-Hsiao Tseng

LIVER INTERNATIONAL (2018)

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Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

G. K. Abou-Alfa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Oncology

Insulin-like growth factor-1 induces epithelial-mesenchymal transition in hepatocellular carcinoma by activating survivin

Fangfeng Liu et al.

ONCOLOGY REPORTS (2018)

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Review Oncology

An insight on the association of glycation with hepatocellular carcinoma

Nasimudeen R. Jabir et al.

SEMINARS IN CANCER BIOLOGY (2018)

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Immunosuppression, Race, and Donor-Related Risk Factors Affect De novo Cancer Incidence Across Solid Organ Transplant Recipients

Mamatha Bhat et al.

MAYO CLINIC PROCEEDINGS (2018)

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Differences in hepatocellular carcinoma risk, predictors and trends over time according to etiology of cirrhosis

George N. Ioannou et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Novel oncogenic and chemoresistance-inducing functions of resistin in ovarian cancer cells require miRNAs-mediated induction of epithelial-to-mesenchymal transition

Ling Qiu et al.

SCIENTIFIC REPORTS (2018)

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Article Gastroenterology & Hepatology

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

Fasiha Kanwal et al.

GASTROENTEROLOGY (2018)

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The relationship between chemokines CCL2, CCL3, and CCL4 with the tumor microenvironment and tumor-associated macrophage markers in colorectal cancer

Marjorie De la Fuente López et al.

TUMOR BIOLOGY (2018)

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Review Gastroenterology & Hepatology

Evaluation of serum interleukin-6 levels in hepatocellular carcinoma patients: a systematic review and meta-analysis

Ebrahim Shakiba et al.

CLINICAL AND EXPERIMENTAL HEPATOLOGY (2018)

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Article Oncology

Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state

Parmanand Malvi et al.

CANCER & METABOLISM (2018)

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Review Oncology

Role of nonresolving inflammation in hepatocellular carcinoma development and progression

Le-Xing Yu et al.

NPJ PRECISION ONCOLOGY (2018)

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Meeting Abstract Oncology

A study of ramucirumab (LY3009806) versus placebo in patients with hepatocellular carcinoma and elevated baseline alpha-fetoprotein (REACH-2).

Andrew X. Zhu et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Oncology

Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale

Andrea Casadei Gardini et al.

EUROPEAN JOURNAL OF CANCER (2017)

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Article Biochemistry & Molecular Biology

Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3

Snahlata Singh et al.

FEBS LETTERS (2017)

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Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression

Jianan Pang et al.

HAEMATOLOGICA (2017)

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Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

Anthony B. El-Khoueiry et al.

LANCET (2017)

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Article Biochemistry & Molecular Biology

IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway

Ting-Ting Li et al.

MOLECULAR IMMUNOLOGY (2017)

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Review Oncology

Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies

Hedong Han et al.

ONCOTARGET (2017)

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Article Hematology

Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression

Jianan Pang et al.

HAEMATOLOGICA (2017)

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VEGF overexpression predicts poor survival in hepatocellular carcinoma

Sae Byeol Choi et al.

OPEN MEDICINE (2017)

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Pathophysiology of Diabetic Dyslipidaemia

Theodosios Filippatos et al.

CURRENT VASCULAR PHARMACOLOGY (2017)

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A national report from China Liver Transplant Registry: steroid avoidance after liver transplantation for hepatocellular carcinoma

Qiang Wei et al.

CHINESE JOURNAL OF CANCER RESEARCH (2017)

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Review Oncology

Type 2 diabetes mellitus and risk of hepatocellular carcinoma: spotlight on nonalcoholic fatty liver disease

Alessandro Mantovani et al.

ANNALS OF TRANSLATIONAL MEDICINE (2017)

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Independent of Cirrhosis, Hepatocellular Carcinoma Risk Is Increased with Diabetes and Metabolic Syndrome

Allison J. Kasmari et al.

AMERICAN JOURNAL OF MEDICINE (2017)

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Review Gastroenterology & Hepatology

The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development - a potential therapeutic target?

Paola Dongiovanni et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2016)

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Radiofrequency ablation-combined multimodel therapies for hepatocellular carcinoma: Current status

Lumin Chen et al.

CANCER LETTERS (2016)

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Hepatocellular carcinoma: From diagnosis to treatment

Miral Sadaria Grandhi et al.

SURGICAL ONCOLOGY-OXFORD (2016)

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Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation

Jung Ok Lee et al.

SCIENTIFIC REPORTS (2016)

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Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with new onset diabetes: a nationwide cohort study

S. -C. Fu et al.

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Resistin and Insulin Resistance: A Link Between Inflammation and Hepatocarcinogenesis

Engy Yousry Elsayed et al.

Asian Pacific Journal of Cancer Prevention (2015)

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Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma

Yuan Tian et al.

