☆ 4.5 Article

Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 spike ferritin nanoparticle vaccine antigen produced from two different cell lines

VACCINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Medicinal

Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real- time and Accelerated Stability Studies

Nitya Sharma et al.

Summary: This work outlines the development of a multi-dose formulation for a Human Papillomavirus (HPV) Virus-Like Particle (VLP) based vaccine. Storage stability studies identified eight lead candidates for the formulation, with optimal stability and antimicrobial effectiveness observed with certain preservatives.

JOURNAL OF PHARMACEUTICAL SCIENCES (2023)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

Prashant Kumar et al.

Summary: This review focuses on the importance of vaccine formulation containing Sabin strains for global polio eradication efforts. These formulations improve vaccine safety and lower costs, allowing for wider use in low- and middle-income countries. The article discusses formulation strategies, such as developing multidose and combination vaccine formats, to reduce costs and enhance immunogenicity.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2023)

添加到收藏夹

Article Multidisciplinary Sciences

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Payton A. -B. Weidenbacher et al.

Summary: While the development of COVID-19 vaccines has been successful, there is a need for a globally available vaccine that provides longer-lasting immunity against current and future variants of concern. One potential vaccine candidate is DCFHP, a protein-nanoparticle vaccine formulated with aluminum hydroxide as the adjuvant. It has shown promising results in eliciting potent and durable neutralizing antibodies in non-human primates against known variants and can be produced in large quantities. DCFHP has the potential to be used as a booster vaccine or as a primary vaccine for pediatric use.

NATURE COMMUNICATIONS (2023)

添加到收藏夹

Article Chemistry, Medicinal

Interaction of Aluminum-adjuvanted Recombinant P[4] Protein Antigen With Preservatives: Storage Stability and Backbone Flexibility Studies

Nishant Sawant et al.

Summary: This study examined the effects of eight antimicrobial preservatives on the stability of a non-replicating rotavirus vaccine antigen. The results showed a correlation between the hydrophobicity of the preservatives and the storage stability of the antigen. Hydrogen exchange-mass spectrometry was used to analyze the flexibility of the antigen's backbone. The findings provide insight into the development of multi-dose vaccine formulations for recombinant protein antigens.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

添加到收藏夹

Editorial Material Medicine, General & Internal

Addressing Vaccine Inequity - Covid-19 Vaccines as a Global Public Good

David J. Hunter et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Editorial Material Medicine, General & Internal

Closing the global vaccine equity gap: equitably distributed manufacturing

Victor J. Dzau et al.

LANCET (2022)

添加到收藏夹

Article Medicine, General & Internal

Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine

Karen J. Hager et al.

Summary: The CoVLP+AS03 vaccine showed efficacy in preventing Covid-19 caused by different variants, with efficacy ranging from 69.5% against symptomatic infection to 78.8% against moderate-to-severe disease.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques

Neil C. Dalvie et al.

Summary: Authorized vaccines against SARS-CoV-2 are not widely available in low- and middle-income countries due to supply shortages, high costs, and complex storage requirements. However, a new vaccine candidate using widely available, safe adjuvants has shown promising results in animal trials, eliciting protective immunity and demonstrating the potential benefits of a low-cost modular vaccine platform for SARS-CoV-2 and other variants.

SCIENCE ADVANCES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia

Ludek Berec et al.

Summary: Studies in Czech Republic show that the effectiveness of COVID-19 vaccines declines after 7-8 months, with a decrease in protection against infection, hospitalization, and death. Boosters are found to restore the original vaccine effectiveness, and post-infection immunity also diminishes over time.

PLOS ONE (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Sakshi Bajoria et al.

Summary: Low-cost, refrigerator-stable COVID-19 vaccines are important for global accessibility and vaccine coverage. This study found that aluminum-salt and CpG adjuvants decrease the stability of the RBD-J antigen, but enhance the immune response in mice, with the AH+CpG formulation being the most effective at inducing SARS-CoV-2 pseudovirus neutralizing antibodies.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

添加到收藏夹

Article Medicine, General & Internal

Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trial

Joon Young Song et al.

