期刊
VACCINE
卷 41, 期 39, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2023.08.008
关键词
Pertussis; Tetanus-diphtheria-acellular pertussis vaccine; Healthcare professionals vaccination
The study reveals that a significant number of healthcare professionals in Brazil are not immune to pertussis. It also highlights the low awareness and coverage of Tdap vaccination among these professionals. The research further demonstrates that Tdap vaccination can increase anti-pertussis toxin antibody levels, which gradually decline over time.
Introduction: Worldwide, tetanus-diphtheria-acellular pertussis (Tdap) vaccination coverage of healthcare professionals (HCPs) is below 40%, but this data is not available for Brazil. We hypothesize that a high number of HCPs are not immune to pertussis in Brazil. Main objective was to determine the seroprevalence of anti-pertussis toxin (anti-PT IgG) among HCPs. Secondary objectives were to evaluate Tdap vaccination coverage, to assess predictive factors associated with anti-PT IgG, and to estimate the decay of anti-PT IgG and time to Tdap vaccination. Methods: Observational cross-sectional serological study in 352 HCPs who worked at Sao Paulo Hospital - Federal University of Sao Paulo (UNIFESP) in 2020, approved by UNIFESP Ethics Committee. Data collected included sociodemographics, knowledge about Tdap, and vaccination status. Anti-PT IgG were quantified by ELISA: < 10 IU/mL seronegative and >= 10-1000 IU/mL seropositive. Titers >= 10-50 IU/mL were classified low positivity, indicating no recent B. pertussis infection or Tdap vaccination; > 50 IU/mL high positivity, indicating recent B. pertussis infection or Tdap vaccination, and > 100 IU/mL as acute B. pertussis infection or Tdap vaccination in the previous year. Comparisons were done by Chi-square test, multivariable logistic regression, and Pearsons correlation, at 5% p-level. Results: 331/352 HCPs were not aware the Brazilian National Immunization Program recommends Tdap for all HCPs and pregnant women. 68/339 HCPs received Tdap (mean 3.1 +/- 2.0 years). 55/352 were seronegative for pertussis, all unvaccinated. 56/271 with no history of Tdap vaccination had high positivity. The probability of anti-PT IgG > 50 IU/mL was 11.5 times higher in Tdap vaccinated HCPs than in non-vaccinated (p < 0.001). There was a weak but significant correlation between anti-PT IgG and interval of Tdap vaccination (r = 0.404; p = 0.001). Anti-PT IgG dropped 5 IU/mL/year (p = 0.001). Conclusion: Better education of HCPs on needs and benefits of Tdap vaccination is critical. Goals must be to improve HCPs vaccination coverage.
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