The therapeutic potential of natural killer cells in neuropathic pain

Novel disease-modifying treatments for neuropathic pain are urgently required. The cellular immune response to nerve injury represents a promising target for therapeutic development. Recently, the role of natural killer (NK) cells in both CNS and PNS disease has been the subject of growing interest. In this opinion article, we set out the case for NK cell-based intervention as a promising avenue for development in the management of neuropathic pain. We explore the poten-tial cellular and molecular targets of NK cells in the PNS by contrasting with their reported functional roles in CNS diseases, and we suggest strategies for using the beneficial functions of NK cells and immune-based therapeutics in the con-text of neuropathic pain.

Automated summary

Novel disease-modifying treatments for neuropathic pain are urgently needed. The role of natural killer (NK) cells in both central nervous system (CNS) and peripheral nervous system (PNS) diseases is of growing interest. This opinion article explores the potential targets of NK cells in the PNS and suggests strategies for utilizing the beneficial functions of NK cells and immune-based therapeutics in the management of neuropathic pain.