Summary: Vaccination has been crucial in controlling the COVID-19 pandemic, and GBP510, a recombinant protein vaccine, adjuvanted with AS03, has shown good safety and high immunogenicity against SARS-CoV-2. Reactogenicity was higher in the AS03 adjuvanted groups, with higher levels of anti-SARS-CoV-2-RBD IgG antibodies and neutralizing antibodies observed in participants who received the adjuvanted vaccine.

ECLINICALMEDICINE (2022)

添加到收藏夹

Article Chemistry, Medicinal

Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

Nishant Sawant et al.

Summary: A two-step developability assessment workflow was developed to identify stable, aluminum-adjuvanted, multi-dose vaccine candidates from variants of recombinant protein antigens. Promising P[8] variants were down-selected based on results from primary structure, post-translational modifications, antibody binding, conformational stability, solubility, and preservative compatibility assessments. Good correlations were observed between rapidly-generated developability screening data and storage stability profiles, especially for aluminum-adsorbed P[8] antigens.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Stabilizing the closed SARS-CoV-2 spike trimer

Jarek Juraszek et al.

Summary: Researchers have successfully created a stable variant of the SARS-CoV-2 S protein through structure-based design, with increased expression and correct folding predominantly in a closed prefusion conformation. This contributes to supporting vaccine development efforts.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

Abigail E. Powell et al.

Summary: By displaying SARS-CoV-2 spike proteins on ferritin nanoparticles, there was a notable enhancement in the elicitation of neutralizing antibodies, making it a viable strategy for single-dose vaccination against COVID-19.

ACS CENTRAL SCIENCE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Recombinant protein vaccines, a proven approach against coronavirus pandemics

Jeroen Pollet et al.

Summary: This article points out that recombinant protein vaccines may become a favorable option in the context of the COVID-19 pandemic, despite being overlooked in early development, they may offer an advantage or complement under the current circumstances.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2

Matan Levine-Tiefenbrun et al.

Summary: The study found that the effectiveness of the BNT162b2 vaccine in reducing viral loads of breakthrough infections decreases over time. However, this reduction in viral load can be restored by receiving a third vaccine dose.

NATURE MEDICINE (2021)

添加到收藏夹

Review Immunology

SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

Nikolaos C. Kyriakidis et al.

Summary: The new SARS-CoV-2 virus is rapidly spreading worldwide, causing the COVID-19 pandemic with more than 1.866 million deaths. Over 64 vaccine candidates are being developed globally, aiming to induce antibodies to prevent viral entry. Thirteen vaccine candidates are currently in Phase 3 clinical trials, showing promising progress towards approval for large-scale immunizations.

NPJ VACCINES (2021)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

M. Gordon Joyce et al.

Summary: The study designed and characterized four categories of engineered nanoparticle immunogens that induced robust antibodies against SARS-CoV-2, showing effectiveness against different variants and also significant neutralizing antibody titers against SARS-CoV-1. These immunogens demonstrated high protective efficacy in animal experiments, offering new insights for vaccine development and antiviral strategies.

CELL REPORTS (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

Joshua M. Carmen et al.

Summary: The study demonstrates that combining a nanoparticle vaccine with a potent adjuvant enhances SARS-CoV-2-specific durable adaptive immune T cell responses.

NPJ VACCINES (2021)

添加到收藏夹

Review Immunology

Scientific rationale for developing potent RBD-based vaccines targeting COVID-19

Harry Kleanthous et al.

Summary: Global vaccination against COVID-19 poses significant challenges in science, logistics, and ethics, with a need for safe, effective, high-volume, affordable vaccines; RBD-based vaccines may be a solution for filling the gap in global demand, offering high production potential and cost-effectiveness as a sole vaccine immunogen.

NPJ VACCINES (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Sharing Technology and Vaccine Doses to Address Global Vaccine Inequity and End the COVID-19 Pandemic

Matthew M. Kavanagh et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

Paul T. Heath et al.

