Neutrophils in COVID-19: recent insights and advances

Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant threat to human health. Studies have found that pathological mechanisms, such as cytokine storms caused by uncontrolled innate immune system activation, release of damage-associated molecular patterns during tissue injury and a high incidence of thrombotic events, are associated with the function and dysfunction of neutrophils. Specifically, the increased formation of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs) has been shown to be closely linked with the severity and poor prognosis in patients with COVID-19. Our work focuses on understanding the increased number, abnormal activation, lung tissue infiltration, and elevated neutrophil-to-lymphocyte ratio in the pathogenesis of COVID-19. We also explore the involvement of NETs and LDNs in disease progression and thrombosis formation, along with potential therapeutic strategies targeting neutrophil and NETs formation.

Automated summary

COVID-19 is a respiratory disease caused by SARS-CoV-2, leading to ARDS, organ failure, and death. Neutrophils play a critical role in the pathology, with increased formation of LDNs and NETs associated with disease severity and poor prognosis. Our research focuses on understanding the involvement of neutrophils, LDNs, and NETs in COVID-19 pathogenesis, as well as potential therapeutic strategies.