Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial

Article Gastroenterology & Hepatology

The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study

Eikichi Ihara et al.

Summary: This study demonstrated that acotiamide effectively reduced the integrated relaxation pressure (IRP) of the lower esophageal sphincter (LES) and decreased LES accommodation index in patients with EGJOO. Acotiamide normalized IRP levels in some patients and significantly improved dysphagia symptoms in a subset of patients. Dysphagia is an important symptom to be considered and treated in patients with EGJOO.

ESOPHAGUS (2022)

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Article Gastroenterology & Hepatology

Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(C)

Rena Yadlapati et al.

Summary: CCv4.0 is an updated classification scheme for esophageal motility disorders using HRM, developed by fifty-two international experts in seven subgroups over two years. Key updates include a more rigorous and expansive HRM protocol, refined definition of EGJOO, stricter criteria for ineffective esophageal motility, and description of baseline EGJ metrics. These changes aim to provide more standardized criteria for disorders of peristalsis and obstruction at the EGJ.

NEUROGASTROENTEROLOGY AND MOTILITY (2021)

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Article Multidisciplinary Sciences

Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows

Kazumasa Muta et al.

Summary: This study utilized high-resolution manometry to observe dry and wet swallows in normal individuals and patients with idiopathic EGJOO, finding that LES accommodation occurs during wet swallows but is impaired in patients with idiopathic EGJOO. The measurement of LES accommodation may be useful in evaluating LES relaxation function in clinical practice.

SCIENTIFIC REPORTS (2021)

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Article Gastroenterology & Hepatology

Effects of Acotiamide on the Esophageal Motility Function in Patients with Esophageal Motility Disorders: A Pilot Study

Kazumasa Muta et al.

DIGESTION (2016)

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Article Gastroenterology & Hepatology

The Chicago Classification of esophageal motility disorders, v3.0

P. J. Kahrilas et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2015)

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Review Gastroenterology & Hepatology

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Peter J. Kahrilas et al.

GASTROENTEROLOGY (2013)

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Article Gastroenterology & Hepatology

A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia

Kei Matsueda et al.

GUT (2012)

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Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial

相关参考文献

The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study

Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(C)

Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows

Effects of Acotiamide on the Esophageal Motility Function in Patients with Esophageal Motility Disorders: A Pilot Study

The Chicago Classification of esophageal motility disorders, v3.0

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia

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