Summary: The NVX-CoV2373 vaccine demonstrated an efficacy of 89.7% in a phase 3 trial with over 15,000 participants, with mild and transient reactogenicity. It showed high efficacy against the B.1.1.7 variant and a low incidence of adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021

Catherine M. Brown et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Article Chemistry, Medicinal

Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens

Sanjeev Agarwal et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

添加到收藏夹

Review Infectious Diseases

Aluminum and vaccines: Current state of knowledge

J-P Goulle et al.

MEDECINE ET MALADIES INFECTIEUSES (2020)

添加到收藏夹

Article Immunology

Adsorption onto aluminum hydroxide adjuvant protects antigens from degradation

Annalisa Colaprico et al.

VACCINE (2020)

添加到收藏夹

Article Immunology

Design of a broadly reactive Lyme disease vaccine

Heather D. Kamp et al.

NPJ VACCINES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Controlling the SARS-CoV-2 spike glycoprotein conformation

Rory Henderson et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

Ching-Lin Hsieh et al.

SCIENCE (2020)

添加到收藏夹

Article Chemistry, Medicinal

Analytical Comparability Assessments of 5 Recombinant CRM197 Proteins From Different Manufacturers and Expression Systems

John M. Hickey et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

添加到收藏夹

Review Immunology

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

Harm HogenEsch et al.

NPJ VACCINES (2018)

添加到收藏夹

Article Chemistry, Medicinal

Mechanisms of Antigen Adsorption Onto an Aluminum-Hydroxide Adjuvant Evaluated by High-Throughput Screening

Vanessa Jully et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

CHO Cells Can Make More Protein

Sarah W. Harcum et al.

CELL SYSTEMS (2016)

添加到收藏夹

Article Virology

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

Kwinten Sliepen et al.

RETROVIROLOGY (2015)

添加到收藏夹

Review Biochemical Research Methods

Analytical lessons learned from selected therapeutic protein drug comparability studies

Marcia Federici et al.

BIOLOGICALS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

Masaru Kanekiyo et al.

NATURE (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Key roles of adjuvants in modern vaccines

Steven G. Reed et al.

NATURE MEDICINE (2013)

添加到收藏夹

Review Immunology

Mechanism of immunopotentiation and safety of aluminum adjuvants

Harm HogenEsch

FRONTIERS IN IMMUNOLOGY (2013)

添加到收藏夹

Article Chemistry, Medicinal

Vaccines with Aluminum-containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability

Tanya Clapp et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

添加到收藏夹

Review Immunology

Vaccine Adjuvants: Putting Innate Immunity to Work

Robert L. Coffman et al.

IMMUNITY (2010)

添加到收藏夹

Article Immunology

Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response

Stephanie M. Noe et al.

VACCINE (2010)

添加到收藏夹

Article Immunology

Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response

Bethany Hansen et al.

VACCINE (2009)

添加到收藏夹

Article Immunology

Relationship between tightness of binding and immunogenicity in an aluminum-containing adjuvant-adsorbed hepatitis B vaccine

Patricia M. Egan et al.

VACCINE (2009)

添加到收藏夹

Article Chemistry, Medicinal

Effects of stabilizers on the destabilization of proteins upon adsorption to aluminum salt adjuvants

Laura J. Peek et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

添加到收藏夹

Article Immunology

Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants

Ilia Z. Romero Mendez et al.

VACCINE (2007)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Association between immunogenicity and adsorption of a recombinant Streptococcus pneumoniae vaccine antigen by an aluminum adjuvant

Philip M. Levesque et al.

HUMAN VACCINES (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens

LS Jones et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

添加到收藏夹

Article Cell Biology

Aluminium compounds for use in vaccines

EB Lindblad

IMMUNOLOGY AND CELL BIOLOGY (2004)

添加到收藏夹

Article Immunology

Relationship between the degree of antigen adsorption to aluminum hydroxide adjuvant in interstitial fluid and antibody production

S Iyer et al.

VACCINE (2003)

添加到收藏夹

Article Immunology

Degree of antigen adsorption in the vaccine or interstitial fluid and its effect on the antibody response in rabbits

MF Chang et al.

VACCINE (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.