CANCER RESEARCH (2015)

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Resistin: Insulin resistance to malignancy

Pilar Codoner-Franch et al.

CLINICA CHIMICA ACTA (2015)

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Cost-effectiveness of sorafenib as a first-line treatment for advanced hepatocellular carcinoma

Pengfei Zhang et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2015)

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Review Gastroenterology & Hepatology

Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma

Hamza Chettouh et al.

LIVER INTERNATIONAL (2015)

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Down-regulated miR-28-5p in human hepatocellular carcinoma correlated with tumor proliferation and migration by targeting insulin-like growth factor-1 (IGF-1)

Xiaomin Shi et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)

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Decreased NK cell functions in obesity can be reactivated by fat mass reduction

Janine Jahn et al.

OBESITY (2015)

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Article Cell & Tissue Engineering

Resistin Promotes Angiogenesis in Endothelial Progenitor Cells Through Inhibition of MicroRNA206: Potential Implications for Rheumatoid Arthritis

Chen-Ming Su et al.

STEM CELLS (2015)

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Article Gastroenterology & Hepatology

Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk

Luca Miele et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2015)

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Review Endocrinology & Metabolism

Human resistin and the RELM of Inflammation in diabesity

Fatima Al Hannan et al.

DIABETOLOGY & METABOLIC SYNDROME (2015)

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Article Oncology

Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation

Sachin K. Deshmukh et al.

ONCOTARGET (2015)

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Article Oncology

Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells

Chun-Hao Tsai et al.

ONCOTARGET (2015)

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Article Gastroenterology & Hepatology

Opposite Association Between Diabetes, Dyslipidemia, and Hepatocellular Carcinoma Mortality in the Middle-Aged and Elderly

Chien-Hsieh Chiang et al.

HEPATOLOGY (2014)

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Article Biochemistry & Molecular Biology

Subendothelial resistin enhances' monocyte transmigration in a co-culture of human endothelial and smooth muscle cells by mechanisms involving fractalkine, MCP-1 and activation of TLR4 and Gi/o proteins signaling

Monica Madalina Pirvulescu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

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Article Gastroenterology & Hepatology

The Association Between Metabolic Syndrome and Hepatocellular Carcinoma Systemic Review and Meta-analysis

Raxitkumar Jinjuvadia et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2014)

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HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH

Samuele De Minicis et al.

PLOS ONE (2014)

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Review Endocrinology & Metabolism

Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review

Maisa Mahmoud Ali Kamkar et al.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2014)

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Article Oncology

Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study

W-P Koh et al.

BRITISH JOURNAL OF CANCER (2013)

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Article Genetics & Heredity

Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β

Rongjing Song et al.

GENE (2013)

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Review Oncology

Obesity, adipokines and hepatocellular carcinoma

Xiao-Feng Duan et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

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Article Biochemistry & Molecular Biology

Resistin Promotes the Expression of Vascular Endothelial Growth Factor in Ovary Carcinoma Cells

Li Pang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Article Gastroenterology & Hepatology

Hepatocellular carcinoma in patients with chronic kidney disease

Chern-Horng Lee et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Letter Medicine, General & Internal

Risk for Hepatocellular Carcinoma in Patients With Alcoholic Cirrhosis

Hans L. Tillman et al.

ANNALS OF INTERNAL MEDICINE (2012)

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Article Biochemistry & Molecular Biology

A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: Up-regulation of SOCS3 expression through STAT3 activation

Monica Pirvulescu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

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Metabolic syndrome and incidence of liver and breast cancers in Japan

Yoneatsu Osaki et al.

CANCER EPIDEMIOLOGY (2012)

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Review Endocrinology & Metabolism

Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis

Ping Wang et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2012)

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Article Biochemistry & Molecular Biology

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element

J. Xu et al.

ONCOGENE (2012)

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Article Urology & Nephrology

Expression of resistin in the prostate and its stimulatory effect on prostate cancer cell proliferation

Hae Jong Kim et al.

BJU INTERNATIONAL (2011)

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Review Cell Biology

NF-kappa B and STAT3 - key players in liver inflammation and cancer

Guobin He et al.

CELL RESEARCH (2011)

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Article Gastroenterology & Hepatology

Insulin Resistance and Other Metabolic Risk Factors in the Pathogenesis of Hepatocellular Carcinoma

Asma Siddique et al.

CLINICS IN LIVER DISEASE (2011)

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Article Cell Biology

Resistin Induces Monocyte-Endothelial Cell Adhesion by Increasing ICAM-1 and VCAM-1 Expression in Endothelial Cells via p38MAPK-Dependent Pathway

Wei-Yen Hsu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

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Review Oncology

Targeting insulin-like growth factor axis in hepatocellular carcinoma

Jennifer Wu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2011)

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Article Cardiac & Cardiovascular Systems

Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells

Changyi Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

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Review Gastroenterology & Hepatology

Radiofrequency Ablation of Hepatocellular Carcinoma: Pros and Cons

Hyunchul Rhim et al.

