期刊
VETERINARY DERMATOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/vde.13195
关键词
alopecia X; dog; follicles; p63 immunoexpression; skin development; transcriptional factor defects
Through immunohistochemical staining of skin biopsies from Pomeranians affected by alopecia X, it was found that there was a significant decrease in the immunexpression of p63 in the hair follicles, indicating the involvement of p63 in the hair cycle.
Background: Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes. Hypothesis/Objectives: The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin. Animals: Skin biopsies from 19 alopecia X- affected and six control Pomeranians were analysed. Materials and Methods: Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples. Results: Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles. Conclusions and Clinical Relevance: The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.
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