期刊
MULTIMEDIA TOOLS AND APPLICATIONS
卷 76, 期 19, 页码 19491-19505出版社
SPRINGER
DOI: 10.1007/s11042-015-3191-3
关键词
1H-MRS technology; LC Model software; Quantitative analysis; Metabolite concentrations
类别
资金
- Humanities and Social Sciences Research Fund of Ministry of Education of the People's Republic of China (MOE of PRC) [13YJC890032]
- General Project of Xinjiang Ethnic Sports Culture Research Center [XJEDU040613C03]
- key discipline of Xinjiang Uighur Autonomous Region, Sports Humanistic Sociology
Hydrogen proton magnetic resonance spectroscopy (1H-MRS) was widely used in the auxiliary diagnosis of clinical diseases. However, in the previous study on hippocampal metabolites, the relative ratio of magnetic resonance spectroscopic data common area blow the crest or crest height was used for semi-quantitative or relative quantitative analysis. Although it was convenient to observe the change trend for this method, it could not accurately reflect the specific changes of various metabolites concentrations. So it had a certain limitation. Based on Linear Combination of Model Spectra (LCmodel) processing technology this paper introduced the spectroscopic imaging technology into the analysis procedures. The absolute concentration of brain metabolites was quantitatively detected in the hippocampus of adolescent obese metabolic syndrome. The results showed that the levels of NAA, Cho and MI in bilateral hippocampuses of adolescent metabolic syndrome were significantly decreased, especially in right hippocampus. The application of LCmodel software brought great convenience to realize the absolute quantification of metabolites in vivo.
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