4.0 Article

Outcomes in patients with BRAFV600-mutated melanoma and brain metastases at baseline treated with dabrafenib plus trametinib

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Real-world data on melanoma brain metastases and survival outcome

Sidsel Pedersen et al.

Summary: Novel medical therapies have significantly improved the outcome for melanoma patients, including those with brain metastases. Surgical excision is the most effective treatment option, while whole-brain radiation therapy results in the worst outcome. Immunotherapy plays a crucial role in the long-term survival of patients diagnosed with melanoma brain metastases.

MELANOMA RESEARCH (2022)

Article Oncology

The Analysis of Trends in Survival for Patients with Melanoma Brain Metastases with Introduction of Novel Therapeutic Options before the Era of Combined Immunotherapy-Multicenter Italian-Polish Report

Joanna Placzke et al.

Summary: The landscape of treatment for patients with melanoma brain metastases is constantly evolving, with the introduction of modern treatment options leading to improved prognosis for patients across different prognostic groups.

CANCERS (2022)

Review Oncology

Retrospective Chart Review of Dabrafenib Plus Trametinib in Patients with Metastatic BRAF V600-Mutant Melanoma Treated in the Individual Patient Program (DESCRIBE Italy)

Massimo Aglietta et al.

Summary: The study investigated the use of dabrafenib plus trametinib in real-world setting for patients with BRAF V600-mutant metastatic melanoma, showing effective and safe outcomes, especially for patients with higher tumor burden. Treatment discontinuation due to adverse events was low, and there were no new safety concerns observed.

TARGETED ONCOLOGY (2021)

Article Oncology

Outcome of melanoma patients with elevated LDH treated with first-line targeted therapy or PD-1-based immune checkpoint inhibition

Sarah Knispel et al.

Summary: Elevated LDH is a negative prognostic factor for patients with metastatic melanoma. In BRAF-mutant patients, combination immunotherapy may be more beneficial than targeted therapy, while in patients receiving ICI as first-line treatment, a combination of anti-PD-1 and anti-CTLA-4 could lead to longer OS compared to anti-PD-1 monotherapy.

EUROPEAN JOURNAL OF CANCER (2021)

Article Oncology

A Retrospective Analysis of Dabrafenib and/or Dabrafenib Plus Trametinib Combination in Patients with Metastatic Melanoma to Characterize Patients with Long-Term Benefit in the Individual Patient Program (DESCRIBE III)

Victoria G. Atkinson et al.

Summary: Compassionate-use programs allow for retrospective evaluation of treatment patterns and clinical outcomes in real-world settings to validate results from controlled trials. DESCRIBE III study identified lower LDH levels and fewer metastatic sites as baseline characteristics associated with long-term benefit in patients treated with dabrafenib + trametinib.

CANCERS (2021)

Article Oncology

Real-World Experience with Targeted Therapy in BRAF Mutant Advanced Melanoma Patients: Results from a Multicenter Retrospective Observational Study Advanced Melanoma in Russia (Experience) (ADMIRE)

Kristina V. Orlova et al.

Summary: Real-world data on treatment patterns and clinical outcomes for advanced BRAF V600 mutant melanoma patients are limited, but the study shows the effectiveness and good safety profile of combined TT with BRAF plus MEK inhibitors across all lines of therapy, including patients with brain metastases.

CANCERS (2021)

Review Oncology

Lactate dehydrogenase: a marker of diminished antitumor immunity

Sandra Van Wilpe et al.

ONCOIMMUNOLOGY (2020)

Article Oncology

Gender Differences and Outcomes in Melanoma Patients

Francesca Morgese et al.

ONCOLOGY AND THERAPY (2020)

Article Medicine, General & Internal

Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma

C. Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Biochemistry & Molecular Biology

Genomic Classification of Cutaneous Melanoma

Rehan Akbani et al.

Article Medicine, General & Internal

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Environmental Sciences

Melanoma in the Italian Population and Regional Environmental Influences: A National Retrospective Survey on 2001-2008 Hospitalization Records

Prisco Piscitelli et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2015)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma

G. V. Long et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Dermatology

Melanoma incidence and mortality in Europe: new estimates, persistent disparities

A. M. Forsea et al.

BRITISH JOURNAL OF DERMATOLOGY (2012)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)