☆ 4.5 Review

DNA nanostructures as biomolecular scaffolds for antigen display

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2023)

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Summary: DNA nanotechnology is an interdisciplinary field that combines physics, chemistry, biology, mathematics, engineering, and materials science. The development of DNA origami technique by Paul Rothemund has greatly advanced the field and led to numerous innovative concepts, models, methodologies, and applications. This review highlights the recent progress in DNA origami-engineered nanomaterials over the past five years and explores the potential research directions. It is believed that the legacy of Nadrian Seeman will continue to inspire interdisciplinary innovations and practical applications in the next decade.

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A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response

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Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens

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Cryo-EM structure of the human IgM B cell receptor

Qiang Su et al.

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Self-Assembling Protein Nanoparticles in the Design of Vaccines: 2022 Update

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Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

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Summary: Protein nanoparticle scaffolds are widely used in vaccine design, but the relationship between immune responses specific to the scaffold and the immunogenicity of displayed antigens is still unclear. This study found that physical masking of anti-scaffold responses does not enhance antigen-specific antibody responses. When the scaffold is provided in excess, scaffold-specific antibody responses competitively inhibit antigen-specific responses.

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Stochastic modeling of antibody binding predicts programmable migration on antigen patterns

Ian T. Hoffecker et al.

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Tim K. Esser et al.

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SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Jing-Hui Tian et al.

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Emma Silvester et al.

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CELL (2021)

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Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys

Heng Li et al.

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Ting Cai et al.

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Protein-based antigen presentation platforms for nanoparticle vaccines

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A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response

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Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

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Protective Antibody and CD8+ T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine

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Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

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Labeling of fusion proteins with synthetic fluorophores in live cells

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