Cold blooded vertebrates help unveil a heat-dependent trigger

Article Multidisciplinary Sciences

Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1

Shogo Hori et al.

Summary: The authors discovered that the heat activation threshold of TRPV1 in tailed amphibians is reduced by substitution of two specific amino acids in the N-terminal region, suggesting their role in cool-habitat selection.

NATURE COMMUNICATIONS (2023)

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Review Biochemistry & Molecular Biology

Thermodynamic and structural basis of temperature-dependent gating in TRP channels

Ignacio Diaz-Franulic et al.

Summary: Living organisms rely on detecting environmental thermal cues for survival, with mammals having a complex system of Transient Receptor Potential ion channels that are controlled by various factors. The thermoTRP channels subgroup exhibits unique temperature dependence, and understanding the temperature-driven gating mechanisms remains a challenge.

BIOCHEMICAL SOCIETY TRANSACTIONS (2021)

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Article Neurosciences

Identification of a helix-turn-helix motif for high temperature dependence of vanilloid receptor TRPV2

Beiying Liu et al.

Summary: The study unveils the molecular basis underlying the high temperature dependence of the heat-sensitive TRPV2 channel, revealing a key molecular region in the proximal N-terminus that dictates the heat activation profile of the channel.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Article Biochemistry & Molecular Biology

Heat-dependent opening of TRPV1 in the presence of capsaicin

Do Hoon Kwon et al.

Summary: The cryo-EM structures of rat TRPV1 at different temperatures reveal the heat-dependent gating mechanism of this sensory receptor. By visualizing the opening of TRPV1 in response to noxious heat in the presence of capsaicin, the study shows that the conformational transitions leading to TRPV1 opening occur stepwise. The research also suggests that a subset of residues forms an interaction network directly involved in heat sensing, providing insights into the molecular principles underlying sensing of physical and chemical stimuli by TRPV1, which may be applicable to other thermal sensing ion channels.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Article Biophysics