GUT AND LIVER (2010)

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Article Cell Biology

Resistin competes with lipopolysaccharide for binding to toll-like receptor 4

Andrej Tarkowski et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)

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Article Gastroenterology & Hepatology

Association of exogenous insulin or sulphonylurea treatment with an increased incidence of hepatoma in patients with hepatitis C virus infection

Takumi Kawaguchi et al.

LIVER INTERNATIONAL (2010)

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Article Gastroenterology & Hepatology

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease

Valter Donadon et al.

LIVER INTERNATIONAL (2010)

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Review Surgery

The Current Role of Radiofrequency Ablation in the Management of Hepatocellular Carcinoma A Systematic Review

Wan Yee Lau et al.

ANNALS OF SURGERY (2009)

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Article Hematology

EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2α-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2

Faten Bougatef et al.

BLOOD (2009)

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Article Pharmacology & Pharmacy

CHROMIUM PICOLINATE INHIBITS RESISTIN SECRETION IN INSULIN-RESISTANT 3T3-L1 ADIPOCYTES VIA ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE

Yi-Qun Wang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2009)

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Article Gastroenterology & Hepatology

Endocan Expression Correlated with Poor Survival in Human Hepatocellular Carcinoma

Geng-Wen Huang et al.

DIGESTIVE DISEASES AND SCIENCES (2009)

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Article Oncology

Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter -420C > G genotype

Dick Wagsater et al.

CANCER INVESTIGATION (2008)

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Article Gastroenterology & Hepatology

The prevalence of occult hepatitis B virus infection in type 2 diabetes mellitus patients

Mehmet Demir et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2008)

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Article Gastroenterology & Hepatology

Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: A follow-up study in Taiwan

Chi-Ling Chen et al.

GASTROENTEROLOGY (2008)

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Review Gastroenterology & Hepatology

Cellular and molecular mechanisms of liver injury

Harmeet Malhi et al.

GASTROENTEROLOGY (2008)

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Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Chemistry, Multidisciplinary

Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles

Hong-qi Fan et al.

ACTA PHARMACOLOGICA SINICA (2007)

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Article Pathology

Resistin as an intrahlepatic cytokine -: Overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells

Cristiana Bertolani et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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Article Nutrition & Dietetics

Proinflammatory cytokine production and insulin sensitivity regulated by overexpression of resistin in 3T3-L1 adipocytes

Yuchang Fu et al.

NUTRITION & METABOLISM (2006)

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Article Gastroenterology & Hepatology

Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases

E Yagmur et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)

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Article Endocrinology & Metabolism

Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes

Nicoletta Di Simone et al.

JOURNAL OF ENDOCRINOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Adipokine resistin promotes in vitro angiogenesis of human endothelial cells

H Mu et al.

CARDIOVASCULAR RESEARCH (2006)

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Article Biochemistry & Molecular Biology

Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling - A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells

YH Shen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Review Gastroenterology & Hepatology

Systematic review: evidence-based management of hepatocellular carcinoma - an updated analysis of randomized controlled trials

P. M. Lopez et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)

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Article Endocrinology & Metabolism

Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin

R Palanivel et al.

DIABETOLOGIA (2006)

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Article Biochemistry & Molecular Biology

Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway

N Silswal et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Gastroenterology & Hepatology

Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study

JA Davila et al.

GUT (2005)

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Article Gastroenterology & Hepatology

Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma

HB El-Serag et al.

GASTROENTEROLOGY (2004)

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Article Multidisciplinary Sciences

NF-κB functions as a tumour promoter in inflammation-associated cancer

E Pikarsky et al.

NATURE (2004)

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Article Urology & Nephrology

Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer

VE Theodoropoulos et al.

EUROPEAN UROLOGY (2004)

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Article Endocrinology & Metabolism

Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting

MW Rajala et al.

DIABETES (2004)

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Article Endocrinology & Metabolism

Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation

B Moon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)

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Review Biochemistry & Molecular Biology

Angiogenesis in health and disease

P Carmeliet

NATURE MEDICINE (2003)

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Article Immunology

Impaired primary immune response in type-1 diabetes: Results from a controlled vaccination study

N Eibl et al.

CLINICAL IMMUNOLOGY (2002)

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Article Biochemistry & Molecular Biology

A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation

KH Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Multidisciplinary Sciences

The hormone resistin links obesity to diabetes

CM Steppan et al.

NATURE (2001)

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Article Genetics & Heredity

Single nucleotide polymorphisms of the resistin (RSTN) gene

HN Cao et al.

JOURNAL OF HUMAN GENETICS (2001)

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